A novel 60kDa reactivity in cyclic neutropenia: High titer cytoplasmic ANCA immunostaining pattern and negative anti-proteinase-3 antibody

Joint Bone Spine

Volumn 78, Issue 3, 2011, Pages 319-320

  Rodrigues, Camila E ^a   Velloso, Elvira R P ^a   Pereira, Rosa M R ^a   Bonfá, Eloísa ^a   Teixeira, Flávia K ^a   Bueno, Cleonice ^a   Dorlhiac Laccer, Pedro E ^a   Kondo, Andréa T ^a   Viana, Vilma S T ^a   Carvalho, Jozélio F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

ANCA; Autoantibodies; Cyclic neutropenia; Filgastrim; G CSF; Neutropenia

Indexed keywords

CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; BIOLOGICAL MARKER;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; LETTER; MALE; NEUTROPENIA; NEUTROPHIL COUNT; CYTOPLASM; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NEUTROPHIL; PATHOLOGY;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BIOLOGICAL MARKERS; CYTOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MIDDLE AGED; MYELOBLASTIN; NEUTROPENIA; NEUTROPHILS;

EID: 79955542942     PISSN: 1297319X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbspin.2010.10.001     Document Type: Letter

References (9)

1. Lima C.S., Paula E.V., Takahashi T., et al. Causes of incidental neutropenia in adulthood. Ann Hematol 2006, 85:705-709.
2. Shastri K.A., Logue G.L. Autoimmune neutropenia. Blood 1993, 81:1984-1995.
3. Fauci A.S., Haynes B.F., Katz P., et al. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983, 98:76-85.
4. Gonçalves C., Pinaffi J.V., Carvalho J.F., et al. Antineutrophile cytoplasmic antibodies in chronic rhinosinusitis may be a marker of undisclosed vasculitis. Am J Rhinol 2007, 21:691-694.
5. Dale D.C., Hammond W.P. Cyclic neutropenia: a clinical review. Blood Rev 1988, 2:178-185.
6. Aprikyan A.A., Liles W.C., Rodger E., et al. Impaired survival of bone marrow hematopoietic progenitor cells in cyclic neutropenia. Blood 2001, 97:147-153.
7. Benson K.F., Li F.Q., Person R.E., et al. Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophile elastase. Nat Genet 2003, 35:90-96.
8. Köllner I., Sodeik B., Schreek S., et al. Mutations in neutrophile elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and ninduction of the unfolded protein response. Blood 2006, 108:493-500.
9. Reed J.H., Jackson M.W., Gordon T.P. B cell apotopes of the 60-kDa Ro/SSA and La/SSB autoantigens. J Autoimmun 2008, 31:263-267.