Ketogenic diet in the treatment of seizures associated with hypothalamic hamartomas

Epilepsy Research

Volumn 94, Issue 3, 2011, Pages 218-221

  Chapman, Kevin E ^a   Kim, Do Young ^a   Rho, Jong M ^a   Ng, Yu Tze ^a   Kerrigan, John F ^a  

^a ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Hypothalamic hamartoma; Ketogenic diet

Indexed keywords

KETONE BODY;

ADOLESCENT; ADULT; ARTICLE; ATONIC SEIZURE; BRAIN ELECTROPHYSIOLOGY; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; DISEASE ASSOCIATION; FOCAL EPILEPSY; GELASTIC SEIZURE; HAMARTOMA; HUMAN; HUMAN TISSUE; HYPOTHALAMUS TUMOR; KETOGENIC DIET; MICROELECTRODE; NEUROMODULATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SEIZURE; TISSUE SLICE; TREATMENT DURATION; TREATMENT FAILURE;

ADOLESCENT; BRAIN WAVES; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; FEMALE; HAMARTOMA; HUMANS; HYPOTHALAMIC DISEASES; KETOGENIC DIET; MALE; RETROSPECTIVE STUDIES; SEIZURES;

EID: 79955524555     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.02.004     Document Type: Article

References (8)

1. Brandberg G., Raininko R., Eeg-Olofsson O. Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur. J. Pediatr. Neurol. 2004, 6:35-44.
2. Fenoglio K.A., Wu J., Kim, do Y., Simeone T.A., Coons S.W., Rekate H., Rho J.M., Kerrigan J.F. Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis. Semin. Pediatr. Neurol. 2007, 14:51-59.
3. Kerrigan J.F., Ng Y.T., Chung S., Rekate H.L. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin. Pediatr. Neurol. 2005, 12:119-131.
4. Kim, do Y., Davis L.M., Sullivan P.G., Maalouf M., Simeone T.A., van Brederode J., Rho J.M. Ketone bodies are protective against oxidative stress in neocortical neurons. J. Neurochem. 2007, 101:1316-1326.
5. A receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsia 2008, 49:861-871.
6. Kim, do Y., Rho J.M. The ketogenic diet and epilepsy. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11:113-120.
7. Palmini A., Paglioli-Neto E., Montes J., Farmer J.P. The treatment of patients with hypothalamic hamartomas, epilepsy and behavioral abnormalities: facts and hypotheses. Epileptic Disord. 2003, 5:249-255.
8. Papayannis C.E., Consalvo D., Seifer G., Kauffman M.A., Silva W., Kochen S. Clinical spectrum and difficulties in management of hypothalamic hamartoma in a developing country. Acta Neurol. Scand. 2008, 118:313-319.