Skin cleansers: The risks of chlorhexidine

Journal of Clinical Pharmacology

Volumn 51, Issue 5, 2011, Pages 785-786

  Sivathasan, Niroshan ^a,c   Goodfellow, Peter Bryan ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b CHESTERFIELD ROYAL HOSPITAL   (United Kingdom)

^c Apt 221 St George's Mill ^*  (United Kingdom)

Author keywords

adverse reaction; anaphylaxis; Chlorhexidine; complications; sensitization

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ATRACURIUM; CETIRIZINE; CHLORHEXIDINE; DEXAMETHASONE; INOTROPIC AGENT;

ADULT; ARTICLE; BLOOD PRESSURE; CASE REPORT; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DYSPNEA; HUMAN; HYPOTENSION; LAPAROSCOPY; MALE; OXYGEN SATURATION; RESUSCITATION; SHOCK; SIDE EFFECT; SKIN TEST; TONGUE SWELLING;

AGED; ANAPHYLAXIS; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DRUG HYPERSENSITIVITY; HUMANS; LAPAROSCOPY; MALE; PREOPERATIVE CARE; RISK ASSESSMENT; SHOCK; SKIN;

EID: 79955543275     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270010372628     Document Type: Article

References (14)

1. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999. Am J Infect Control. 1999 ; 27: 97-132
2. Surgical Site Infection (Clinical Guideline 74). London, United Kingdom: National Institute for Health and Clinical Excellence ; 2008 :
3. Hemani ML, Lepor H. Skin preparation for the prevention of surgical site infection: which agent is best?. Rev Urol. 2009 ; 11: 190-195
4. Digison MB. A review of anti-septic agents for pre-operative skin preparation. Plast Surg Nurs. 2007 ; 27: 185-8
5. Reichman DE, Greenberg JA. Reducing surgical site infections: a review. Rev Obstet Gynecol. 2009 ; 2: 212-221
6. Douw CM, Bulstra SK, Vandenbroucke J, Geesink RG, Vermeulen A. Clinical and pathological changes in the knee after accidental chlorhexidine irrigation during arthroscopy: case reports and review of the literature. J Bone Joint Surg Br. 1998 ; 80: 437-440
7. Thong BY, Yeow C. Anaphylaxis during surgical and interventional procedures. Ann Allergy Asthma Immunol. 2004 ; 92: 619-628 (Pubitemid 39243151)
8. Jee R, Nel L, Gnanakumaran G, Williams A, Eren E. Four cases of anaphylaxis to chlorhexidine impregnated central venous catheters: a case cluster or the tip of the iceberg?. Br J Anaesth. 2009 ; 103: 614-615
9. Pham NH, Weiner JM, Reisner GS, Baldo BA. Anaphylaxis to chlorhexidine: case report: implication of immunoglobulin E antibodies and identification of an allergenic determinant. Clin Exp Allergy. 2000 ; 30: 1001-1007 (Pubitemid 30427042)
10. Lim KS, Kam PC. Chlorhexidine-pharmacology and clinical applications. Anaesth Intensive Care. 2008 ; 36: 502-512
11. Sharma A, Chopra H. Chlorhexidine urticaria: a rare occurrence with a common mouthwash. Indian J Dent Res. 2009 ; 20: 377-379
12. Chisholm DG, Calder I, Peterson D, Powell M, Moult P. Intranasal chlorhexidine resulting in anaphylactic circulatory arrest. BMJ. 1997 ; 315: 785 (Pubitemid 27405946)
13. Bae YJ, Park CS, Lee JK, et al. A case of anaphylaxis to chlorhexidine during digital rectal examination. J Korean Med Sci. 2008 ; 23: 526-528
14. Ebo DG, Bridts CH, Stevens WJ. Anaphylaxis to an urethral lubricant: chlorhexidine as the "hidden" allergen. Acta Clin Belg. 2004 ; 59: 358-360 (Pubitemid 40395405)