Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress

Phytotherapy Research

Volumn 25, Issue 5, 2011, Pages 659-667

  Yehuda, Itamar ^a   Madar, Zecharia ^b   Szuchman Sapir, Andrea ^a   Tamir, Snait ^a,c  

^a MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c TEL HAI COLLEGE   (Israel)

Author keywords

antioxidant enzymes; atherosclerosis; chronic glucose stress; glabridin; oxidative stress; paraoxonase 2

Indexed keywords

ARYLDIALKYLPHOSPHATASE 2; CATALASE; ESTRADIOL; GLABRIDIN; GLUCOSE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PHYTOESTROGEN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION REGULATION; GLYCYRRHIZA; HUMAN; HUMAN CELL; LEUKEMIA CELL; MACROPHAGE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; UPREGULATION;

ANIMALS; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; CATALASE; CELL LINE; ESTRADIOL; FEMALE; GLUCOSE; GLYCYRRHIZA; HUMANS; ISOFLAVONES; MACROPHAGES; MICE; MONOCYTES; OXIDATIVE STRESS; PHENOLS; PHYTOESTROGENS; PLANT ROOTS; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; SUPEROXIDE DISMUTASE; UP-REGULATION;

GLYCYRRHIZA;

EID: 79955539302     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3318     Document Type: Article

References (44)

1. Aviram M, Rosenblat M, Billecke S, et al. 1999. Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radic Biol Med 26: 892-904. (Pubitemid 29198362)
2. Basta G, Schmidt AM, De Caterina R,. 2004. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res 63: 582-592. (Pubitemid 39078671)
3. Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J,. 1998. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 137: 49-61. (Pubitemid 28175376)
4. Choi EM,. 2005. The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochem Pharmacol 70: 363-368.
5. Fortunato G, Di Taranto MD, Bracale UM, et al. 2008. Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis. Arterioscler Thromb Vasc Biol 28: 594-600.
6. Halliwell B, Whiteman M,. 2004. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142: 231-255. (Pubitemid 38746160)
7. Hansson GK,. 2005. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352: 1685-1695.
8. Hayashi T, Juliet PA, Miyazaki A, Ignarro LJ, Iguchi A,. 2007. High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis. Biochim Biophys Acta 1772: 364-372. (Pubitemid 46275435)
9. Hayek T, Kaplan M, Kerry R, Aviram M,. 2007. Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for d -glucose. Atherosclerosis 195: 277-286. (Pubitemid 350087956)
10. Horke S, Witte I, Wilgenbus P, Kruger M, Strand D, Forstermann U,. 2007. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation 115: 2055-2064. (Pubitemid 46625957)
11. Kanaya AM, Herrington D, Vittinghoff E, et al. 2003. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 138: 1-9. (Pubitemid 36232088)
12. Kang JS, Yoon YD, Han MH, et al. 2006. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol Pharmacol 69: 941-949.
13. Karpuzoglu E, Ahmed SA,. 2006. Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis. Nitric Oxide 15: 177-186. (Pubitemid 44479839)
14. Lusis AJ,. 2000. Atherosclerosis. Nature 407: 233-241.
15. Mackness B, McElduff P, Mackness MI,. 2005. The paraoxonase-2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus. J Intern Med 258: 363-368.
16. Masding MG, Stears AJ, Burdge GC, Wootton SA, Sandeman DD,. 2003. Premenopausal advantages in postprandial lipid metabolism are lost in women with type 2 diabetes. Diabetes Care 26: 3243-3249. (Pubitemid 37466882)
17. Masding MG, Stears AJ, Burdge GC, Wootton SA, Sandeman DD,. 2006. The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes. Diabet Med 23: 768-774. (Pubitemid 44366076)
18. Mastorikou M, Mackness B, Liu Y, Mackness M,. 2008. Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides. Diabet Med 25: 1049-1055.
19. Mazzone T, Chait A, Plutzky J,. 2008. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet 371: 1800-1809. (Pubitemid 351697956)
20. Mendelsohn ME, Karas RH,. 1999. The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1811. (Pubitemid 29266405)
21. Ng CJ, Bourquard N, Grijalva V, et al. 2006. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem 281: 29491-29500. (Pubitemid 44536957)
22. Paravicini TM, Touyz RM,. 2008. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 31 (Suppl 2): S170-S180.
23. Pieske B, Wachter R,. 2008. Impact of diabetes and hypertension on the heart. Curr Opin Cardiol 23: 340-349. (Pubitemid 351787099)
24. Preis SR, Hwang SJ, Coady S, et al. 2009. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation 119: 1728-1735.
25. Rosenblat M, Belinky P, Vaya J, et al. 1999. Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. J Biol Chem 274: 13790-13799.
26. Rosenblat M, Coleman R, Aviram M,. 2002. Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 163: 17-28. (Pubitemid 34615722)
27. Rosenblat M, Coleman R, Reddy ST, Aviram M,. 2009. Paraoxonase 2 (PON2) attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1 (DGAT1), the rate limiting enzyme in triglycerides biosynthesis. J Lipid Res 50: 870-879.
28. Rosenblat M, Draganov D, Watson CE, Bisgaier CL, La Du BN, Aviram M,. 2003. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Arterioscler Thromb Vasc Biol 23: 468-474. (Pubitemid 36337224)
29. Rosenblat M, Hayek T, Hussein K, Aviram M,. 2004. Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. Arterioscler Thromb Vasc Biol 24: 175-180. (Pubitemid 38082430)
30. Ross R,. 1999. Atherosclerosis-an inflammatory disease. N Engl J Med 340: 115-126. (Pubitemid 29054847)
31. Shah S, Iqbal M, Karam J, Salifu M, McFarlane SI,. 2007. Oxidative stress, glucose metabolism, and the prevention of type 2 diabetes: pathophysiological insights. Antioxid Redox Signal 9: 911-929. (Pubitemid 46919593)
32. Somjen D, Katzburg S, Kohen F, et al. 2006. Responsiveness to estradiol-17beta and to phytoestrogens in primary human osteoblasts is modulated differentially by high glucose concentration. J Steroid Biochem Mol Biol 99: 139-146. (Pubitemid 43152184)
33. Somjen D, Katzburg S, Vaya J, et al. 2004a. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol 91: 241-246. (Pubitemid 39164607)
34. Somjen D, Knoll E, Vaya J, Stern N, Tamir S,. 2004b. Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. J Steroid Biochem Mol Biol 91: 147-155. (Pubitemid 38992809)
35. Somjen D, Paller CJ, Gayer B, Kohen F, Knoll E, Stern N,. 2004c. High glucose blocks the effects of estradiol on human vascular cell growth: differential interaction with estradiol and raloxifene. J Steroid Biochem Mol Biol 88: 101-110. (Pubitemid 38326602)
36. Strehlow K, Rotter S, Wassmann SG, et al. 2003. Modulation of antioxidant enzyme expression and function by estrogen. Circ Res 93: 170-177. (Pubitemid 36919705)
37. Sztejnsznajd C, Silva ME, Nussbacher A, et al. 2006. Estrogen treatment improves arterial distensibility, fibrinolysis, and metabolic profile in postmenopausal women with type 2 diabetes mellitus. Metabolism 55: 953-959. (Pubitemid 43902899)
38. Tamir S, Eizenberg M, Somjen D, et al. 2000. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res 60: 5704-5709.
39. Vaya J, Mahmood S, Goldblum A, et al. 2003. Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy. Phytochemistry 62: 89-99. (Pubitemid 36869772)
40. Vina J, Sastre J, Pallardo FV, Gambini J, Borras C,. 2006. Role of mitochondrial oxidative stress to explain the different longevity between genders: protective effect of estrogens. Free Radic Res 40: 1359-1365. (Pubitemid 44698285)
41. Wassmann S, Wassmann K, Nickenig G,. 2006. Regulation of antioxidant and oxidant enzymes in vascular cells and implications for vascular disease. Curr Hypertens Rep 8: 69-78.
42. Weidig P, McMaster D, Bayraktutan U,. 2004. High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Diabetes Obes Metab 6: 432-441. (Pubitemid 39409794)
43. Yan H, Harding JJ,. 1997. Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochem J 328: 599-605. (Pubitemid 27515606)
44. Yu XQ, Xue CC, Zhou ZW, et al. 2008. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 82: 68-78. (Pubitemid 350251394)