RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis

Cell Cycle

Volumn 10, Issue 9, 2011, Pages 1456-1467

  Funasaka, Tatsuyoshi ^a   Nakano, Hiroshi ^a   Wu, Yu ^b,c   Hashizume, Chieko ^a   Gu, Ling ^d   Nakamura, Takuro ^e   Wang, Wei ^a   Zhou, Pengbo ^f   Moore, Malcolm A S ^g   Sato, Hiroshi ^a   Wong, Richard W ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b SICHUAN UNIVERSITY   (China)

^c Laboratory of Genome Stability   (China)

^d SICHUAN UNIVERSITY   (China)

^e CANCER INSTITUTE   (Japan)

^f Weill Cornell Graduate School of Biomedical Sciences   (United States)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Aneuploidy; Cancer; Chromosome; Leukemia; Nuclear pore; Nucleoporin

Indexed keywords

HISTONE DEACETYLASE 1; NUCLEOPORIN 98; RNA; RNA EXPORT FACTOR 1 HOMOLOG; TRANSCRIPTION FACTOR HOXA9; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; CELL CYCLE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; GENETIC TRANSFECTION; LEUKEMOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE;

MUS MUSCULUS;

EID: 79955585790     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.9.15494     Document Type: Article

References (47)

1. Strambio-De-Castillia C, Niepel M, Rout MP. The nuclear pore complex: Bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol 2010; 11:490-501.
2. Funasaka T, Wong RW. The role of nuclear pore complex in tumor microenvironment and metastasis. Cancer Metastasis Rev 2011; In press.
3. Nakano H, Wang W, Hashizume C, Funasaka T, Sato H, Wong RW. Unexpected role of nucleoporins in coordination of cell cycle progression. Cell Cycle 2011; 10:425-33.
4. Guttinger S, Laurell E, Kutay U. Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol 2009; 10:178-91.
5. Tran EJ, Wente SR. Dynamic nuclear pore complexes: life on the edge. Cell 2006; 125:1041-53. (Pubitemid 43866205)
6. Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, et al. NUP98 dysregulation in myeloid leukemogenesis. Ann NY Acad Sci 2007; 1106:114-42. (Pubitemid 47443055)
7. Xu S, Powers MA. Nup98-homeodomain fusions interact with endogenous Nup98 during interphase and localize to kinetochores and chromosome arms during mitosis. Mol Biol Cell 2010; 21:1585-96.
8. Moore MA. A cancer fate in the hands of a samurai. Nat Med 2010; 16:963-5.
9. Pritchard CE, Fornerod M, Kasper LH, van Deursen JM. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains. J Cell Biol 1999; 145:237-54.
10. Wong RW. Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation. Cell Cycle 2010; 9:198-200.
11. Wong RW, Blobel G. Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci USA 2008; 105:15441-5.
12. Wong RW, Blobel G, Coutavas E. Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci USA 2006; 103:19783-7. (Pubitemid 46037508)
13. Xu S, Powers MA. Nuclear pore proteins and cancer. Semin Cell Dev Biol 2009; 20:620-30.
14. Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 1996; 12:154-8. (Pubitemid 26051295)
15. Kohler A, Hurt E. Gene regulation by nucleoporins and links to cancer. Mol Cell 2010; 38:6-15.
16. Nakamura T. NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins. Int J Hematol 2005; 82:21-7. (Pubitemid 41512194)
17. Bailer SM, Siniossoglou S, Podtelejnikov A, Hellwig A, Mann M, Hurt E. Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p. EMBO J 1998; 17:1107-19. (Pubitemid 28077664)
18. Ren Y, Seo HS, Blobel G, Hoelz A. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc Natl Acad Sci USA 2010; 107:10406-11.
19. Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, et al. Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 2009; 4:6146.
20. Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 2006; 10:529-41. (Pubitemid 44854748)
21. Lu Y, Lemon W, Liu PY, Yi Y, Morrison C, Yang P, et al. A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med 2006; 3:467.
22. Blower MD, Nachury M, Heald R, Weis K. A Rae1- containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 2005; 121:223-34. (Pubitemid 40546390)
23. Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, et al. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 2007; 446:876-81.
24. Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, et al. Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell 2008; 132:771-82. (Pubitemid 351312802)
25. Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, et al. Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Blood 2005; 105:784-93. (Pubitemid 40070766)
26. Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 2001; 20:350-61. (Pubitemid 32126971)
27. de Magalhaes JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, et al. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell 2009; 8:65-72.
28. Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE. HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Mol Cell Biol 2007; 27:4207-16. (Pubitemid 46906546)
29. Shen WF, Rozenfeld S, Kwong A, Kom ves LG, Lawrence HJ, Largman C. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol Cell Biol 1999; 19:3051-61.
30. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286:531-7.
31. Bullinger L, Dohner K, Bair E, Frohling S, Schlenk RF, Tibshirani R, et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 2004; 350:1605-16. (Pubitemid 38501163)
32. Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, et al. Oncomine 3.0: genes, pathways and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 2007; 9:166-80.
33. Aoki T, Miyamoto T, Yoshida S, Yamamoto A, Yamauchi T, Yoshimoto G, et al. Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9. Int J Hematol 2008; 88:571-4.
34. Chung KY, Morrone G, Schuringa JJ, Plasilova M, Shieh JH, Zhang Y, et al. Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Cancer Res 2006; 66:11781-91. (Pubitemid 46094190)
35. Nakano H, Funasaka T, Hashizume C, Wong RW. Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem 2010; 285:10841-9.
36. Napetschnig J, Kassube SA, Debler EW, Wong RW, Blobel G, Hoelz A. Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc Natl Acad Sci USA 2009; 106: 3089-3094.
37. Hashizume C, Nakano H, Yoshida K, Wong RW. Characterization of the role of the tumor marker Nup88 in mitosis. Mol Cancer 2010; 9:119.
38. Wong RW. An update on cohesin function as a 'molecular glue' on chromosomes and spindles. Cell Cycle 2010; 9:1754-8.
39. Cohen-Fix O. Cell biology: Import and nuclear size. Nature 2010; 468:513-6.
40. Levy DL, Heald R. Nuclear size is regulated by importin alpha and Ntf2 in Xenopus. Cell 2010; 143:288-98.
41. van Zutven LJ, Onen E, Velthuizen SC, van Drunen E, von Bergh AR, van den Heuvel-Eibrink MM, et al. Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 2006; 45:437-46.
42. Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 2009; 459:847-51.
43. Strawn LA, Shen T, Wente SR. The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. J Biol Chem 2001; 276:6445-52.
44. Falini B. Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological and Clinical Features. Cancer Treat Res 2009; 145:149-68.
45. Neben K, Giesecke C, Schweizer S, Ho AD, Kramer A. Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile. Blood 2003; 101:289-91. (Pubitemid 36025920)
46. Neben K, Tews B, Wrobel G, Hahn M, Kokocinski F, Giesecke C, et al. Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes. Oncogene 2004; 23:2379-84. (Pubitemid 38496793)
47. Wong RW, Setou M, Teng J, Takei Y, Hirokawa N. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA 2002; 99:14500-5. (Pubitemid 35257700)