Synthesis and antitumor activity of 5-[1-(3-(dimethylamino)propyl)-5- halogenated-2-oxoindolin-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3- carboxamides

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 3062-3065

  Lv, Kai ^a,b   Wang, Li Li ^a   Liu, Ming Liang ^b   Zhou, Xin Bo ^a   Fan, Shi Yong ^a   Liu, Hong Ying ^a   Zheng, Zhi Bing ^a   Li, Song ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Antitumor activity; Indolin 2 ones; Synthesis

Indexed keywords

1 [3 (DIMETHYLAMINO)PROPYL]INDOLIN 2 ONE DERIVATIVE; 5 [1 (3 (DIMETHYLAMINO)PROPYL) 5 HALOGENATED 2 OXOINDOLINYLIDENEMETHYL] 2,4 DIMETHYL 1H PYRROLE 3 CARBOXAMIDE; AMIDE; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; SUNITINIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; HALOGENS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRROLES;

EID: 79955556213     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.031     Document Type: Article

References (20)

1. K. Naparat, B. Chantana, S. Kingkan, U. Maleeruk, T. Satoshi, S. Hiroaki, S. Ikuo, A. Isabelle, S.G. David, and V. Opa Bioorg. Med. Chem. Lett. 19 2009 745
2. L. Yisheng, M. Lin, H. Wenxing, Y. Xing, Z. Yihua, J. Hui, and T. Jide Bioorg. Med. Chem. Lett. 20 2010 7349
3. T.A. Fong, L.K. Shawver, L. Sun, C. Tang, H. App, T.J. Powell, Y.H. Kim, R. Schreck, X. Wang, W. Risau, A. Ullrich, K.P. Hirth, and G. McMahon Cancer Res. 59 1999 99
4. R.M. Shaheen, D.W. Davis, W. Liu, B.K. Zebrowski, M.R. Wilson, C.D. Bucana, D.J. McConkey, G. McMahon, and L.M. Ellis Cancer Res. 59 1999 5412
5. R. Longo, R. Sarmiento, M. Fanelli, B. Capaccetti, D. Gattuso, and G. Gasparini Angiogenesis 5 2002 237
6. B.C. Kuenen, L. Rosen, E.F. Smit, M.R. Parson, M. Levi, R. Ruijter, H. Huisman, M.A. Kedde, P. Noordhuis, W.J. Vandervijgh, G.J. Peters, G.F. Cropp, P. Scigalla, K. Hoekman, H.M. Pinedo, and G. Giaccone J. Clin. Oncol. 20 2002 1657
7. L. Sun, C. Liang, S. Shirazian, Y. Zhou, T. Miller, J. Cui, J.Y. Fukuda, J.Y. Chu, A. Nematalla, X. Wang, H. Chen, A. Sistla, T.C. Luu, F. Tang, J. Wei, and C. Tang J. Med. Chem. 46 2003 1116
8. A.M. O'Farrell, T.J. Abrams, H.A. Yuen, T.J. Ngai, S.G. Louie, K.W. Yee, L.M. Wong, W. Hong, L.B. Lee, A. Town, B.D. Smolich, W.C. Manning, L.J. Murray, M.C. Heinrich, and J.M. Cherrington Blood 101 2003 3597
9. E. Young, L. Miele, K.B. Tucker, M. Huang, J. Wells, and J.W. Gu Cancer Biol. Ther. 10 2010 703
10. T. Ikezoe, C. Nishioka, T. Tasaka, Y. Yang, N. Komatsu, K. Togitani, H.P. Koeffler, and H. Taguchi Mol. Cancer Ther. 5 2006 2522
11. O. Lyros, A. Mueller, F. Heidel, C.C. Schimanski, I. Gockel, P.R. Galle, H. Lang, and M. Moehler Int. J. Cancer 127 2010 1197
12. Hui, E. P.; Lui, V. W.; Wong, C. S.; Ma, B. B.; Lau, C. P.; Cheung, C. S.; Ho, K.; Cheng, S. H.; Ng, M. H.; Chan, A. T. Invest. New Drugs 2010, doi: 10.1007/s10637-010-9451-1
13. A. Morabito, E. De Maio, M. Di Maio, N. Normanno, and F. Perrone Oncologist 11 2006 753
14. L.L. Wang, J.J. Li, Z.B. Zheng, H.Y. Liu, G.J. Du, and S. Li Eur. J. Pharmacol. 502 2004 1
15. H.Y. Lu, C. Lin, Z. Zheng, S. Li, S. Guo, X. Zhang, M. Fu, X. Liang, and M. Wu J. Pharmacol. Sci. 97 2005 533
16. H.Y. Lu, C. Lin, S. Li, Z.B. Zheng, X.Y. Zhang, L.S. Zhang, G.Z. Xu, S.X. Guo, M. Wu, and M. Fu Chin. J. Pharmacol. Toxicol. 17 2003 401
17. S.S. David J. Chem. Edu. 70 1993 332
18. +.
19. L.M. Green, J.L. Reade, and C.F. Ware J. Immunol. Methods 70 1984 257
20. K. Lv, Y.M. Du, D.M. Zhao, Z.B. Zheng, and S. Li Chin. J. Med. Chem. 19 2009 116