Phosphate, oxidative stress, and nuclear factor-B activation in vascular calcification

Kidney International

Volumn 79, Issue 10, 2011, Pages 1044-1047

  Al Aly, Ziyad ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Epidemiology Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOPONTIN; PHOSPHATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR PIT 1; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; BLOOD VESSEL CALCIFICATION; ENZYME SYNTHESIS; HOMEOSTASIS; HUMAN; KIDNEY DISEASE; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PHENOTYPE; PHOSPHATE BLOOD LEVEL; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION; VASCULAR SMOOTH MUSCLE;

EID: 79955609351     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.548     Document Type: Note

References (10)

1. Al-Aly Z. The new role of calcimimetics as vasculotropic agents. Kidney Int 2009; 75: 9-12.
2. Al-Aly Z. Metabolic acidosis and vascular calcification: using blueprints from bone to map a new venue for vascular research. Kidney Int 2008; 73: 377-379. (Pubitemid 351186296)
3. Giachelli CM. The emerging role of phosphate in vascular calcification. Kidney Int 2009; 75: 890-897.
4. Shroff RC, McNair R, Skepper JN et al. Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol 2010; 21: 103-112.
5. Byon CH, Javed A, Dai Q et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem 2008; 283: 15319-15327.
6. Miller JD, Chu Y, Brooks RM et al. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008; 52: 843-850.
7. Zhao M -M, Xu M-J, Cai Y et al. Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo. Kidney Int 2011; 79: 1071-1079.
8. Al-Aly Z. Arterial calcification: a tumor necrosis factor-alpha mediated vascular Wnt-opathy. Transl Res 2008; 151: 233-239. (Pubitemid 351545863)
9. Al-Aly Z, Shao JS, Lai CF et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alphadependent signals in diabetic Ldlr / mice. Arterioscler Thromb Vasc Biol 2007; 27: 2589-2596. (Pubitemid 350158910)
10. Shao JS, Aly ZA, Lai CF et al. Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification. Ann NY Acad Sci 2007; 1117: 40-50