Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome

Arthritis and Rheumatism

Volumn 63, Issue 5, 2011, Pages 1426-1434

  Park, Kyungpyo ^a   Haberberger, Rainer V ^b   Gordon, Tom P ^b   Jackson, Michael W ^b  

^a Seoul National University   (South Korea)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; MUSCARINIC M3 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CASE REPORT; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; GASTROINTESTINAL MOTILITY; HUMAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SJOEGREN SYNDROME; SMOOTH MUSCLE CONTRACTION;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AUTOANTIBODIES; CARBACHOL; CHOLINERGIC AGONISTS; CISPLATIN; GASTROINTESTINAL MOTILITY; HUMANS; IFOSFAMIDE; MALE; MICE; MICE, KNOCKOUT; MITOMYCIN; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTOR, MUSCARINIC M3; SJOGREN'S SYNDROME; SYNAPTIC TRANSMISSION;

EID: 79955555988     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30282     Document Type: Article

References (44)

1. Mandl T, Hammar O, Theander E, Wollmer P, Ohlsson B,. Autonomic nervous dysfunction development in patients with primary Sjögren's syndrome: a follow-up study. Rheumatology (Oxford) 2010; 49: 1101-6.
2. Griffin JW, Cornblath DR, Alexander E, Campbell J, Low PA, Bird S, et al. Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren's syndrome. Ann Neurol 1990; 27: 304-15. (Pubitemid 20122383)
3. Cai FZ, Lester S, Lu T, Keen H, Boundy K, Proudman SM, et al. Mild autonomic dysfunction in primary Sjögren's syndrome: a controlled study. Arthritis Res Ther 2008; 10: R31.
4. Papiris SA, Tsonis IA, Moutsopoulos HM,. Sjögren's syndrome. Semin Respir Crit Care Med 2007; 28: 459-71.
5. Turk T, Pirildar T, Tunc E, Bor S, Doganavsargil E,. Manometric assessment of esophageal motility in patients with primary Sjögren's syndrome. Rheumatol Int 2005; 25: 246-9. (Pubitemid 40767826)
6. Rosztoczy A, Kovacs L, Wittmann T, Lonovics J, Pokorny G,. Manometric assessment of impaired esophageal motor function in primary Sjögren's syndrome. Clin Exp Rheumatol 2001; 19: 147-52. (Pubitemid 32372450)
7. Kovacs L, Papos M, Takacs R, Roka R, Csenke Z, Kovacs A, et al. Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjögren's syndrome. Clin Exp Rheumatol 2003; 21: 697-703. (Pubitemid 38008751)
8. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, et al. Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjögren's syndrome patients. Rheumatology (Oxford) 2008; 47: 828-33. (Pubitemid 351796368)
9. Dawson LJ, Allison HE, Stanbury J, Fitzgerald D, Smith PM,. Putative anti-muscarinic antibodies cannot be detected in patients with primary Sjögren's syndrome using conventional immunological approaches. Rheumatology (Oxford) 2004; 43: 1488-95. (Pubitemid 39642571)
10. Li J, Ha YM, Ku NY, Choi SY, Lee SJ, Oh SB, et al. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome. Lab Invest 2004; 84: 1430-8. (Pubitemid 39482160)
11. Waterman SA, Gordon TP, Rischmueller M,. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. Arthritis Rheum 2000; 43: 1647-54. (Pubitemid 30452487)
12. Goldblatt F, Gordon TP, Waterman SA,. Antibody-mediated gastrointestinal dysmotility in scleroderma. Gastroenterology 2002; 123: 1144-50.
13. Wang F, Jackson MW, Maughan V, Cavill D, Smith AJ, Waterman SA, et al. Passive transfer of Sjögren's syndrome IgG produces the pathophysiology of overactive bladder. Arthritis Rheum 2004; 50: 3637-45. (Pubitemid 39488691)
14. Matsui M, Motomura D, Karasawa H, Fujikawa T, Jiang J, Komiya Y, et al. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A 2000; 97: 9579-84. (Pubitemid 30650818)
15. Stengel PW, Yamada M, Wess J, Cohen ML,. M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea. Am J Physiol Regul Integr Comp Physiol 2002; 282: R1443-9. (Pubitemid 34664532)
16. Wess J, Eglen RM, Gautam D,. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 2007; 6: 721-33. (Pubitemid 47342315)
17. Takeuchi T, Tanaka K, Nakajima H, Matsui M, Azuma YT,. M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained with muscarinic-receptor knockout mouse. Am J Physiol Gastrointest Liver Physiol 2007; 292: G154-64. (Pubitemid 46090260)
18. Kitazawa T, Hashiba K, Cao J, Unno T, Komori S, Yamada M, et al. Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice. Eur J Pharmacol 2007; 554: 212-22. (Pubitemid 44879413)
19. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al, and the European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-8. (Pubitemid 34539104)
20. Jackson MW, Reed JH, Smith AJ, Gordon TP,. An autoantibody in narcolepsy disrupts colonic migrating motor complexes. J Neurosci 2008; 28: 13303-9.
21. Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, et al. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 1999; 96: 1692-7. (Pubitemid 29098513)
22. Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, et al. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 1999; 96: 10483-8. (Pubitemid 29422585)
23. Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, et al. Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron 2002; 33: 615-24. (Pubitemid 34188436)
24. Schemann M,. Control of gastrointestinal motility by the "gut brain": the enteric nervous system. J Pediatr Gastroenterol Nutr 2005; 41 Suppl 1: S4-6. (Pubitemid 41291429)
25. Powell AK, O'Brien SD, Fida R, Bywater RA,. Neural integrity is essential for the propagation of colonic migrating motor complexes in the mouse. Neurogastroenterol Motil 2002; 14: 495-504. (Pubitemid 35216332)
26. Dickson EJ, Heredia DJ, McCann CJ, Hennig GW, Smith TK,. The mechanisms underlying the generation of the colonic migrating motor complex in both wild-type and nNOS knockout mice. Am J Physiol Gastrointest Liver Physiol 2010; 298: G222-32.
27. Jackson MW, Gordon TP, Waterman SA,. Disruption of intestinal motility by a calcium channel-stimulating autoantibody in type 1 diabetes. Gastroenterology 2004; 126: 819-28. (Pubitemid 38298330)
28. Brierley SM, Nichols K, Grasby DJ, Waterman SA,. Neural mechanisms underlying migrating motor complex formation in mouse isolated colon. Br J Pharmacol 2001; 132: 507-17. (Pubitemid 32142365)
29. Cavill D, Waterman SA, Gordon TP,. Antiidiotypic antibodies neutralize autoantibodies that inhibit cholinergic neurotransmission. Arthritis Rheum 2003; 48: 3597-602. (Pubitemid 37531927)
30. Humphreys-Beher MG, Brayer J, Yamachika S, Peck AB, Jonsson R,. An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression. Scand J Immunol 1999; 49: 7-10. (Pubitemid 29052430)
31. Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN, Smith PM,. Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum 2006; 54: 1165-73. (Pubitemid 43672929)
32. El-Sharkawy TY, Markus H, Diamant NE,. Neural control of the intestinal migrating myoelectric complex: a pharmacological analysis. Can J Physiol Pharmacol 1982; 60: 794-804. (Pubitemid 12095360)
33. Barocelli E, Ballabeni V, Chiavarini M, Caretta A, Molina E, Impicciatore M,. Regional differences in motor responsiveness to antimuscarinic drugs in rabbit isolated small and large intestine. Pharmacol Res 1995; 31: 43-8.
34. De Ponti F, Einaudi A, Cosentino M, D'Angelo L, Lecchini S, Frigo GM, et al. Differential effects of antimuscarinic agents on intestinal motility in the conscious dog. J Pharmacol Exp Ther 1993; 264: 789-94. (Pubitemid 24283542)
35. Fida R, Lyster DJ, Bywater RA, Taylor GS,. Colonic migrating motor complexes (CMMCs) in the isolated mouse colon. Neurogastroenterol Motil 1997; 9: 99-107. (Pubitemid 27260806)
36. Leppilahti M, Tammela TL, Huhtala H, Kiilholma P, Leppilahti K, Auvinen A,. Interstitial cystitis-like urinary symptoms among patients with Sjögren's syndrome: a population-based study in Finland. Am J Med 2003; 115: 62-5. (Pubitemid 36831124)
37. Walker J, Gordon T, Lester S, Downie-Doyle S, McEvoy D, Pile K, et al. Increased severity of lower urinary tract symptoms and daytime somnolence in primary Sjögren's syndrome. J Rheumatol 2003; 30: 2406-12. (Pubitemid 37413901)
38. Drachman DB,. Autonomic "myasthenia": the case for an autoimmune pathogenesis. J Clin Invest 2003; 111: 797-9. (Pubitemid 37074952)
39. Bacman SR, Berra A, Sterin-Borda L, Borda ES,. Human primary Sjögren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors. Curr Eye Res 1998; 17: 1135-42. (Pubitemid 28562895)
40. Bacman S, Berra A, Sterin-Borda L, Borda E,. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren's syndrome. Invest Ophthalmol Vis Sci 2001; 42: 321-7. (Pubitemid 32121458)
41. Schegg V, Vogel M, Didichenko S, Stadler MB, Beleznay Z, Gadola S, et al. Evidence that anti-muscarinic antibodies in Sjögren's syndrome recognise both M3R and M1R. Biologicals 2008; 36: 213-22.
42. Gao J, Cha S, Jonsson R, Opalko J, Peck AB,. Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum 2004; 50: 2615-21. (Pubitemid 39062723)
43. Perez Leiros C, Sterin-Borda L, Hubscher O, Arana R, Borda ES,. Activation of nitric oxide signaling through muscarinic receptors in submandibular glands by primary Sjögren syndrome antibodies. Clin Immunol 1999; 90: 190-5. (Pubitemid 29162164)
44. Watson EL, Abel PW, DiJulio D, Zeng W, Makoid M, Jacobson KL, et al. Identification of muscarinic receptor subtypes in mouse parotid gland. Am J Physiol 1996; 271: C905-13.