AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 5, 2011, Pages

  Darrabie, Marcus D ^a   Arciniegas, Antonio Jose Luis ^a   Mishra, Rajashree ^a   Bowles, Dawn E ^a   Jacobs, Danny O ^a   Santacruz, Lucia ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenosine 5' monophosphate activated protein kinase; Cardiac energy metabolism; Cardiac failure; Myocardial creatine content

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; CREATINE; CREATINE PHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; HEART CELL CULTURE; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOTTING, WESTERN; CELLS, CULTURED; CREATINE; CULTURE MEDIA; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA, COMPLEMENTARY; KINETICS; MEMBRANE PROTEINS; MICE; MYOCYTES, CARDIAC; PLASMIDS; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RIBONUCLEOTIDES; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 79955559069     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00554.2010     Document Type: Article

References (25)

1. Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart: role during health and disease. Circ Res 100: 474-488, 2007.
2. Arent S, Pellegrino J, Williams C, Difabio D, Greenwood J. Nutritional supplementation, performance, and oxidative stress in college soccer players. J Strength Cond Res 24: 1117-1124, 2010.
3. Boehm E, Chan S, Monfared M, Wallimann T, Clarke K, Neubauer S. Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab 284: E399-E406, 2003.
4. Bursac N, Papadaki M, Cohen RJ, Schoen FJ, Eisenberg SR, Carrier R, Vunjak-Novakovic G, Freed LE. Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies. Am J Physiol Heart Circ Physiol 277: H433-H444, 1999.
5. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ Jr. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 95: 2979-2984, 1998.
6. Daniels GM, Amara SG. Selective labeling of neurotransmitter transporters at the cell surface. Methods Enzymol 296: 307-318, 1998.
7. Hardie DG. AMPK and Raptor: matching cell growth to energy supply. Mol Cell 30: 263-265, 2008.
8. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase- development of the energy sensor concept. J Physiol 574: 7-15, 2006.
9. Ingwall JS, Weiss RG. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95: 135-145, 2004.
10. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol 299: F167-F177, 2010.
11. Loike JD, Zalutsky DL, Kaback E, Miranda AF, Silverstein SC. Extracellular creatine regulates creatine transport in rat and human muscle cells. Proc Natl Acad Sci USA 85: 807-811, 1988.
12. Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 451: 578-582, 2008.
13. Nash SR, Giros B, Kingsmore SF, Rochelle JM, Suter ST, Gregor P, Seldin MF, Caron MG. Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Receptors Channels 2: 165-174, 1994.
14. Neubauer S. The failing heart-an engine out of fuel. N Engl J Med 356: 1140-1151, 2007.
15. Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K. Myocardial phosphocreatine- to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96: 2190-2196, 1997.
16. Persky AM, Müller M, Derendorf H, Grant M, Brazeau GA, Hochhaus G. Single- and multiple-dose pharmacokinetics of oral creatine. J Clin Pharmacol 43: 29-37, 2003.
17. Russell RR 3rd, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 114: 495-503, 2004.
18. Shojaiefard M, Christie D, Lang F. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. Biochem Biophys Res Commun 334: 742-746, 2005.
19. Starling RC, Hammer DF, Altschuld RA. Human myocardial ATP content and in vivo contractile function. Mol Cell Biochem 180: 171-177, 1998.
20. Strutz-Seebohm N, Shojaiefard M, Christie D, Tavare J, Seebohm G, Lang F. PIKfyve in the SGK1 mediated regulation of the creatine transporter SLC6A8. Cell Physiol Biochem 20: 729-734, 2007.
21. Swynghedauw B, Delcayre C, Samuel JL, Mebazaa A, Cohen-Solal A. Molecular mechanisms in evolutionary cardiology failure. Ann NY Acad Sci 1188: 58-67, 2010.
22. White SM, Constantin PE, Claycomb WC. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am J Physiol Heart Circ Physiol 286: H823-H829, 2004.
23. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 80: 1107-1213, 2000.
24. Yasuhara M, Fujita S, Arisue K, Kohda K, Hayashi C. A new enzymatic method to determine creatine. Clin Chim Acta 122: 181-188, 1982.
25. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174, 2001.