Particle aerosolisation and break-up in dry powder inhalers: Evaluation and modelling of impaction effects for agglomerated systems

Journal of Pharmaceutical Sciences

Volumn 100, Issue 7, 2011, Pages 2744-2754

  Wong, William ^a   Fletcher, David F ^a   Traini, Daniela ^a   Chan, Hak kim ^a   Crapper, John ^b   Young, Paul M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Pharmaxis Ltd   (Australia)

Author keywords

Aerosols; Agglomerate; CFD; Deagglomeration; Dry powder inhaler; Impaction; In silico modelling; Particle size; Pulmonary drug delivery; Simulations

Indexed keywords

MANNITOL;

AEROSOL; ARTICLE; CHEMICAL ANALYSIS; COMPUTATIONAL FLUID DYNAMICS; COMPUTER MODEL; CONTROLLED STUDY; DRUG FORMULATION; DRY POWDER; FLOW RATE; LASER DIFFRACTION; POWDER INHALER; SIMULATION; SUSPENDED PARTICULATE MATTER;

EID: 79955631842     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22503     Document Type: Article

References (15)

1. Pritchard JN. 2001. The influence of lung deposition on clinical response. J Aerosol Med 14:S19-S26.
2. Young PM, Traini D, Edge S. 2007. Advances in pulmonary therapy. In Advanced drug formulation design to optimize therapeutic outcomes; Williams RO, Taft DT, McConville JT, Eds. London: Informa Healthcare, pp 1-51.
3. Smith IJ, Parry-Billings M. 2003. The inhalers of the future? A review of dry powder devices on the market today. Pulm Pharmacol Ther 16:79-95.
4. Newman SP, Busse WW. 2002. Evolution of dry powder inhaler design, formulation, and performance. Resp Med 96:293-304.
5. Islamand N, Gladki E. 2008. Dry powder inhalers (DPIs)-A review of device reliability and innovation. Int J Pharm 360:1-11.
6. Voss A, Finlay WH. 2002. Deagglomeration of dry powder pharmaceutical aerosols. Int J Pharm 248:39-50.
7. Wang ZL, Lange CF, Finlay WH. 2004. Use of an impinging jet for dispersion of dry powder inhalation aerosols. Int J Pharm 275:123-131.
8. Louey MD, Van Oort M, Hickey AJ. 2006. Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion. J Aerosol Sci 37:1520-1531.
9. Calvert G, Ghadiri M, Tweedie R. 2009. Aerodynamic dispersion of cohesive powders: A review of understanding and technology. Adv Powder Technol 20:4-16.
10. Wong W, Fletcher DF, Traini D, Chan HK, Crapper J, Young PM. 2010. Particle aerosolisation and break-up in dry powder inhalers 1: Evaluation and modelling of venturi effects for agglomerated systems. Pharm Res 27:1367-1376.
11. Wong W, Crapper J, Chan HK, Traini D, Young PM. 2010. Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. J Pharm Biomed Anal 51:853-857.
12. Bhattacharya S, Mittal KL. 1978. Mechanics of removing glass particulates from a solid-surface. Surf Technol 7:413-425.
13. Ning Z, Boerefijn R, Ghadiri M, Thornton C. 1997. Distinct element simulation of impact breakage of lactose agglomerates. Adv Powder Technol 8:15-37.
14. Boerefijn R, Ning Z, Ghadiri M. 1998. Disintegration of weak lactose agglomerates for inhalation applications. Int J Pharm 172:199-209.
15. Tong ZB, Yang RY, Yu AB, Adi S, Chan HK. 2009. Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technol 196:213-221.