What is the role of antigen-processing mechanisms in autologous tolerogenic dendritic cell therapy in organ transplantation?

Immunotherapy

Volumn 3, Issue 4 SUPPL., 2011, Pages 12-14

  Hill, Marcelo ^a,b,c,d   Segovia, Mercedes ^a,b,c   Cuturi, Maria Cristina ^a,b,c  

^a INSERM   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

autologous dendritic cells; cell therapy; tolerogenic; transplantation

Indexed keywords

CALCINEURIN INHIBITOR; CD40 ANTIGEN; CD40 LIGAND; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; IMMUNOSUPPRESSIVE AGENT; LF 150195; UNCLASSIFIED DRUG;

ARTICLE; CELL THERAPY; CYTOKINE PRODUCTION; DENDRITIC CELL; DONOR; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART GRAFT; HUMAN; IMMUNOREGULATION; IMMUNOTHERAPY; IN VIVO STUDY; LEUKOCYTE; LOW DRUG DOSE; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SURVIVAL TIME;

ANIMALS; ANTIGEN PRESENTATION; DENDRITIC CELLS; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; IMMUNOMODULATION; ORGAN TRANSPLANTATION; TISSUE THERAPY; TRANSPLANTATION, AUTOLOGOUS;

EID: 79955632298     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.11.40     Document Type: Article

References (16)

1. Dantal J, Hourmant M, Cantarovich D et al.: Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Lancet 351(9103), 623-628 (1998). (Pubitemid 28098444)
2. Bluestone JA, Thomson AW, Shevach EM, Weiner HL: What does the future hold for cell-based tolerogenic therapy? Nat. Rev. Immunol. 7(8), 650-654 (2007). (Pubitemid 47123553)
3. Morelli AE, Thomson AW: Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 7(8), 610-621 (2007). (Pubitemid 47123548)
4. Peche H, Trinite B, Martinet B, Cuturi MC: Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am. J. Transplant. 5(2), 255-267 (2005). (Pubitemid 40179512)
5. Beriou G, Peche H, Guillonneau C, Merieau E, Cuturi MC: Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 79(8), 969-972 (2005). (Pubitemid 40586872)
6. Moreau A, Hill M, Thebault P et al.: Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and non-human primates. FASEB J. 23(9), 3070-3077 (2009).
7. Segovia M, Cuturi MC, Hill M: Preparation of mouse bone marrow-derived dendritic cells with immunoregulatory properties. Methods Mol. Biol. 677, 161-168 (2011).
8. Hill M, Cuturi MC: Negative vaccination by tolerogenic dendritic cells in organ transplantation. Curr. Opin. Organ. Transplant. 15(6), 738-743 (2010).
9. Lutz MB, Suri RM, Niimi M et al.: Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. 30(7), 1813-1822 (2000). (Pubitemid 30456177)
10. Garrovillo M, Ali A, Depaz HA et al.: Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells. Am. J. Transplant. 1(2), 129-137 (2001). (Pubitemid 33674152)
11. Lu L, Li W, Fu F et al.: Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 64(12), 1808-1815 (1997).
12. Divito SJ, Wang Z, Shufesky WJ et al.: Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood 116(15), 2694-2705 (2010).
13. Yang J, Bernier SI, Ichim TE et al.: LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kB signaling through inhibition of IKK activity. J. Leukoc. Biol. 74(3), 438-447 (2003). (Pubitemid 38040405)
14. Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC: NK cells promote transplant tolerance by killing donor antigen-presenting cells. J. Exp. Med. 203(8), 1851-1858 (2006). (Pubitemid 44188459)
15. Josien R, Heslan M, Brouard S, Soulillou JP, Cuturi MC: Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 92(12), 4539-4544 (1998). (Pubitemid 29005854)
16. Lee YR, Yang IH, Lee YH et al.: Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells. Blood 105(10), 3951-3955 (2005).