Altered brain activation in ventral frontal-Striatal regions following a 16-week pharmacotherapy in unmedicated obsessive-Compulsive disorder

Journal of Korean Medical Science

Volumn 26, Issue 5, 2011, Pages 665-674

  Han, Ji Yeon ^a   Kang, Do Hyung ^b   Gu, Bon Mi ^a   Jung, Wi Hoon ^a   Choi, Jung Seok ^b   Choi, Chi Hoon ^c   Jang, Joon Hwan ^a,b   Kwon, Jun Soo ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c National Emergency Medical Center National Medical Center   (South Korea)

Author keywords

Cognitive flexibility; Drug therapy; Obsessive compulsive disorder; Task switching; Ventral frontal striatal region

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; BEHAVIOR; DRUG EFFECT; FEMALE; FRONTAL LOBE; HUMAN; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSESSIVE COMPULSIVE DISORDER; PARIETAL LOBE; PATHOPHYSIOLOGY;

ADULT; BASAL GANGLIA; BEHAVIORAL SYMPTOMS; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OBSESSIVE-COMPULSIVE DISORDER; PARIETAL LOBE;

EID: 79955583590     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2011.26.5.665     Document Type: Article

References (30)

1. Graybiel AM, Rauch SL. Toward a neurobiology of obsessive-compulsive disorder. Neuron 2000; 28: 343-7.
2. Menzies L, Chamberlain SR, Laird AR, Telen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofrontostriatal model revisited. Neurosci Biobehav Rev 2008; 32: 525-49.
3. Gu BM, Park JY, Kang DH, Lee SJ, Yoo SY, Jo HJ, Choi CH, Lee JM, Kwon JS. Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder. Brain 2008; 131: 155-64.
4. Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008; 321: 421-2.
5. Remijnse PL, Nielen MM, van Balkom AJ, Cath DC, van Oppen P, Uylings HB, Veltman DJ. Reduced orbitofrontalstriatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry 2006; 63: 1225-36.
6. Kwon JS, Jang JH, Choi JS, Kang DH. Neuroimaging in obsessive-compulsive disorder. Expert Rev Neurother 2009; 9: 255-69.
7. Mataix-Cols D, van den Heuvel OA. Common and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatr Clin North Am 2006; 29: 391-410.
8. van den Heuvel OA, Veltman DJ, Groenewegen HJ, Cath DC, van Balkom AJ, van Hartskamp J, Barkhoff F, van Dyck R. Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch Gen Psychiatry 2005; 62: 301-9.
9. Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 2000; 23: 563-86.
10. Lázaro L, Caldú X, Junqué C, Bargalló N, Andrés S, Morer A, Castro-Fornieles J. Cerebral activation in children and adolescents with obsessive-compulsive disorder before and after treatment: a functional MRI study. J Psychiatr Res 2008; 42: 1051-9.
11. Nabeyama M, Nakagawa A, Yoshiura T, Nakao T, Nakatani E, Togao O, Yoshizato C, Yoshioka K, Tomita M, Kanba S. Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement. Psychiatry Res 2008; 163: 236-47.
12. Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, Kudoh A, Tada K, Yoshioka K, Kawamoto M, Togao O, Kanba S. Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: a functional magnetic resonance imaging study. Biol Psychiatry 2005; 57: 901-10.
13. Hansen ES, Hasselbalch S, Law I, Bolwig TG. Te caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. Int J Neuropsychopharmacol 2002; 5: 1-10.
14. Kang DH, Kwon JS, Kim JJ, Youn T, Park HJ, Kim MS, Lee DS, Lee MC. Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 2003; 107: 291-7.
15. Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N, Ho MK, Huang SC, Wu HM, Baxter LR Jr. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatr y 2002; 59: 250-61.
16. Saxena S, Brody AL, Maidment KM, Dunkin JJ, Colgan M, Alborzian S, Phelps ME, Baxter LR Jr. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 1999; 21: 683-93.
17. Nielen MM, Den Boer JA. Neuropsychological performance of OCD patients before and after treatment with fluoxetine: evidence for persistent cognitive deficits. Psychol Med 2003; 33: 917-25.
18. Henry JD. A meta-analytic review of Wisconsin Card Sorting Test and verbal fluency performance in obsessive-compulsive disorder. Cogn Neuropsychiatry 2006; 11: 156-76.
19. Kim MS, Park SJ, Shin MS, Kwon JS. Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment. J Psychiatr Res 2002; 36: 257-65.
20. Roh KS, Shin MS, Kim MS, Ha TH, Shin YW, Lee KJ, Kwon JS. Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study. Psychiatr y Clin Neurosci 2005; 59: 539-45.
21. Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry 1999; 156: 1409-16.
22. Monsell S. Task switching. Trends Cogn Sci 2003; 7: 134-40.
23. Radua J, Mataix-Cols D. Voxelwise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br J Psychiatry 2009; 195: 393-402.
24. Ho Pian KL, van Megen HJ, Ramsey NF, Mandl R, van Rijk PP, Wynne HJ, Westenberg HG. Decreased thalamic blood flow in obsessive-compulsive disorder patients responding to fluvoxamine. Psychiatry Res 2005; 138: 89-97.
25. Yoo SY, Jang JH, Shin YW, Kim DJ, Park HJ, Moon WJ, Chung EC, Lee JM, Kim IY, Kim SI, Kwon JS. White matter abnormalities in drugnaive patients with obsessive-compulsive disorder: a difusion tensor study before and after citalopram treatment. Acta Psychiatr Scand 2007; 116: 211-9.
26. Kwon JS, Kim JJ, Lee DW, Lee JS, Lee DS, Kim MS, Lyoo IK, Cho MJ, Lee MC. Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. Psychiatry Res 2003; 122: 37-47.
27. Phillips ML, Ladouceur CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008; 13: 829, 833-57.
28. Zitterl W, Aigner M, Stompe T, Zitterl-Eglseer K, Gutierrez-Lobos K, Wenzel T, Zettinig G, Hornik K, Pirker W, Tau K. Changes in thalamushypothalamus serotonin transporter availability during clomipramine administration in patients with obsessive-compulsive disorder. Neuropsychopharmacology 2008; 33: 3126-34.
29. Sohn MH, Ursu S, Anderson JR, Stenger VA, Carter CS. Te role of pre-frontal cortex and posterior parietal cortex in task switching. Proc Natl Acad Sci USA 2000; 97: 13448-53.
30. Jang JH, Kwon JS, Jang DP, Moon WJ, Lee JM, Ha TH, Chung EC, Kim IY, Kim SI. A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drugnaive patients with obsessive-compulsive disorder. Am J Psychiatry 2006; 163: 1202-7.