메뉴 건너뛰기




Volumn 4, Issue 1, 2011, Pages 15-21

Molecularly targeted therapy for metastatic colon cancer: Proven treatments and promising new agents

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; DASATINIB; ENZASTAURIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; EVEROLIMUS; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; ISPINESIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MONOCLONAL ANTIBODY; MOTESANIB; OXALIPLATIN; PANITUMUMAB; SARACATINIB; SUNITINIB; TEMSIROLIMUS; VANDETANIB; VATALANIB;

EID: 79955636598     PISSN: 19347820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (67)

References (46)
  • 1
    • 77955978565 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta, Ga: American Cancer Society
    • American Cancer Society: Cancer Facts and Figures 2010. Atlanta, Ga: American Cancer Society, 2010.
    • (2010) Cancer Facts and Figures 2010
  • 2
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343:905-914, 2000
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1
  • 3
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg, RM: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22:23-30, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1
  • 4
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A: Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 26:5326-5334, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 5326-5334
    • Grothey, A.1
  • 5
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS: Tumor angiogenesis. N Engl J Med 358:2039-49, 2008
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 6
    • 33845439397 scopus 로고    scopus 로고
    • The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma
    • Tassi E, Wellstein A: The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma. Semin Oncol 33:S50-S56, 2006
    • (2006) Semin Oncol , vol.33
    • Tassi, E.1    Wellstein, A.2
  • 7
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011-1027, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 8
    • 0033941120 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer
    • Cascinu S, Staccioli MP, Gasparini G, et al: Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. Clin Cancer Res 6:2803-2807, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 2803-2807
    • Cascinu, S.1    Staccioli, M.P.2    Gasparini, G.3
  • 9
    • 0034075041 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
    • Lee JC, Chow NH, Wang ST, et al: Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 36:748-753, 2000
    • (2000) Eur J Cancer , vol.36 , pp. 748-753
    • Lee, J.C.1    Chow, N.H.2    Wang, S.T.3
  • 10
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186, 1971
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 11
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 19:843-850, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 12
    • 33750373924 scopus 로고    scopus 로고
    • Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer
    • Ellis LM: Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer. Semin Oncol 33:S1-S7, 2006
    • (2006) Semin Oncol , vol.33
    • Ellis, L.M.1
  • 13
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 14
    • 34547494400 scopus 로고    scopus 로고
    • Complication rates following hepatic surgery in patients receiving neoadjuvant bevacizumab (BV) for colorectal cancer (CRC) liver metastases
    • (abstr 234)
    • Kesmodel SB, Ellis LM, Lin E, et al: Complication rates following hepatic surgery in patients receiving neoadjuvant bevacizumab (BV) for colorectal cancer (CRC) liver metastases. 2007 Gastrointestinal Cancers Symposium, 2007 (abstr 234)
    • (2007) 2007 Gastrointestinal Cancers Symposium
    • Kesmodel, S.B.1    Ellis, L.M.2    Lin, E.3
  • 15
    • 42949130734 scopus 로고    scopus 로고
    • Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer
    • Gruenberger B, Tamandl D, Schueller J, et al: Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer. J Clin Oncol 26:1830-1835, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1830-1835
    • Gruenberger, B.1    Tamandl, D.2    Schueller, J.3
  • 16
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al: Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26:2013-2019, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 17
    • 69549147378 scopus 로고    scopus 로고
    • A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08
    • (abstr LBA4)
    • Wolmark N, Yothers G, O'Connell MJ, et al: A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP Protocol C-08. J Clin Oncol 27:, 2009 (abstr LBA4)
    • (2009) J Clin Oncol , vol.27
    • Wolmark, N.1    Yothers, G.2    O'Connell, M.J.3
  • 18
    • 36348951548 scopus 로고    scopus 로고
    • New approaches in angiogenic targeting for colorectal cancer
    • Prat A, Casado E, Cortes J: New approaches in angiogenic targeting for colorectal cancer. World J Gastroenterol 13:5857-5866, 2007
    • (2007) World J Gastroenterol , vol.13 , pp. 5857-5866
    • Prat, A.1    Casado, E.2    Cortes, J.3
  • 19
    • 67649262706 scopus 로고    scopus 로고
    • Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial
    • (May; abstr 4027)
    • Tang P, Cohen SJ, Bjarnason GA, et al: Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): a PMH phase II consortium trial. J Clin Oncol 26: 2008 (May 20 suppl; abstr 4027)
    • (2008) J Clin Oncol , vol.26 , Issue.20 SUPPL.
    • Tang, P.1    Cohen, S.J.2    Bjarnason, G.A.3
  • 20
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1) 2005 ASCO Annual Meeting Proceedings
    • (abstr LBA3)
    • Hecht JR, Trarbach T, Jaeger E, et al: A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1) 2005 ASCO Annual Meeting Proceedings. J Clin Oncol 23:16S, 2005 (abstr LBA3)
    • (2005) J Clin Oncol , vol.23
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3
  • 21
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz LB, Rosen LS, Marshall JL, et al: Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 25:4793-4799, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 4793-4799
    • Saltz, L.B.1    Rosen, L.S.2    Marshall, J.L.3
  • 22
    • 34347235531 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
    • Rosen LS, Kurzrock R, Mulay M, et al: Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 25:2369-76, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 2369-2376
    • Rosen, L.S.1    Kurzrock, R.2    Mulay, M.3
  • 23
    • 34547681379 scopus 로고    scopus 로고
    • Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • Drevs J, Siegert P, Medinger M, et al: Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J Clin Oncol 25:3045-3054, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 3045-3054
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 25
    • 33749018813 scopus 로고    scopus 로고
    • Clinical implications of the mechanism of epidermal growth factor receptor inhibitors
    • Marshall J: Clinical implications of the mechanism of epidermal growth factor receptor inhibitors. Cancer 107:1207-1218, 2006
    • (2006) Cancer , vol.107 , pp. 1207-1218
    • Marshall, J.1
  • 26
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 27
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ, Sr., et al: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201-1208, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3
  • 28
    • 33745909120 scopus 로고    scopus 로고
    • Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer
    • Gibson TB, Ranganathan A, Grothey A: Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer. Clin Colorectal Cancer 6:29-31, 2006
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 29-31
    • Gibson, T.B.1    Ranganathan, A.2    Grothey, A.3
  • 29
    • 42049092269 scopus 로고    scopus 로고
    • Interim results from PACCE: Irinotecan (Iri)/bevacizumab (bev) ± panitumumab (pmab) as firstline treatment (tx) for metastatic colorectal cancer (mCRC)
    • (abstr 279)
    • Hecht JR, Mitchell E, Chidiac T, et al: Interim results from PACCE: irinotecan (Iri)/bevacizumab (bev) ± panitumumab (pmab) as firstline treatment (tx) for metastatic colorectal cancer (mCRC), 2008 Gastrointestinal Cancers Symposium, 2008 (abstr 279)
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 30
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A, Bachet JB, Boige V, et al: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 26:374-379, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3
  • 31
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26:1626-1634, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 32
    • 33646502663 scopus 로고    scopus 로고
    • Phase II trial of R115777 (NSC #70818) in patients with advanced colorectal cancer: A Southwest Oncology Group study
    • Whitehead RP, McCoy S, Macdonald JS, et al: Phase II trial of R115777 (NSC #70818) in patients with advanced colorectal cancer: a Southwest Oncology Group study. Invest New Drugs 24:335-341, 2006
    • (2006) Invest New Drugs , vol.24 , pp. 335-341
    • Whitehead, R.P.1    McCoy, S.2    Macdonald, J.S.3
  • 33
    • 34250619165 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
    • Abraham RT, Gibbons JJ: The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res 13:3109-3114, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 3109-3114
    • Abraham, R.T.1    Gibbons, J.J.2
  • 34
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356:2271-2281, 2007
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 35
    • 43249131245 scopus 로고    scopus 로고
    • Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero J, Rojo F, Calvo E, et al: Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 26:1603-1610, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1603-1610
    • Tabernero, J.1    Rojo, F.2    Calvo, E.3
  • 36
    • 0038688097 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors
    • Punt CJ, Boni J, Bruntsch U, et al: Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors. Ann Oncol 14:931-937, 2003
    • (2003) Ann Oncol , vol.14 , pp. 931-937
    • Punt, C.J.1    Boni, J.2    Bruntsch, U.3
  • 37
    • 34250902930 scopus 로고    scopus 로고
    • Targeting the protein kinase C family: Are we there yet?
    • Mackay HJ, Twelves CJ: Targeting the protein kinase C family: are we there yet? Nat Rev Cancer 7:554-562, 2007
    • (2007) Nat Rev Cancer , vol.7 , pp. 554-562
    • Mackay, H.J.1    Twelves, C.J.2
  • 38
    • 36549083728 scopus 로고    scopus 로고
    • A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors
    • Camidge DR, Gail Eckhardt S, Gore L, et al: A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors. Anticancer Drugs 19:77-84, 2008
    • (2008) Anticancer Drugs , vol.19 , pp. 77-84
    • Camidge, D.R.1    Gail Eckhardt, S.2    Gore, L.3
  • 39
    • 33748670455 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
    • Carducci MA, Musib L, Kies MS, et al: Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J Clin Oncol 24:4092-4099, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 4092-4099
    • Carducci, M.A.1    Musib, L.2    Kies, M.S.3
  • 40
    • 67649659372 scopus 로고    scopus 로고
    • Phase I study of enzastaurin (ENZ) and bevacizumab (BV) in patients with advanced cancer
    • (May 20), (abstr 3529)
    • Resta LP, Ermisch S, Collins C, et al: Phase I study of enzastaurin (ENZ) and bevacizumab (BV) in patients with advanced cancer. J Clin Oncol 26(May 20 suppl): 2008 (abstr 3529)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Resta, L.P.1    Ermisch, S.2    Collins, C.3
  • 41
    • 33645072205 scopus 로고    scopus 로고
    • Treatment for advanced tumors: SRC reclaims center stage
    • Summy JM, Gallick GE: Treatment for advanced tumors: SRC reclaims center stage. Clin Cancer Res 12:1398-1401, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 1398-1401
    • Summy, J.M.1    Gallick, G.E.2
  • 42
    • 36048947549 scopus 로고    scopus 로고
    • Phase I study of AZD0530, an oral potent inhibitor of Src kinase: First demonstration of inhibition of Src activity in human cancers
    • (abstr 3520)
    • Tabernero J, Cervantes A, Hoekman K, et al: Phase I study of AZD0530, an oral potent inhibitor of Src kinase: first demonstration of inhibition of Src activity in human cancers. J Clin Oncol 25:18S, 2007 (abstr 3520)
    • (2007) J Clin Oncol , vol.25
    • Tabernero, J.1    Cervantes, A.2    Hoekman, K.3
  • 43
    • 0035433029 scopus 로고    scopus 로고
    • Past and future of the mitotic spindle as an oncology target
    • Wood KW, Cornwell WD, Jackson JR: Past and future of the mitotic spindle as an oncology target. Curr Opin Pharmacol 1:370-377, 2001
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 370-377
    • Wood, K.W.1    Cornwell, W.D.2    Jackson, J.R.3
  • 44
    • 35349018479 scopus 로고    scopus 로고
    • ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism
    • Luo L, Parrish CA, Nevins N, et al: ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol 3:722-726, 2007
    • (2007) Nat Chem Biol , vol.3 , pp. 722-726
    • Luo, L.1    Parrish, C.A.2    Nevins, N.3
  • 45
    • 20344406651 scopus 로고    scopus 로고
    • Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV Q 21 days
    • (abstr 2078)
    • Chu QS, Holen KD, Rowinsky ED, et al: Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV Q 21 days. J Clin Oncol 22:14S, 2004 (abstr 2078)
    • (2004) J Clin Oncol , vol.22
    • Chu, Q.S.1    Holen, K.D.2    Rowinsky, E.D.3
  • 46
    • 13344275252 scopus 로고    scopus 로고
    • Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV days 1, 8, 15 q 28 days
    • (abstr 2004)
    • Burris HA, Lorusso P, Jones S, et al: Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV days 1, 8, 15 q 28 days. J Clin Oncol 22:128, 2004 (abstr 2004)
    • (2004) J Clin Oncol , vol.22 , pp. 128
    • Burris, H.A.1    Lorusso, P.2    Jones, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.