Structural elements of ligand recognition site in secretory phospholipase A2 and structure-based design of specific inhibitors

Current Topics in Medicinal Chemistry

Volumn 7, Issue 8, 2007, Pages 757-764

  Singh, Nagendra ^a   Somvanshi, Rishi K ^a   Sharma, Sujata ^a   Dey, Sharmistha ^a   Kaur, Punit ^a   Singh, Tej P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Binding affinity; Complexes; Crystal structures; Enzyme; Hydropholic channel; Inflammation; Inhibitors; PLA2; Subsites

Indexed keywords

2 CARBAMOYLMETHYL 5 PROPYLOCTAHYDROINDOL 7 YL ACETIC ACID; ASPARTIC ACID; DICLOFENAC; HISTIDINE; INDOLE DERIVATIVE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; BINDING AFFINITY; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; INFLAMMATION; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PHOSPHOLIPASES A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247640068     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607780487669     Document Type: Review

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