NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli

Biochemical and Biophysical Research Communications

Volumn 408, Issue 2, 2011, Pages 242-247

  Ilatovskaya, Daria V ^a,b   Levchenko, Vladislav ^a   Ryan, Robert P ^a   Cowley, Allen W ^a   Staruschenko, Alexander ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

Focal segmental glomerulosclerosis; FSGS; Podocyte; TRPC6

Indexed keywords

CALCIUM; DICLOFENAC; IBUPROFEN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; ELECTRON MICROSCOPY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS FILTRATION; MALE; NONHUMAN; PATCH CLAMP; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; IBUPROFEN; KIDNEY GLOMERULUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRPC CATION CHANNELS;

RATTUS;

EID: 79955662243     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.005     Document Type: Article

References (19)

1. Machuca E., Benoit G., Antignac C. Genetics of nephrotic syndrome: connecting molecular genetics to podocyte physiology. Hum. Mol. Genet. 2009, 18:R185-R194.
2. Reiser J., Polu K.R., Moller C.C., Kenlan P., Altintas M.M., Wei C., Faul C., Herbert S., Villegas I., Vila-Casado C., McGee M., Sugimoto H., Brown D., Kalluri R., Mundel P., Smith P.L., Clapham D.E., Pollak M.R. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 2005, 37:739-744.
3. Winn M.P., Conlon P.J., Lynn K.L., Farrington M.K., Creazzo T., Hawkins A.F., Daskalakis N., Kwan S.Y., Ebersviller S., Burchette J.L., Pericak-Vance M.A., Howell D.N., Vance J.M., Rosenberg P.B. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005, 308:1801-1804.
4. Choi S.H., Aid S., Bosetti F. The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. Trends Pharmacol. Sci. 2009, 30:174-181.
5. McCarthy E.T., Sharma M. Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum. Kidney Int. 2002, 61:534-541.
6. Pavenstadt H., Bek M. Podocyte electrophysiology, in vivo and in vitro. Microsc. Res. Tech. 2002, 57:224-227.
7. Gloy J., Henger A., Fischer K.G., Nitschke R., Mundel P., Bleich M., Schollmeyer P., Greger R., Pavenstadt H. Angiotensin II depolarizes podocytes in the intact glomerulus of the Rat. J. Clin. Invest. 1997, 99:2772-2781.
8. Dahly-Vernon A.J., Sharma M., McCarthy E.T., Savin V.J., Ledbetter S.R., Roman R.J. Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. Hypertension 2005, 45:643-648.
9. Sharma R., Khanna A., Sharma M., Savin V.J. Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals. Kidney Int. 2000, 58:131-136.
10. Savin V.J., Sharma R., Lovell H.B., Welling D.J. Measurement of albumin reflection coefficient with isolated rat glomeruli. J. Am. Soc. Nephrol. 1992, 3:1260-1269.
11. Holthofer H., Virtanen I. Glycosylation of developing human glomeruli: lectin binding sites during cell induction and maturation. J. Histochem. Cytochem. 1987, 35:33-37.
12. Dietrich A., Schnitzler M., Emmel J., Kalwa H., Hofmann T., Gudermann T. N-Linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J. Biol. Chem. 2003, 278:47842-47852.
13. Dryer S.E., Reiser J. TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am. J. Physiol. Renal Physiol. 2010, 299:F689-F701.
14. Colquhoun D., Sigworth F.J. Fitting and statistical analysis of single-channel records. Single-Channel Recording 1995, 483-587. Plenum, New York. B. Sakmann, E. Neher (Eds.).
15. Huber T.B., Gloy J., Henger A., Schollmeyer P., Greger R., Mundel P., Pavenstadt H. Catecholamines modulate podocyte function. J. Am. Soc. Nephrol. 1998, 9:335-345.
16. Heeringa S.F., Moller C.C., Du J., Yue L., Hinkes B., Chernin G., Vlangos C.N., Hoyer P.F., Reiser J., Hildebrandt F. A novel TRPC6 mutation that causes childhood FSGS. PLoS One 2009, 4:e7771.
17. Moller C.C., Wei C., Altintas M.M., Li J., Greka A., Ohse T., Pippin J.W., Rastaldi M.P., Wawersik S., Schiavi S., Henger A., Kretzler M., Shankland S.J., Reiser J. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J. Am. Soc. Nephrol. 2007, 18:29-36.
18. Dinchuk J.E., Car B.D., Focht R.J., Johnston J.J., Jaffee B.D., Covington M.B., Contel N.R., Eng V.M., Collins R.J., Czerniak P.M. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995, 378:406-409.
19. Cheng H., Fan X., Guan Y., Moeckel G.W., Zent R., Harris R.C. Distinct roles for basal and induced COX-2 in podocyte injury. J. Am. Soc. Nephrol. 2009, 20:1953-1962.