Protective role of HO-1 for alcohol-dependent liver damage

Digestive Diseases

Volumn 28, Issue 6, 2010, Pages 792-798

  Nussler, A K ^a,e   Hao, L ^a,d   Knobeloch, D ^b   Yao, P ^b,d   Nussler, N C ^c   Wang, Z ^a   Liu, L ^d   Ehnert, S ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Klinikum Neuperlach   (Germany)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Hepatocytes; HO 1; Oxidative stress; Quercetin

Indexed keywords

ALCOHOL; GLUTATHIONE; HEME OXYGENASE 1; HEMIN; LACTATE DEHYDROGENASE; LYMPHOTOXIN; NIFEDIPINE; POLYPHENOL; QUERCETIN; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NRF2; VERAPAMIL;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; APOPTOSIS; ARTICLE; CELL DAMAGE; HUMAN; HUMAN TISSUE; INCUBATION TEMPERATURE; LIVER INJURY; NECROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

BUFFERS; CYTOPROTECTION; ETHANOL; FLAVONOIDS; HEME OXYGENASE-1; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE; LIVER DISEASES, ALCOHOLIC; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PHENOLS; PROTECTIVE AGENTS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 79955589090     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000324287     Document Type: Article

References (21)

1. Cederbaum AI, Lu Y, Wu D: Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol 2009; 83: 519-548.
2. Siegmund SV, Dooley S, Brenner DA: Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis 2005; 23: 264-274. (Pubitemid 43325926)
3. Farfan Labonne BE, Gutierrez M, Gomez- Quiroz LE, Konigsberg Fainstein M, Bucio L, Souza V, Flores O, Ortiz V, Hernandez E, Kershenobich D, Gutierrez-Ruiz MC: Acetaldehyde- induced mitochondrial dysfunction sensitizes hepatocytes to oxidative damage. Cell Biol Toxicol 2009; 25: 599-609.
4. Lakshmi Devi S, Anuradha CV: Mitochondrial damage, cytotoxicity and apoptosis in iron-potentiated alcoholic liver fibrosis: amelioration by taurine. Amino Acids 2010; 38: 869-879.
5. Liu LG, Yan H, Yao P, Zhang W, Zou LJ, Song FF, Li K, Sun XF: CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes. World J Gastroenterol 2005; 11: 4530-4535. (Pubitemid 41150394)
6. Garcia-Ruiz C, Fernandez-Checa JC: Mitochondrial glutathione: hepatocellular survival- death switch. J Gastroenterol Hepatol 2006; 21(suppl 3):S3-S6. (Pubitemid 44266539)
7. Sastre J, Serviddio G, Pereda J, Minana JB, Arduini A, Vendemiale G, Poli G, Pallardo FV, Vina J: Mitochondrial function in liver disease. Front Biosci 2007; 12: 1200-1209. (Pubitemid 46846825)
8. Albano E, Vidali M: Immune mechanisms in alcoholic liver disease. Genes Nutr 2009.
9. Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S: TGF-β enhances alcohol-dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol 2010; 52: 407-416.
10. Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernandez M, Fabregat I: Upregulation of the NADPH oxidase NOX4 by TGF-β in hepatocytes is required for its pro-apoptotic activity. J Hepatol 2008; 49: 965-976.
11. Angeloni C, Leoncini E, Malaguti M, Angelini S, Hrelia P, Hrelia S: Role of quercetin in modulating rat cardiomyocyte gene expression profile. Am J Physiol Heart Circ Physiol 2008; 294:H1233-H1243. (Pubitemid 351468719)
12. Hu JY, Huang YS, Song HP, Zhang DX, Xiang F, Zhu ZG, Teng M, Zhang Q: Protective effects of astragaloside and quercetin on rat myocardial cells after hypoxia (in Chinese). Zhonghua Shao Shang Za Zhi 2007; 23: 175-178. (Pubitemid 47249493)
13. Opie LH, Lecour S: The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J 2007; 28: 1683-1693. (Pubitemid 47227092)
14. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, Zhang X, Nussler A, Liu L: Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol 2010; 128: 549-553.
15. Yao P, Li K, Song F, Zhou S, Sun X, Zhang X, Nussler AK, Liu L: Heme oxygenase-1 upregulated by Ginkgo biloba extract: potential protection against ethanol-induced oxidative liver damage. Food Chem Toxicol 2007; 45: 1333-1342. (Pubitemid 47033946)
16. Yao P, Nussler A, Liu L, Hao L, Song F, Schirmeier A, Nussler N: Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol 2007; 47: 253-261. (Pubitemid 47023137)
17. Farombi EO, Surh YJ: Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 2006; 39: 479-491. (Pubitemid 44714527)
18. Liu LG, Yan H, Zhang W, Yao P, Zhang XP, Sun XF, Nussler AK: Induction of heme oxygenase- 1 in human hepatocytes to protect them from ethanol-induced cytotoxicity. Biomed Environ Sci 2004; 17: 315-326. (Pubitemid 39486798)
19. Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, Brulport M, Gabelein G, Schormann W, Schulze M, Ellis E, Kraemer M, Nocken F, Fleig W, Manns M, Strom SC, Hengstler JG: Present status and perspectives of cell-based therapies for liver diseases. J Hepatol 2006; 45: 144-159. (Pubitemid 44183679)
20. Gough NM: Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Anal Biochem 1988; 173: 93-95.
21. Gong P, Hu B, Cederbaum AI: Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch Biochem Biophys 2004; 432: 252-260. (Pubitemid 39470021)