Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2083-2090

  Rizzi, Luca ^a   Sundararaman, Srividhya ^b   Cendic, Katarina ^a   Vaiana, Nadia ^a   Korde, Reshma ^b   Sinha, Dipto ^b   Mohmmed, Asif ^b   Malhotra, Pawan ^b   Romeo, Sergio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Cystatin; Falcipain 2; Malaria; Protein protein interaction mimics

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID DERIVATIVE; ANTIMALARIAL AGENT; CYSTATIN; CYSTEINE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; PEPTIDE;

ARTICLE; CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PLASMODIUM; PROTEIN PROTEIN INTERACTION;

CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PEPTIDES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955601045     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.061     Document Type: Article

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