Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: A new class of potential antineoplastic agents

Investigational New Drugs

Volumn 29, Issue 3, 2011, Pages 434-442

  Mukherjee, Asama ^a   Hazra, Suva ^a   Dutta, Sushanta ^a   Muthiah, Shanmugavel ^b   Mondhe, Dilip Manikrao ^b   Sharma, Parduman Raj ^b   Singh, Shashank Kumar ^b   Saxena, Ajit Kumar ^b   Qazi, Gulam Nabi ^b   Sanyal, Utpal ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Apoptosis; Cell cycle; Cytotoxicity assay; Human tumor cell lines; Novel antitumor agents

Indexed keywords

6 NITRO 2 (2 CHLOROETHYL) 1H BENZ[DE]ISOQUINOLINE 1,3 DIONE; 6 NITRO 2 (3 CHLOROPROPYL) 1H BENZ[DE]ISOQUINOLINE 1,3 DIONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARMUSTINE; CHLOROALKYL 1H BENZ[DE]ISOQUINOLINE 1,3 DIONE DERIVATIVE; CISPLATIN; DOXORUBICIN; FLUOROURACIL; HYDROXYUREA; MITOMYCIN C; MITONAFIDE; N [2 (CHLOROETHYL)]NAPHTHALIMIDE DERIVATIVE; N [3 (CHLOROPROPYL)]NAPHTHALIMIDE DERIVATIVE; NAPHTHALIMIDE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RNA SYNTHESIS; SARCOMA 180; STRUCTURE ACTIVITY RELATION;

ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SHAPE; DNA, NEOPLASM; ENZYME ACTIVATION; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; ISOQUINOLINES; LEUKOCYTES, MONONUCLEAR; MICROSCOPY, ELECTRON, TRANSMISSION; NAPHTHALIMIDES; PROPIDIUM; RNA, NEOPLASM; STAINING AND LABELING; TREATMENT OUTCOME;

EID: 79955585486     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9372-z     Document Type: Article

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