MMP-13 selective α-sulfone hydroxamates: A survey of P1′ heterocyclic amide isosteres

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2820-2822

  Barta, Thomas E ^a   Becker, Daniel P ^a   Bedell, Louis J ^a   Easton, Alan M ^a   Hockerman, Susan L ^a   Kiefer, James ^a   Munie, Grace E ^a   Mathis, Karl J ^a   Li, Madeleine H ^a   Rico, Joseph G ^a   Villamil, Clara I ^a   Williams, Jennifer M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; COLLAGENASE 3; GELATINASE A; HETEROCYCLIC COMPOUND; HYDROXAMIC ACID DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; SULFONE DERIVATIVE; TETRAZOLE DERIVATIVE;

ARTICLE; DRUG HALF LIFE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY;

AMIDES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 13; MODELS, MOLECULAR; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFONES;

RATTUS;

EID: 79955564354     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.099     Document Type: Article

References (8)

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5. For a conceptually related series, see: J. Wu, T.S. Rush, R. Hotchandani, X. Du, M. Geck, E. Collins, Z.B. Xu, J. Skotnicki, J.I. Levin, and F.E. Lovering Bioorg. Med. Chem. Lett. 15 2005 4105
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8. Coordinates have been deposited in the protein data bank (accession code 3O2X ). Crystallographic conditions are detailed in the Supplementary data.