Synthesis and characterization of new types of halogenated and alkylated imidazolidineiminothiones and a comparative study of their antitumor, antibacterial, and antifungal activities

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2280-2289

  Moussa, Ziad ^a   El Sharief, Marwa A M Sh ^b   El Sharief, Ahmed M Sh ^c  

^a TAIBAH UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c Al Azhar University   (Egypt)

Author keywords

Alkylated imidazolidineiminothiones; Antifungal; Antimicrobial; Antitumor; Halogenated imidazolidineiminothiones; N Arylcyanothioformanilides

Indexed keywords

1 (2,4 DIMETHOXYPHENYL) 4 IMINO 3 (4 (METHYLTHIO)PHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (2,4 DIMETHOXYPHENYL) 4 IMINO 3 (4 METHOXYPHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (2,4 DIMETHOXYPHENYL) 4 IMINO 5 THIOXO 3 4 TOLYLIMIDAZOLIDIN 2 ONE; 1 (4 BROMOPHENYL) 4 IMINO 3 (4 (METHYLTHIO)PHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (4 BROMOPHENYL) 4 IMINO 3 (4 METHOXYPHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (4 BROMOPHENYL) 4 IMINO 5 THIOXO 3 4 TOLYLIMIDAZOLIDIN 2 ONE; 1 (4 CHLOROPHENYL) 4 IMINO 3 (4 (METHYLTHIO)PHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (4 CHLOROPHENYL) 4 IMINO 3 (4 METHOXYPHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 1 (4 CHLOROPHENYL) 4 IMINO 5 THIOXO 3 4 TOLYLIMIDAZOLIDIN 2 ONE; 3 BENZYL 1 (4 BROMOPHENYL) 4 IMINO 5 THIOXOIMIDAZOLIDIN 2 ONE; 3 BENZYL 1 (4 CHLOROPHENYL) 4 IMINO 5 THIOXOIMIDAZOLIDIN 2 ONE; 3 BENZYL 4 IMINO 1 (4 IODOPHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 3 BENZYL 4 IMINO 1 PHENYL 5 THIOXOIMIDAZOLIDIN 2 ONE; 4 IMINO 1 (4 IODOPHENYL) 3 (4 (METHYLTHIO)PHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 4 IMINO 1 (4 IODOPHENYL) 3 (4 METHOXYPHENYL) 5 THIOXOIMIDAZOLIDIN 2 ONE; 4 IMINO 1 (4 IODOPHENYL) 5 THIOXO 3 4 TOLYLIMIDAZOLIDIN 2 ONE; 4 IMINO 1 PHENYL 5 THIOXO 3 4 TOLYLIMIDAZOLIDIN 2 ONE; 4 IMINO 3 (4 (METHYLTHIO)PHENYL) 1 PHENYL 5 THIOXOIMIDAZOLIDIN 2 ONE; 4 IMINO 3 (4 METHOXYPHENYL) 1 PHENYL 5 THIOXOIMIDAZOLIDIN 2 ONE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; IMIDAZOLIDINEIMINOTHIONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; BACILLUS SUBTILIS; CANDIDA ALBICANS; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL VIABILITY; COMPARATIVE STUDY; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; ESCHERICHIA COLI; FEMALE; HELA CELL; HEP 2 CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FUNGI; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES;

EID: 79955576860     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.009     Document Type: Article

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