Unraveling the response of plant cells to cytotoxic saponins: Role of metallothionein and nitric oxide

Plant Signaling and Behavior

Volumn 6, Issue 4, 2011, Pages 516-519

  Balestrazzi, Alma ^a   Macovei, Anca ^a   Tava, Aldo ^b   Avato, Pinarosa ^c   Raimondi, Elena ^a   Carbonera, Daniela ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Metallothionein; Nitric oxide; Plant cell; Plant saponins; Reactive oxygen species; Signal transduction pathway

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; METALLOTHIONEIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SAPONIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOLOGICAL MODEL; DRUG EFFECT; METABOLISM; PLANT; SIGNAL TRANSDUCTION;

INTERLEUKIN-6; METALLOTHIONEIN; MODELS, BIOLOGICAL; NF-KAPPA B; NITRIC OXIDE; PLANTS; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 79955578792     PISSN: 15592316     EISSN: 15592324     Source Type: Journal    
DOI: 10.4161/psb.6.4.14746     Document Type: Article

References (21)

1. Cobbet C, Goldsbrough P. Phytochelatins and metallothioneins:Roles in heavy metal detoxification and homeostasis. Annu Rev Plant Biol 2002; 53:159-82.
2. Balestrazzi A, Botti S, Zelasco S, Biondi S, Franchin C, Calligari P, et al. Expression of the PsMTA1 gene in white poplar engineered with the MAT system is associated to heavy metal tolerance and protec-tion against 8-hydroxy-2'-deoxyguanosine mediatedDNA damage. Plant Cell Rep 2009; 28:1179-92.
3. Zangger K, Oz G, Haslinger E, Kunert O, Armitage IM. Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: Potential roles at inflammatory sites. FASEB J 2001; 15:1303-5.
4. Liu SX, Fabisiak JP, Tyurin V, Borisenko GG, Pitt BR, Lazo JS, et al. Nitric oxide-dependent prooxidant and pro-apoptotic effect of HL-60 cells challenged with cupric nitrilo-triacetate. Biochem J 2001; 345:397-406.
5. Stamler JS, Lamas S, Fang FC. Nitrosylation: The prototypic redox-based signaling mechanisms. Cell 2001; 106:675-83.
6. Stitt MS, Wasserloos KJ, Tang X, Liu X, Pitt BR, St. Croix CM. Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein. Vasc Pharmacol 2006; 44:149-55.
7. Balestrazzi A, Macovei A, Testoni C, Raimondi E, Donà M, Carbonera D. Nitric oxide biosynthesis in white poplar (Populus alba L.) suspension cultures challenged with heavy metals. Plant Stress 2009; 1:1-6.
8. Macovei A, Ventura L, Donà M, Faè M, Balestrazzi A, Carbonera D. Effects of heavy metal treatments on metallothionein expression profiles in white poplar (Populus alba L.) cell suspension cultures. Analele Universitatii din Oradea-Fascicula Biologie 2010. Available at: http://www.bioresearch.ro/revistaen.html.
9. Francis G, Kerem Z, Makkar HPS, Becker K. The biological action of saponins in animal systems: A review. British J Nutr 2002; 88:587-605.
10. Tava A, Avato P. Chemical and biological activity of triterpene saponins of Medicago species. Nat Prod Commu 2006; 1:1159-80.
11. Podolak I, Galanty A, Sobolewska D. Saponins as cytotoxic agents: A review. Phytochem Rev 2010; 9:425-74.
12. Haridas V, Arntzen CJ, Gutterman JU. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factorκB by inhibiting both its nuclear localization and abil-ity to bind DNA. Proc Natl Acad Sci USA 2001; 98:11557-62.
13. Nakaya Y, Mawatari K, Takahashi A, Harada N, Hata A, Yasui S. The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through P13k/Akt and nitric oxide pathways. J Med Inv 2007; 54:381-4.
14. Itoh N, Morishita Y, Tanaka T, Muto N, Kobayashi M, Kitagawa I, et al. Metallothionein induction and hepatoprotection by echinoside A and sakurasosaponin. Phytoter Res 1997; 11:132-5.
15. Kim JY, Choi CY, Jeong HG. Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin. Planta Med 2005; 71:743-7.
16. Balestrazzi A, Agoni V, Tava A, Avato P, Biazzi E, Raimondi E, et al. Cell death induction and nitric oxide biosynthesis in white poplar (Populus alba) suspension cultures exposed to alfalfa saponins. Physiol Plant 2011; 1:227-38; DOI: 10.1111/j.13993054.2010.01436.x.
17. Wang Y, Che CM, Chlu JF, He QY. Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria disfunction: A proteomicbased study. J Prot Res 2007; 6:4703-10.
18. Ito SI, Ihara T, Tamura H, Tanaka S, Ikeda T, Kajihara H, et al. α-tomatine, the major saponin in tomato, induces programmed cell death mediated by reactive oxygen species in the fungal pathogen Fusarium oxysperum. FEBS Lett 2000; 581:3217-22.
19. Castaneda CA, Cortes-Funes H, Gomez HL, Ciruelos EM. The phosphatidyl inositol 3-kinase/ AKT signaling pathway in breast cancer. Cancer Metastasis Rev 2010; 29:751-9.
20. Meijer HJG, Munnik T. Phospholipid-based signaling in plants. Annu Rev Plant Biol 2003; 54:265-306.
21. Leshem Y, Seri L, Levine A. Induction of phospha-tidylinositol-3-kinase-mediated endocytosis by salt stress leads to intracellular production of reactive oxygen species and salt tolerance. Plant J 2007; 51:185-97.