Preparation of bleomycin A2-PLGA microspheres and related in vitro and in vivo studies

Journal of Pharmaceutical Sciences

Volumn 100, Issue 7, 2011, Pages 2790-2800

  Zhang, Haifeng ^a   Gao, Yang ^a   Lv, Wei ^a   Jiao, Chengfeng ^a   Duan, Minghua ^b   Liu, Huaiyu ^a   Han, Bing ^a  

^a JILIN UNIVERSITY   (China)

^b CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Controlled release; Microsphere; Pharmacodynamics; Polymers; Toxicology

Indexed keywords

BLEOMYCIN A2; MICROSPHERE; POLYGLACTIN; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG FORMULATION; DRUG SYNTHESIS; EVAPORATION; FEMALE; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; LUNG INJURY; LUNG TOXICITY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; RAT; SQUAMOUS CELL CARCINOMA; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DELAYED RELEASE FORMULATION; INTRAMUSCULAR DRUG ADMINISTRATION; LUNG FIBROSIS; METHODOLOGY; PHARMACEUTICS; SOLUBILITY; SYNTHESIS; SYRIAN HAMSTER; WISTAR RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; CRICETINAE; DELAYED-ACTION PREPARATIONS; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; INJECTIONS, INTRAMUSCULAR; LACTIC ACID; MALE; MASS SPECTROMETRY; MESOCRICETUS; MICE; MICROSPHERES; POLYGLYCOLIC ACID; PULMONARY FIBROSIS; RATS; RATS, WISTAR; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 79955636910     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22514     Document Type: Article

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