In vitro and in vivo evaluation of chemically modified degradable starch microspheres for topical haemostasis

Acta Biomaterialia

Volumn 7, Issue 6, 2011, Pages 2558-2565

  Björses, Katarina ^a   Faxälv, Lars ^b   Montan, Carl ^a   Wildt Persson, Katarina ^c   Fyhr, Peter ^c   Holst, Jan ^a   Lindahl, Tomas L ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c Magle Life Sciences   (Sweden)

Author keywords

Degradable starch microspheres; Experimental bleeding model; Platelet adhesion; Thrombin generation; Topical haemostasis

Indexed keywords

ADHESION; CHEMICAL MODIFICATION; CHLORINE COMPOUNDS; COAGULATION; CROSSLINKING; DRUG DELIVERY; ENZYMES; MICROSPHERES; STARCH;

BLEEDINGS; DEGRADABLE STARCH MICROSPHERE; EXPERIMENTAL BLEEDING MODEL; HAEMOSTASIS; IN-VITRO; IN-VIVO; PLATELETS ADHESIONS; STARCH MICROSPHERES; THROMBIN GENERATION; TOPICAL HEMOSTASIS;

PLATELETS;

ACETIC ANHYDRIDE; CHLORIDE; CHLOROACETIC ACID; DEGRADABLE STARCH MICROSPHERE; DIETHYLAMINOETHYL CHLORIDE; ELLAGIC ACID; HEMOSTATIC AGENT; SUCCINIC ANHYDRIDE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; HEMOSTASIS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY HEMORRHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION;

RATTUS;

EID: 79955636561     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.03.003     Document Type: Article

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