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Volumn 55, Issue 5, 2011, Pages 2004-2010

Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; HEMAGGLUTININ; OSELTAMIVIR; SIALIDASE; VALINE; ZANAMIVIR;

EID: 79955546685     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01773-10     Document Type: Article
Times cited : (44)

References (53)
  • 1
    • 33845637926 scopus 로고    scopus 로고
    • Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds
    • Abed, Y., M. Baz, and G. Boivin. 2006. Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds. Antivir. Ther. 11:971-976.
    • (2006) Antivir. Ther. , vol.11 , pp. 971-976
    • Abed, Y.1    Baz, M.2    Boivin, G.3
  • 2
    • 67949124553 scopus 로고    scopus 로고
    • Characterizing loop dynamics and ligand recognition in human- and avian-type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations
    • Amaro, R. E., X. Cheng, I. Ivanov, D. Xu, and J. A. McCammon. 2009. Characterizing loop dynamics and ligand recognition in human- and avian-type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations. J. Am. Chem. Soc. 131:4702-4709.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 4702-4709
    • Amaro, R.E.1    Cheng, X.2    Ivanov, I.3    Xu, D.4    McCammon, J.A.5
  • 4
    • 70849113337 scopus 로고    scopus 로고
    • Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium
    • Ayora-Talavera, G., et al. 2009. Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. PLoS One 4:e7836.
    • (2009) PLoS One , vol.4
    • Ayora-Talavera, G.1
  • 5
    • 77949524294 scopus 로고    scopus 로고
    • Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic
    • Boltz, D. A., et al. 2009. Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic. J. Gen. Virol. 91:949-959.
    • (2009) J. Gen. Virol. , vol.91 , pp. 949-959
    • Boltz, D.A.1
  • 6
    • 70349976560 scopus 로고    scopus 로고
    • Molecular epidemiology of clade 1 influenza A viruses (H5N1), Southern Indochina Peninsula, 2004-2007
    • Buchy, P., et al. 2009. Molecular epidemiology of clade 1 influenza A viruses (H5N1), Southern Indochina Peninsula, 2004-2007. Emerg. Infect. Dis. 15:1641-1644.
    • (2009) Emerg. Infect. Dis. , vol.15 , pp. 1641-1644
    • Buchy, P.1
  • 7
    • 34250617533 scopus 로고    scopus 로고
    • Influenza A/H5N1 virus infection in humans in Cambodia
    • Buchy, P., et al. 2007. Influenza A/H5N1 virus infection in humans in Cambodia. J. Clin. Virol. 39:164-168.
    • (2007) J. Clin. Virol. , vol.39 , pp. 164-168
    • Buchy, P.1
  • 8
    • 0034194390 scopus 로고    scopus 로고
    • Development of a sensitive chemiluminescent neuraminidase assay for the determination of influenza virus susceptibility to zanamivir
    • Buxton, R. C., et al. 2000. Development of a sensitive chemiluminescent neuraminidase assay for the determination of influenza virus susceptibility to zanamivir. Anal. Biochem. 280:291-300.
    • (2000) Anal. Biochem. , vol.280 , pp. 291-300
    • Buxton, R.C.1
  • 9
    • 77951622123 scopus 로고    scopus 로고
    • Seroprevalence of anti-H5 antibody in rural Cambodia, 2007
    • Cavailler, P., et al. 2010. Seroprevalence of anti-H5 antibody in rural Cambodia, 2007. J. Clin. Virol. 48:123-126.
    • (2010) J. Clin. Virol. , vol.48 , pp. 123-126
    • Cavailler, P.1
  • 10
    • 44949093451 scopus 로고    scopus 로고
    • Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses
    • Chen, L. M., C. T. Davis, H. Zhou, N. J. Cox, and R. O. Donis. 2008. Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses. PLoS Pathog. 4:e1000072.
    • (2008) PLoS Pathog , vol.4
    • Chen, L.M.1    Davis, C.T.2    Zhou, H.3    Cox, N.J.4    Donis, R.O.5
  • 11
    • 0027988832 scopus 로고
    • Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates
    • Connor, R. J., Y. Kawaoka, R. G. Webster, and J. C. Paulson. 1994. Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology 205:17-23.
    • (1994) Virology , vol.205 , pp. 17-23
    • Connor, R.J.1    Kawaoka, Y.2    Webster, R.G.3    Paulson, J.C.4
  • 12
    • 0027302926 scopus 로고
    • Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity
    • Couceiro, J. N., J. C. Paulson, and L. G. Baum. 1993. Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity. Virus Res. 29:155-165.
    • (1993) Virus Res , vol.29 , pp. 155-165
    • Couceiro, J.N.1    Paulson, J.C.2    Baum, L.G.3
  • 13
    • 30044433592 scopus 로고    scopus 로고
    • Evolution of the receptor binding phenotype of influenza A (H5) viruses
    • DOI 10.1016/j.virol.2005.08.035, PII S0042682205005313
    • Gambaryan, A., et al. 2006. Evolution of the receptor binding phenotype of influenza A (H5) viruses. Virology 344:432-438. (Pubitemid 43049630)
    • (2006) Virology , vol.344 , Issue.2 , pp. 432-438
    • Gambaryan, A.1    Tuzikov, A.2    Pazynina, G.3    Bovin, N.4    Balish, A.5    Klimov, A.6
  • 14
    • 0035865919 scopus 로고    scopus 로고
    • Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir
    • Gubareva, L. V., L. Kaiser, M. N. Matrosovich, Y. Soo-Hoo, and F. G. Hayden. 2001. Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J. Infect. Dis. 183:523-531.
    • (2001) J. Infect. Dis. , vol.183 , pp. 523-531
    • Gubareva, L.V.1    Kaiser, L.2    Matrosovich, M.N.3    Soo-Hoo, Y.4    Hayden, F.G.5
  • 15
    • 0036027825 scopus 로고    scopus 로고
    • Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay
    • Gubareva, L. V., R. G. Webster, and F. G. Hayden. 2002. Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay. Antiviral Res. 53:47-61.
    • (2002) Antiviral Res. , vol.53 , pp. 47-61
    • Gubareva, L.V.1    Webster, R.G.2    Hayden, F.G.3
  • 16
    • 0036228067 scopus 로고    scopus 로고
    • Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets
    • DOI 10.1016/S0166-3542(01)00214-5, PII S0166354201002145
    • Herlocher, M. L., et al. 2002. Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets. Antiviral Res. 54:99-111. (Pubitemid 34327688)
    • (2002) Antiviral Research , vol.54 , Issue.2 , pp. 99-111
    • Herlocher, M.L.1    Carr, J.2    Ives, J.3    Elias, S.4    Truscon, R.5    Roberts, N.6    Monto, A.S.7
  • 18
    • 70349313487 scopus 로고    scopus 로고
    • In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses
    • Hurt, A. C., J. K. Holien, and I. G. Barr. 2009. In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses. Antimicrob. Agents Chemother. 53:4433-4440.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4433-4440
    • Hurt, A.C.1    Holien, J.K.2    Barr, I.G.3
  • 19
    • 70349728568 scopus 로고    scopus 로고
    • Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
    • Hurt, A. C., J. K. Holien, M. Parker, A. Kelso, and I. G. Barr. 2009. Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. J. Virol. 83:10366-10373.
    • (2009) J. Virol. , vol.83 , pp. 10366-10373
    • Hurt, A.C.1    Holien, J.K.2    Parker, M.3    Kelso, A.4    Barr, I.G.5
  • 20
    • 77955842998 scopus 로고    scopus 로고
    • Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model
    • Hurt, A. C., S. Lowther, D. Middleton, and I. G. Barr. 2010. Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model. Antiviral Res. 87:361-366.
    • (2010) Antiviral Res. , vol.87 , pp. 361-366
    • Hurt, A.C.1    Lowther, S.2    Middleton, D.3    Barr, I.G.4
  • 21
    • 33847038372 scopus 로고    scopus 로고
    • Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes
    • Hurt, A. C., et al. 2007. Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes. Antiviral Res. 73:228-231.
    • (2007) Antiviral Res. , vol.73 , pp. 228-231
    • Hurt, A.C.1
  • 22
    • 55849102109 scopus 로고    scopus 로고
    • Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice
    • Ilyushina, N. A., et al. 2008. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob. Agents Chemother. 52:3889-3897.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 3889-3897
    • Ilyushina, N.A.1
  • 23
    • 77954079771 scopus 로고    scopus 로고
    • Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/turkey/15/06 (H5N1) influenza virus in ferrets
    • Ilyushina, N. A., J. P. Seiler, J. E. Rehg, R. G. Webster, and E. A. Govorkova. 2010. Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/turkey/15/06 (H5N1) influenza virus in ferrets. PLoS Pathog. 6:e1000933.
    • (2010) PLoS Pathog. , vol.6
    • Ilyushina, N.A.1    Seiler, J.P.2    Rehg, J.E.3    Webster, R.G.4    Govorkova, E.A.5
  • 24
    • 0031579234 scopus 로고    scopus 로고
    • Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species
    • DOI 10.1006/viro.1996.8323
    • Ito, T., et al. 1997. Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species. Virology 227:493-499. (Pubitemid 27241043)
    • (1997) Virology , vol.227 , Issue.2 , pp. 493-499
    • Ito, T.1    Suzuki, Y.2    Mitnaul, L.3    Vines, A.4    Kida, H.5    Kawaoka, Y.6
  • 25
    • 14744304629 scopus 로고    scopus 로고
    • Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations
    • Jackson, D., W. Barclay, and T. Zurcher. 2005. Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations. J. Antimicrob. Chemother. 55:162-169.
    • (2005) J. Antimicrob. Chemother. , vol.55 , pp. 162-169
    • Jackson, D.1    Barclay, W.2    Zurcher, T.3
  • 26
    • 57049187243 scopus 로고    scopus 로고
    • The potential impact of neuraminidase inhibitor resistant influenza
    • Lackenby, A., C. Thompson, and J. Democratis. 2008. The potential impact of neuraminidase inhibitor resistant influenza. Curr. Opin. Infect. Dis. 21:626-638.
    • (2008) Curr. Opin. Infect. Dis. , vol.21 , pp. 626-638
    • Lackenby, A.1    Thompson, C.2    Democratis, J.3
  • 27
    • 38549150173 scopus 로고    scopus 로고
    • Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble
    • Landon, M. R., et al. 2008. Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble. Chem. Biol. Drug Des. 71:106-116.
    • (2008) Chem. Biol. Drug Des. , vol.71 , pp. 106-116
    • Landon, M.R.1
  • 28
    • 18044386993 scopus 로고    scopus 로고
    • Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics
    • DOI 10.1128/JVI.79.11.6763-6771.2005
    • Lu, B., H. Zhou, D. Ye, G. Kemble, and H. Jin. 2005. Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics. J. Virol. 79:6763-6771. (Pubitemid 40677308)
    • (2005) Journal of Virology , vol.79 , Issue.11 , pp. 6763-6771
    • Lu, B.1    Zhou, H.2    Ye, D.3    Kemble, G.4    Jin, H.5
  • 29
    • 0037770271 scopus 로고    scopus 로고
    • Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors
    • Matrosovich, M., T. Matrosovich, J. Carr, N. A. Roberts, and H. D. Klenk. 2003. Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors. J. Virol. 77:8418-8425.
    • (2003) J. Virol. , vol.77 , pp. 8418-8425
    • Matrosovich, M.1    Matrosovich, T.2    Carr, J.3    Roberts, N.A.4    Klenk, H.D.5
  • 31
    • 65149097183 scopus 로고    scopus 로고
    • Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season
    • Meijer, A., et al. 2009. Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season. Emerg. Infect. Dis. 15:552-560.
    • (2009) Emerg. Infect. Dis. , vol.15 , pp. 552-560
    • Meijer, A.1
  • 32
    • 38049093537 scopus 로고    scopus 로고
    • Sialic acid receptor detection in the human respiratory tract: Evidence for widespread distribution of potential binding sites for human and avian influenza viruses
    • Nicholls, J. M., A. J. Bourne, H. Chen, Y. Guan, and J. S. Peiris. 2007. Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir. Res. 8:73.
    • (2007) Respir. Res. , vol.8 , pp. 73
    • Nicholls, J.M.1    Bourne, A.J.2    Chen, H.3    Guan, Y.4    Peiris, J.S.5
  • 33
    • 33750583083 scopus 로고    scopus 로고
    • Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir
    • Rameix-Welti, M. A., et al. 2006. Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir. Antimicrob. Agents Chemother. 50:3809-3815.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3809-3815
    • Rameix-Welti, M.A.1
  • 34
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 35
    • 37549059232 scopus 로고    scopus 로고
    • Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors
    • Richard, M., et al. 2008. Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors. J. Clin. Virol. 41:20-24.
    • (2008) J. Clin. Virol. , vol.41 , pp. 20-24
    • Richard, M.1
  • 36
    • 0020520729 scopus 로고
    • Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin
    • Rogers, G. N., and J. C. Paulson. 1983. Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127:361-373.
    • (1983) Virology , vol.127 , pp. 361-373
    • Rogers, G.N.1    Paulson, J.C.2
  • 38
    • 48749093648 scopus 로고    scopus 로고
    • Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity
    • Stevens, J., et al. 2008. Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J. Mol. Biol. 381:1382-1394.
    • (2008) J. Mol. Biol. , vol.381 , pp. 1382-1394
    • Stevens, J.1
  • 39
    • 77956823537 scopus 로고    scopus 로고
    • Antiviral susceptibility of avian and swine influenza of the N1 neuraminidase subtype
    • Stoner, T. D., et al. 2010. Antiviral susceptibility of avian and swine influenza of the N1 neuraminidase subtype. J. Virol. 84:9800-9809.
    • (2010) J. Virol. , vol.84 , pp. 9800-9809
    • Stoner, T.D.1
  • 40
    • 67651124941 scopus 로고    scopus 로고
    • Molecular evolution of H5N1 in Thailand between 2004 and 2008
    • Suwannakarn, K., et al. 2009. Molecular evolution of H5N1 in Thailand between 2004 and 2008. Infect. Genet. Evol. 9:896-902.
    • (2009) Infect. Genet. Evol. , vol.9 , pp. 896-902
    • Suwannakarn, K.1
  • 41
    • 2442667775 scopus 로고    scopus 로고
    • Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host
    • Thompson, C. I., W. S. Barclay, and M. C. Zambon. 2004. Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host. J. Antimicrob. Chemother. 53:759-765.
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 759-765
    • Thompson, C.I.1    Barclay, W.S.2    Zambon, M.C.3
  • 42
    • 0033961667 scopus 로고    scopus 로고
    • Monitoring of viral susceptibility: New challenges with the development of influenza NA inhibitors
    • Tisdale, M. 2000. Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors. Rev. Med. Virol. 10:45-55.
    • (2000) Rev. Med. Virol. , vol.10 , pp. 45-55
    • Tisdale, M.1
  • 43
    • 56049117953 scopus 로고    scopus 로고
    • Molecular epidemiological analysis of highly pathogenic avian influenza H5N1 subtype isolated from poultry and wild bird in Thailand
    • Uchida, Y., et al. 2008. Molecular epidemiological analysis of highly pathogenic avian influenza H5N1 subtype isolated from poultry and wild bird in Thailand. Virus Res. 138:70-80.
    • (2008) Virus Res. , vol.138 , pp. 70-80
    • Uchida, Y.1
  • 44
    • 0031820967 scopus 로고    scopus 로고
    • The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction
    • Vines, A., et al. 1998. The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J. Virol. 72:7626-7631. (Pubitemid 28377900)
    • (1998) Journal of Virology , vol.72 , Issue.9 , pp. 7626-7631
    • Vines, A.1    Wells, K.2    Matrosovich, M.3    Castrucci, M.R.4    Ito, T.5    Kawaoka, Y.6
  • 45
    • 54949123445 scopus 로고    scopus 로고
    • Evolution of highly pathogenic H5N1 avian influenza viruses in Vietnam between 2001 and 2007
    • Wan, X.-F., et al. 2008. Evolution of highly pathogenic H5N1 avian influenza viruses in Vietnam between 2001 and 2007. PLoS One 3:e3462.
    • (2008) PLoS One , vol.3
    • Wan, X.-F.1
  • 47
    • 12244295453 scopus 로고    scopus 로고
    • Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: Report of the neuraminidase inhibitor susceptibility network
    • Wetherall, N. T., et al. 2003. Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network. J. Clin. Microbiol. 41:742-750.
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 742-750
    • Wetherall, N.T.1
  • 48
    • 0027162942 scopus 로고
    • 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetyl-neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro
    • Woods, J. M., et al. 1993. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetyl- neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. Antimicrob. Agents Chemother. 37:1473-1479.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1473-1479
    • Woods, J.M.1
  • 49
    • 33645421057 scopus 로고    scopus 로고
    • 18 October 2010. World Health Organization, Geneva, Switzerland
    • World Health Organization. 2010. Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO, 18 October 2010. World Health Organization, Geneva, Switzerland. http://www.who.int/csr/disease/avian- influenza/country/cases-table-2010-10-18/en/index.html.
    • (2010) Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO
  • 50
    • 25844474747 scopus 로고    scopus 로고
    • Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility
    • Yen, H.-L., et al. 2005. Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility. Antimicrob. Agents Chemother. 49:4075-4084.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 4075-4084
    • Yen, H.-L.1
  • 51
    • 33748645733 scopus 로고    scopus 로고
    • Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses
    • Yen, H. L., et al. 2006. Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses. J. Virol. 80:8787-8795.
    • (2006) J. Virol. , vol.80 , pp. 8787-8795
    • Yen, H.L.1
  • 52
    • 23244456655 scopus 로고    scopus 로고
    • Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice
    • Yen, H. L., A. S. Monto, R. G. Webster, and E. A. Govorkova. 2005. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J. Infect. Dis. 192:665-672.
    • (2005) J. Infect. Dis. , vol.192 , pp. 665-672
    • Yen, H.L.1    Monto, A.S.2    Webster, R.G.3    Govorkova, E.A.4
  • 53
    • 0035054088 scopus 로고    scopus 로고
    • Position statement: Global neuraminidase inhibitor susceptibility network
    • Zambon, M., and F. G. Hayden. 2001. Position statement: global neuraminidase inhibitor susceptibility network. Antiviral Res. 49:147-156.
    • (2001) Antiviral Res. , vol.49 , pp. 147-156
    • Zambon, M.1    Hayden, F.G.2


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