Identification of a novel and potent inhibitor of phospholipase A 2 in a medicinal plant: Crystal structure at 1.93 Å and Surface Plasmon Resonance analysis of phospholipase A2 complexed with berberine

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1814, Issue 5, 2011, Pages 657-663

  Chandra, D Naveen ^a   Prasanth, G K ^a   Singh, Nagendra ^b   Kumar, Sanjit ^b   Jithesh, O ^b   Sadasivan, C ^a   Sharma, Sujatha ^b   Singh, Tej P ^b   Haridas, M ^a  

^a KANNUR UNIVERSITY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Berberine; Phospholipase A2 inhibition; Surface Plasmon Resonance; X ray crystallography

Indexed keywords

BERBERINE; GLYCINE; HISTIDINE; HYDROGEN; PHOSPHOLIPASE A2;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIOSPERMUM HALICACABUM; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFRACTION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BERBERINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; PHOSPHOLIPASES A; PROTEIN STRUCTURE, SECONDARY; RUSSELL'S VIPER; SAPINDACEAE; SURFACE PLASMON RESONANCE;

CARDIOSPERMUM HALICACABUM; VIPERINAE;

EID: 79955632256     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2011.03.002     Document Type: Article

References (29)

1. K.M. Nadkarni Indian Materia Medica 1976 Popular Book Depot Mumbai
2. K.R. Kirthikar, B.D. Basu, and I.C.S. Ann Indian Medicinal Plants, Vol. I second ed 1969 Periodical Experts New Delhi
3. A.K. Dass Chemical examination of Cardiospermum halicacabum Bull. Botanical Survey India 8 1966 357
4. M.J. Chisholm, and C.Y. Hopkins Fatty acids of the seed oil of Cardiospermum halicacabum Can. J. Chem. 36 1958 1537 1540
5. A. Tifikar, and A. Musthaq Chemical investigation of the genus Cardiospermum Sci. International. 5 1993 67 69
6. C.V. Rao, and D. Gunasekhar Chemical examination of Cardiospermum halicacabum Acta Indica. Chem. B. 1987 169 170
7. C. Gopalakrishnan, R. Dananjayan, and L. Kameshwaran Pharmacological actions of Cardiospermum halicacabum Ind. J. Physiol. Pharmacol. 20 1976 203 208
8. W.H. Lewis, and E. Lewis Immune system and cell modifiers Medical Botany Second Edition 2003 Wiley Publishers New York
9. M. Daniel Medicinal Plants: Chemistry and Properties 2006 Science Publishers Plymouth, U.K
10. K.B. Desai, and S. Sethna Chemical investigation of the roots of the Indian medicinal plant, Cardiospermum halicacabum Chem. abstracts. 50 1954 391
11. J. Sadique, T. Chandra, V. Thenmozhi, and V. Elango Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation J. Ethnopharmacol. 19 1987 201 212 (Pubitemid 17083781)
12. S. Raghupathy, S.G. Newmaster, P. Gopinathan, and C.B. Newmaster Exploring ethnobiological classifications for novel alternative medicine: a case study of Cardiospermum halicacabum as a traditional herb for treating rheumatoid arthritis Ethnobotany 19 2007 1 18
13. W.L. Smith Prostanoid biosynthesis and mechanisms of action Am. J. Physiol. Ren. Physiol. 263 1992 181 191
14. 2 by minocycline and doxycycline Life Sci. 48 1991 2457 2462
15. 2 and structure based design of specific inhibitors Curr. Top. Med. Chem. 7 2007 757 764 (Pubitemid 46681840)
16. Z. Otinowiski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Meth. Enzymol. 276 1997 307 326 (Pubitemid 27085611)
17. B.W. Matthews Solvent content of protein crystals J. Mol. Biol. 33 1968 491 497
18. V. Chandra, P. Kaur, J. Jasti, C. Betzel, and T.P. Singh Regulation of catalytic function by molecular association: structure of PLA2 from Daboia Russelli Pulchella at 1.9 Å resolution Acta. Cryst. Sect. D. 57 2001 1793 1797
19. G.N. Murshadov, A.A. Vagin, and E.J. Dodson Refinement of macromolecular structures by the maximum likelihood method Acta Cryst. Sect. D. 53 1997 240 255 (Pubitemid 27235885)
20. Schrodinger. (2005). Maestro 8.0, L. L. C., New York.
21. P.C.K. Emsley Coot: model building tools for molecular graphics Acta Cryst. Sect. D. 60 2004 2126 2132
22. A. Szabo, L. Stolz, and R. Granzow Surface Plasmon Resonance and its use in biomolecular interaction analysis Curr. Opin. Struct. Biol. 5 1995 699 705
23. 2 inhibition by manoalide J. Biol. Chem. 260 1985 234 240
24. K. Brocklehurst Electrochemical assays: the pH stat Enzyme Assays: A Practical Approach 2002 Oxford University Press U.K.
25. T. Palmer, and P. Bonner Enzymes: Biochemistry, Biotechnology and Clinical Chemistry second ed 2007 Harwood Publishing U.S.A
26. Y. Cheng, and W.H. Prussoff Relationship between the inhibition constant and the concentration of inhibitor which causes 50% inhibition of an enzymatic reaction Biochem. Pharmacol. 22 1973 3099 3108
27. D. Voet, and J.G. Voet Rates of enzymatic reactions Chapter 14, Biochemistry third ed 2004 John Wiley and Sons U.S.A
28. 2 and oxyphenbutazone at 1.6 Å resolution Biochemistry 43 2004 14577 14583 (Pubitemid 39524933)
29. C.L. Kuo, C.W. Chi, and T.Y. Lin The anti-inflammatory potential of berberine in vitro and in vivo Cancer Lett. 203 2004 127 137