Protective effects of aqueous and ethanolic extracts of saffron stigma and petal on liver toxicity induced by carbon tetrachloride in mice

Pharmacologyonline

Volumn 1, Issue , 2011, Pages 203-212

  Iranshahi, Milad ^a   Khoshangosht, Mostafa ^a   Mohammadkhani, Zahra ^a   Karimi, Gholamreza ^a  

^a School of Pharmacy   (Iran)

Author keywords

Carbon tetra chloride (CCl4) and hepatotoxicity; Saffron petal; Saffron stigma

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ANTHOCYANIN; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CROCUS SATIVA EXTRACT; CYTOCHROME P450; FLAVONOID; LIVER PROTECTIVE AGENT; PLANT EXTRACT; SCAVENGER; UNCLASSIFIED DRUG; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VACUOLE; CONTROLLED STUDY; CROCUS; CROCUS SATIVA; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG DOSE COMPARISON; ENZYME INHIBITION; HISTOPATHOLOGY; LIVER CELL MEMBRANE; LIVER FATTY DEGENERATION; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PETAL; PISTIL STIGMA; TOXICITY TESTING;

EID: 79955586468     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Ríos JL, Recio MC, Giner RM, Máñez S. An Update Review of Saffron and its Active Constituents. Phytotherapy Research. 1996;10(3):189-93.
2. Abe K, Sugiura M, Yamaguchi S, Shoyama Y, Saito H. Saffron extract prevents acetaldehydeinduced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res. 1999 Dec 18;851(1-2):287-9.
3. Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002 Mar 15;2:7.
4. Manibusan MK, Odin M, Eastmond DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):185-209.
5. Quan J, Yin X, Xu H. Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Exp Toxicol Pathol. 2011 Jan;63(1-2):53-9.
6. Kamalakkannan N, Rukkumani R, Varma PS, Viswanathan P, Rajasekharan KN, Menon VP. Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):15-21.
7. Ahmed B, Alam T, Khan SA. Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. [doi: DOI: 10.1016/S0378-8741(00)00402-5]. 2001;76(2):187-9.
8. Park E-J, Jeon CH, Ko G, Kim J, Sohn DH. Protective Effect of Curcumin in Rat Liver Injury Induced by Carbon Tetrachloride. Journal of Pharmacy and Pharmacology. 2000;52(4):437-40.
9. Lin C-C, Huang P-C. Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytotherapy Research. 2000;14(7):489-94.
10. Gilani A-UH, Janbaz KH. Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity. General Pharmacology: The Vascular System. [doi: DOI: 10.1016/0306-3623(94)00194-R]. 1995;26(2):309-15.
11. Gilani A-UH, Janbaz KH. Studies on protective effect of Cyperus Scariosus extract on acetaminophen and CCl4-induced hepatotoxicity. General Pharmacology: The Vascular System. [doi: DOI: 10.1016/0306-3623(94)00200-7]. 1995;26(3):627-31.
12. Ha K-T, Yoon S-J, Choi D-Y, Kim D-W, Kim J-K, Kim C-H. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology. [doi: DOI: 10.1016/j.jep.2004.09.054]. 2005;96(3):529-35.
13. Janbaz KH, Saeed SA, Gilani AH. Protective effect of rutin on paracetamol- and CCl4- induced hepatotoxicity in rodents. Fitoterapia. [doi: DOI: 10.1016/S0367-326X(02)00217-4]. 2002;73(7-8):557-63.
14. Upur H, Amat N, Blazekovic B, Talip A. Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice. Food and Chemical Toxicology. [doi: DOI: 10.1016/j.fct.2009.05.022]. 2009;47(8):2022-30.
15. Sharma N, Shukla S. Hepatoprotective potential of aqueous extract of Butea monosperma against CCl4 induced damage in rats. Experimental and Toxicologic Pathology. [doi: DOI: 10.1016/j.etp.2010.05.009].In Press, Corrected Proof.
16. Fernández J-A. Anticancer properties of saffron, Crocus sativus Linn. In: Mahmud THK, Arjumand A, editors. Advances in Phytomedicine: Elsevier; 2006. p. 313-30.
17. Bathaie SZ, Mousavi SZ. New Applications and Mechanisms of Action of Saffron and its Important Ingredients. Critical Reviews in Food Science and Nutrition. 2010;50(8):761-86.
18. Hosseinzadeh H. SFaMS. Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituent, crocin and safranal. Pharmacog Mag. 2009;5:419-24.
19. Recknagel RO, Glende EA, Jr., Dolak JA, Waller RL. Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther. 1989;43(1):139-54.
20. Ahn TH, Yang YS, Lee JC, Moon CJ, Kim SH, Jun W, et al. Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother Res. 2007 Nov;21(11):1015-9.
21. Lin CC, Huang PC. Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytother Res. 2000 Nov;14(7):489-94.
22. Chen Y, Zhang H, Tian X, Zhao C, Cai L, Liu Y, et al. Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: A relationship investigation between antioxidant activity and crocin contents. Food Chemistry. 2008;109(3):484-92.