Varicocele correction for infertility: Which patients to treat?

International Journal of Andrology

Volumn 34, Issue 3, 2011, Pages 236-241

  Giagulli, V A ^a,b   Carbone, M D ^c,d  

^a Department of Internal Medicine   (Italy)

^b NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^c Institute of Clinical and Hormonal Research   (Italy)

^d Biomedical Research Association 'Guglielmo Telesforo'   (Italy)

Author keywords

(in)fertility; CAG repeat length polymorphism; Cumulative pregnancy rate; Fertility index; Follicle stimulating hormone; Varicocele; Varicocelectomy

Indexed keywords

ANDROGEN RECEPTOR;

ADULT; ARTICLE; CAG REPEAT; CONTROLLED STUDY; FERTILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPERMATOZOON MOTILITY; VARICOCELE; VARICOCELECTOMY;

ADULT; BASE COMPOSITION; FEMALE; HUMANS; INFERTILITY, MALE; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREGNANCY; PREGNANCY RATE; RECEPTORS, ANDROGEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; VARICOCELE;

EID: 79955613983     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2010.01081.x     Document Type: Article

References (41)

1. Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, Sabanegh E & Marmar JL. (2007) Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology 70, 532-538.
2. Asatiani K, Von Eckardstein S, Simoni M, Gromoll J & Nieschlag E. (2003) CAG repeat length in androgen receptor gene affects the risk of male infertility. Int J Androl 26, 255-261.
3. Benoff S & Gilbert BR. (2001) Varicocele and male infertility: part I. Preface. Hum Reprod Update 7, 47-54.
4. Cayan S, Erdemir F, Ozbey I, Turek PJ, Kadioǧlu A & Tellaloǧlu S. (2002) Can varicocelectomy significantly chance the way couples use assisted reproductive technologies? J Urol 167, 1749-1752.
5. Cayan S, Shavakhabov S & Kadioǧlu A. (2009) Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. J Androl 30, 33-40.
6. Cocuzza M, Cocuzza MA, Papa Bragais FM & Agarwal A. (2008) The role of varicocele repair in the new era of assisted reproductive technology. Clinics 63, 395-404.
7. Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW et al. (2010) The EMAS group. Age related changes in general and sexual health in middle-aged and older men: results from the European Male Aging Study (EMAS). J Sex Med 7, 1362-1380.
8. Davis-Dao CA, Tuazon ED, Sokol RZ & Cortessis VK. (2007) Male infertility and variation in CAG repeat length in androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab 92, 4319-4326.
9. Devroey P, Fauser BCJM, Diedrich K & behalf of Evian Annual Reproduction (EVAR) Workshop Group 2008 (2009) Approaches to improve the diagnosis and management of infertility. Hum Reprod Update 15, 391-408.
10. Dohle GR, Colpi GM, Hargeave TB, Papp GK, Jungwirth A & Weidner W. (2005) The EAU Working Group on male infertility. EAU Guidelines on male infertility. Eur Urol 48, 703-711.
11. Evers JL & Collins JA. (2004) Surgery or embolisation for varicocele in infertile men. Cochrane Database Syst Rev 3, CD000479.
12. Evers JL, Collins JA & Vanderkerckhove P. (2001) Surgery or embolisation for varicocele in infertile men. Cochrane Database Syst Rev 1, CD000479.
13. Evers JL, Collins JA & Clark J. (2008) Surgery or embolisation for varicocele in infertile men. Cochrane Database Syst Rev 3, CD000479.
14. Evers JL, Collins JA & Clark J. (2009) Surgery or embolisation for varicocele in infertile men. Cochrane Database Syst Rev 1, CD000479.
15. Ficarra V, Cerruto MA, Liguori G, Mazzoni G, Minucci S, Tracia A. & Gentile V. (2006) Treatment of varicocele in subfertile men: the Cochrane review - a contrary opinion. Eur Urol 49, 258-262.
16. Forti G & Kausz C. (1998) Clinical Review 100: evaluation and treatment of the infertile couple. J Clin Endocrinol Metab 83, 4177-4188.
17. French DB, Desai NR & Agarwal A. (2008) Varicocele repair: does it still have a role in infertility treatment? Curr Opin Obstet Gynecol 20, 269-274.
18. Gnoth C, Godehardt E, Frank-Hermann P, Friol K, Tiggers J & Freundl G. (2005) Definition and prevalence of subfertility and infertility. Hum Reprod 20, 1144-1147.
19. Kondo Y, Ishikawa T, Yamaguchi K & Fujisawa M. (2009) Predictors of improved seminal characteristics by varicocele repair. Andrologia 41, 20-23.
20. Lee J, Binsaleh S, Lo K & Jarvi K. (2008) Varicoceles: the diagnostic dilemma. J Androl 29, 143-146.
21. Lemcke B, Behre HM & Nieschlag E. (1997) Frequently subnormal semen profiles of normal volunteers recruited over 17years. Int J Androl 20, 144-150.
22. Lindau ST, Shumm LP, Laumann EO, Levinson W, O'Muircheartaigh CA & Waite LJ. (2007) A study of sexuality and health among older adults in the United States. N Engl J Med 357, 762-774.
23. Marmar JL, Agarwal A, Prabakaran S, Agarwal R, Short RA, Benoff S & Thomas AJ, Jr. (2007) Reassessing the value of varicocelectomy as treatment for male subfertility with a new meta-analysis. Fertil Steril 88, 639-648.
24. National Collaborating Centre for Women's and Children's Health. (2004) Fertility Guideline: Assessment and Treatment for People with Infertility Problems (Second Draft). Available at: .
25. Naughton CK, Nangia AK & Agarwal A. (2001) Pathophysiology of varicoceles in male infertility. Hum Reprod Update 7, 473-481.
26. Nieschlag E, Herle I, Fischedick A, Abshagen K & Behre HM. (1998) Update on treatment of varicocele: counselling as effective as occlusion of the vena spermatica. Hum Reprod Update 13, 2147-2150.
27. Nistal M, Gonzalez-Peramato P, Serrano A & Regadera J. (2004) Physiopathology of infertile testicle. Etiopathogenesis of varicocele. Arch Esp Urol 57, 883-904.
28. Pinto KJ, Kroovand RL & Jarow JP. (1994) Varicocele related testicular atrophy and its predictive effect upon fertility. J Urol 152(2 Pt 2), 788-790.
29. The Practice Committee of the American Society for Reproductive Medicine. (2008) Reporting on varicocele and fertility. Fertil Steril 90, S242-S249.
30. Rowe T. (2006) Fertility and woman's age. J Reprod Med 51, 157-163.
31. Silber SJ. (2001) The varicocele dilemma. Hum Reprod Update 7, 70-77.
32. Vazquez-Levin MH, Friedmann P, Goldberg SI, Medley NE & Nagler HM. (1997) Response of routine semen analysis and critical assessment of sperm morphology by Kruger classification to therapeutic varicocelectomy. J Urol 158, 1804-1807.
33. Vermeulen A. (1988) Verbetert varicocele corrctie de fertiliteit. Verh. Koninkl Acad. Geneeskunde van Belgie L2, 139-150.
34. Wagner L & Tostain J. (2007) Comite Andrologie de l'Association Française d'Urologie Varicocele and male infertility: AFU 2006 guidelines. Prog Urol 17, 12-17.
35. Weidner W, Colpi GM, Hargeave TB, Papp CK, Pomerol JM & Ghosh C. (2002) The EAU Working Group on male infertility. EAU Guidelines on male infertility. Eur Urol 42, 313-322.
36. World Health Organization. (1992) The influence of varicocele parameters on infertility in a large group of men presenting to infertility clinics. Fertil Steril 57, 1289-1293.
37. World Health Organization. (1999) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, Cambridge, UK.
38. World Health Organization. (2000) Manual for the Standardized Investigation and Diagnosis of Infertile Couples. Cambridge University Press, Cambridge, UK.
39. Zini A, Boman J, Baazeen A, Jarvi K & Libman J. (2008) Natural history of varicocele management in the era of intracytoplasmic sperm injection. Fertil Steril 90, 2251-2256.
40. Zitzmann M & Nieschlag E. (2003) The CAG repeat polymorphism within the androgen receptor gene and maleness. Int J Androl 26, 76-83.
41. Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V & Porena M. (2006) Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. J Androl 27, 541-551.