Ciprofloxacin-induced theophylline toxicity: A population-based study

European Journal of Clinical Pharmacology

Volumn 67, Issue 5, 2011, Pages 521-526

  Antoniou, Tony ^a,b,f   Gomes, Tara ^a,c   Mamdani, Muhammad M ^a,b,c,d   Juurlink, David N ^a,c,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e Institute of Clinical Evaluative Sciences   (Canada)

^f King Saud University ^*  (Canada)

Author keywords

Ciprofloxacin; Ciprofloxacin adverse effects; Drug interactions; Theophylline poisoning

Indexed keywords

CIPROFLOXACIN; THEOPHYLLINE;

AGED; ARTICLE; CANADA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; GERIATRIC ASSESSMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT IDENTIFICATION; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; UNSPECIFIED SIDE EFFECT;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CIPROFLOXACIN; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; ONTARIO; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; THEOPHYLLINE;

EID: 79955641946     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0985-0     Document Type: Article

References (40)

1. Barnes PJ (2005) Theophylline in chronic obstructive pulmonary disease: new horizons. Proc Am Thorac Soc 2:334-339
2. Zhou Y, Wang X, Zeng X et al (2006) Positive benefits of theophylline in a randomized, double-blind, parallel-group, placebo-controlled study of low-dose, slow-release theophylline in the treatment of COPD for 1 year. Respirology 11:603-610 (Pubitemid 44186267)
3. Ram FS, Jardin JR, Atallah A et al (2005) Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Med 99:135-144 (Pubitemid 40104268)
4. Yasui K, Agematsu K, Shinozaki K et al (2000) Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism. J Leukoc Biol 67:529-535
5. Ito K, Lim S, Caramori G et al (2002) A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 99:8921-8926 (Pubitemid 34693659)
6. Barnes PJ, Adcock IM, Ito K (2005) Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 25:552-563 (Pubitemid 40331188)
7. Ford PA, Durham AL, Russell RE, Gordon F, Adcock IM, Barnes PJ (2010) Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest 137:1338-1344
8. Cosio BG, Soriano JB (2009) Theophylline again? Reasons for believing. Eur Respir J 34:5-6
9. Wang Y, Wang CZ, Lin KX, Qian GS, Zhuo WL, Li SP (2005) Comparison of inhaled corticosteroid combined with theophylline and double-dose inhaled corticosteroid in moderate to severe asthma. Respirology 10:189-195 (Pubitemid 40638003)
10. Dadashzadeh S, Tajerzaden H (2001) Dose dependent pharmacokinetics of theophylline: Michaelis-Menten parameters for its major metabolic pathways. Eur J Drug Metab Pharmacokinet 26:77-83 (Pubitemid 32802399)
11. Dahlqvist R, Billing B, Miners JO, Birkett DJ (1984) Nonlinear metabolic disposition of theophylline. Ther Drug Monit 6:290-297 (Pubitemid 14037119)
12. Self TH, Chafin CC, Soberman JE (2000) Effect of disease states on theophylline serum concentrations: are we still vigilant? Am J Med Sci 319:177-182 (Pubitemid 30395202)
13. Sessler CN (1990) Theophylline toxicity: clinical features of 116 consecutive cases. Am J Med 88:567-576
14. Mountain RD, Neff TA (1984) Oral theophylline intoxication. a serious error of patient and physician understanding. Arch Intern Med 144:724-727 (Pubitemid 14173514)
15. Pashko S, Simons WR, Sena MM, Stoddard ML (1994) Rate of exposure to theophylline-drug interactions. Clin Ther 16:1068-1077
16. Zhang ZY, Kaminsky LS (1995) Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochem Pharmacol 50:205-211
17. Ha HR, Chen J, Freiburghaus AU, Follath F (1995) Metabolism of theophylline by cDNA-expressed human cytochromes P-450. Br J Clin Pharmacol 39:321-326
18. Mahr G, Sörgel F, Granneman GR et al (1992) Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine. Clin Pharmacokinet 22[Suppl 1]:90-97
19. Fuhr U, Anders EM, Mahr G, Sörgel F, Staib AH (1992) Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother 36:942-948
20. Iyer Parameswaran G, Murphy TF (2009) Chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient. Drugs Aging 26 (12):985-995
21. Albertson TE, Chan AL (2009) Antibiotic therapy in elderly patients with acute exacerbation of chronic bronchitis. Expert Rev Respir Med 3:539-548
22. Batty KT, Davis TM, Ilett KF, Dusci LJ, Langton SR (1995) The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects. Br J Clin Pharmacol 39:305-311
23. Davis RL, Quenzer RW, Kelly HW, Powell JR (1992) Effect of the addition of ciprofloxacin on theophylline pharmacokinetics in subjects inhibited by cimetidine. Ann Pharmacother 26:11-13
24. Schwartz J, Jauregui L, Lettieri J, Bachmann K (1988) Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serum. Antimicrob Agents Chemother 32:75-77 (Pubitemid 18025680)
25. Loi CM, Parker BM, Cusack BJ, Vestal R (1993) Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers. Br J Clin Pharmacol 36:195-200 (Pubitemid 23275334)
26. Robson RA, Begg EJ, Atkinson HC, Saunders DA, Frampton CM (1990) Comparative effects of ciprofloxacin and lomefloxacin on the oxidative metabolism of theophylline. Br J Clin Pharmacol 29:491-493
27. Prince RA, Casabar E, Adair CG, Wexler DB, Lettieri J, Kasik JE (1989) Effect of quinolone antimicrobials on theophylline pharmacokinetics. J Clin Pharmacol 29:650-654 (Pubitemid 19199825)
28. Wijnands WJ, Vree TB, van Herwaarden CL (1986) The influence of quinolone derivatives on theophylline clearance. Br J Clin Pharmacol 22:677-683 (Pubitemid 17199007)
29. Spivey JM, Laughlin PH, Goss TF, Nix DE (1991) Theophylline toxicity secondary to ciprofloxacin administration. Ann Emerg Med 20:1131-1134
30. Semel JD, Allen N (1991) Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. South Med J 84:465-468
31. Karki SD, Bentley DW, Raghavan M (1990) Seizure with ciprofloxacin and theophylline combined therapy. DICP 24:595-596 (Pubitemid 20189005)
32. Richardson JP (1990) Theophylline toxicity associated with the administration of ciprofloxacin in a nursing home patient. J Am Geriatr Soc 38:236-238
33. Thomson AH, Thomson GD, Hepburn M, Whiting B (1987) A clinically significant interaction between ciprofloxacin and theophylline. Eur J Clin Pharmacol 33:435-436 (Pubitemid 17164972)
34. Juurlink DN, Mamdani M, Kopp A, Laupacis A, Redelmeier DA (2003) Drug-drug interactions among elderly patients hospitalized for drug toxicity. JAMA 289:1652-1658 (Pubitemid 37430270)
35. Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, Redelmeier DA (2004) Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 351:543-551 (Pubitemid 39025171)
36. Park-Wyllie LY, Juurlink DN, Kopp A et al (2006) Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med 354:1352-1361
37. Lipscombe LL, Gomes T, Lévesque LE, Hux JE, Juurlink DN, Alter DA (2007) Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA 298:2634-2643 (Pubitemid 350254955)
38. Lubin JH, Gail MH (1984) Biased selection of controls for casecontrol analyses of cohort studies. Biometrics 40:63-75
39. Austin PC, Grootendorst P, Anderson GM (2007) A comparison of the ability of different propensity score models to balance measured variables between treated and untreated subjects: a Monte Carlo study. Stat Med 26:734-753 (Pubitemid 46206593)
40. Schneeweiss S, Seeger JD, Maclure M, Wang PS, Avorn J, Glynn RJ (2001) Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. Am J Epidemiol 154:854-864 (Pubitemid 33000813)