Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model

PLoS Computational Biology

Volumn 7, Issue 4, 2011, Pages

  Parameswaran, Harikrishnan ^a   Majumdar, Arnab ^a   Suki, Béla ^a  

^a Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; COLLAGEN; COMPUTATION THEORY; COMPUTATIONAL METHODS; MUSCULOSKELETAL SYSTEM; PRINCIPAL COMPONENT ANALYSIS; STIFFNESS; TISSUE;

CELL VOLUME; COMPUTATIONAL MODELLING; CONNECTIVE TISSUE DISEASE; ELASTIC RECOIL; FORCE-BASED; PROGRESSIVE DESTRUCTION; PULMONARY EMPHYSEMA; SPATIAL PATTERNS; TISSUE DESTRUCTION; TISSUE STRUCTURE;

ELASTIC MODULI;

ARTICLE; CELL VOLUME; COMPUTER SIMULATION; CONTROLLED STUDY; FUNCTIONAL MORPHOLOGY; LINEAR SYSTEM; LUNG ALVEOLITIS; LUNG ALVEOLUS WALL; LUNG COMPLIANCE; LUNG EMPHYSEMA; LUNG INJURY; LUNG STRUCTURE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MICROSCOPE IMAGE; NONLINEAR SYSTEM; PROCESS DEVELOPMENT; RIGIDITY; THREE DIMENSIONAL IMAGING; YOUNG MODULUS; ALGORITHM; BIOLOGICAL MODEL; BIOLOGY; ELASTICITY; EMPHYSEMA; HUMAN; LUNG; LUNG ALVEOLUS; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY; STATISTICAL MODEL; THEORETICAL MODEL;

ALGORITHMS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ELASTICITY; EMPHYSEMA; HUMANS; IMAGING, THREE-DIMENSIONAL; LUNG; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MODELS, THEORETICAL; PRINCIPAL COMPONENT ANALYSIS; PULMONARY ALVEOLI; REPRODUCIBILITY OF RESULTS;

EID: 79955559392     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001125     Document Type: Article

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