Buprenorphine for the Treatment of Perinatal Opioid Dependence: Pharmacology and Implications for Antepartum, Intrapartum, and Postpartum Care

Journal of Midwifery and Women's Health

Volumn 56, Issue 3, 2011, Pages 240-247

  Goodman, Daisy ^a  

^a Franklin Memorial Hospital   (United States)

Author keywords

Buprenorphine; Neonatal abstinence; Perinatal opioid dependence; Pregnancy

Indexed keywords

BUPRENORPHINE; BUPRENORPHINE PLUS NALOXONE; FLUOXETINE; IBUPROFEN; MACROLIDE; METHADONE; METRONIDAZOLE; NALOXONE; OXYCODONE; OXYCODONE PLUS PARACETAMOL; PAROXETINE; SERTRALINE;

AMENORRHEA; ANALGESIC AGENT ABUSE; BINDING AFFINITY; BREAST MILK; BREATHING RATE; COMBINATION CHEMOTHERAPY; CONSTIPATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SAFETY; GASTROINTESTINAL MOTILITY; HUMAN; INTRAPARTUM CARE; MONOTHERAPY; NAUSEA; NEWBORN ASSESSMENT; PATIENT CARE; PERINATAL CARE; PERINATAL PERIOD; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RESPIRATION DEPRESSION; REVIEW; SIDE EFFECT; URINE RETENTION; WITHDRAWAL SYNDROME; XEROSTOMIA;

BUPRENORPHINE; FEMALE; HUMANS; NARCOTIC ANTAGONISTS; OFF-LABEL USE; OPIOID-RELATED DISORDERS; PERINATAL CARE; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 79955520816     PISSN: 15269523     EISSN: 15422011     Source Type: Journal    
DOI: 10.1111/j.1542-2011.2011.00049.x     Document Type: Review

References (51)

1. Substance Abuse and Mental Health Services Administration. Results from the 2009 National Survey on Drug Use and Health: Volume 1 Summary of National Findings. Rockville, MD Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4586;2009.
2. Drug Abuse Warning Network, Office of Applied Studies. Trends in Emergency Department Visits Involving Narcotic Pain Relievers. Rockville, MD 2010. Accessed October 1, 2010.
3. Jannson LM, Velez M, Harrow C. The opioid-exposed newborn: assessment and pharmacologic management. J Opioid Manag. 2009;5(1):47-55.
4. Fischer G, Ortner R, Rohrmeister K, et al. Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study. Addiction. 2006;101:275-281.
5. Minnozi S, Amato L, Vecchi S, Davoli M. Maintenance agonist treatments for opiate dependent pregnant women (Review). Cochrane Database Syst Rev. 2008:CD006318. DOI.
6. Johnson R, Jones J, Jasinski D et al. Buprenorphine treatment of pregnant, opioid dependent women: maternal and neonatal outcomes. Drug Alcohol Depend. 2001;63:97-103.
7. Jones H, Martin P, Heil S, et al. Treatment of opioid-dependent pregnant women: clinical and research issues. J Subst Abuse Treat. 2008;35:245-259.
8. Maine Office of Substance Abuse. Data Report: Maine Women Entering Substance Abuse Treatment 1997-2007. Portland Maine Lighthouse; 2009.
9. Winklbaur B, Kopf N, Ebner N, Jung E, Thau K, Fischer G. Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates. Addiction. 2008;103:1429-1440.
10. Binder T, Vavrinkova B. Prospective randomized comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the outpatient department. Neuroendocrinol Lett. 2008;29(1):80-86.
11. Velez M, Montoya ID, Jannson LM, et al. Exposure to violence among substance-dependent pregnant women and their children. J Subst Abuse Treat. 2006;30(1):31-38.
12. Kashiwagi M, Sieber S, Rechsteiner C, Lauper U, Zimmermann R, Elert U. Psychological mood state of opiate addicted women during pregnancy and postpartum in comparison to non-addicted healthy women. J Psychomsomat Obstet Gynecol. 2006;28(1):3-6.
13. Horrigan T, Schroeder A, Schaffer R. The triad of substance abuse, violence and depression are interrelated in pregnancy. J Subst Abuse Treat. 2006;18:55-58.
14. Merikangas K, Mehta R, Molnar B, et al. Comorbidity of substance use disorders with mood and anxiety disorders: results of the international consortium in psychiatric epidemiology. Addict Behav. 1998;23(6):893-907.
15. Moylan P, Jones H, Haug N, Kissin W, Svikis D. Clinical and psychosocial characteristics of substance-dependent pregnant women with and without PTSD. Addict Behav. 2001;26:469-474.
16. Lejeune C, Simmat-Durand L, Gourarier L, Aubisson S. Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenorphine substitution. Drug Alcohol Depend. 2005;82:250-257.
17. Bakstad B, Sarfi M, Welle-Strand G, Ravndal E. Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. European Addict Research. 2009;15:128-134.
18. Meier B, Patkar A. Buprenorphine treatment: factors and first-hand experiences for providers to consider. J Addict Dis. 2007;26(1):3-14.
19. Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Treatment Improvement Protocol (TIP) Series 40. DHHS Publication No. (SMA) 04-3939. Rockville, MD Substance Abuse and Mental Health Services Administration; 2004.
20. Johnson R, Strain E, Amass L. Buprenorphine: how to use it right. Drug Alcohol Depend. 2003;70:59-77.
21. Walsh S, Eissenberg T. The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic. Drug Alcohol Depend. 2003;70:13-27.
22. Mehta V, Langford R. Acute pain management for opioid dependent patients. Anaesthesia 2006;61:269-276.
23. Bogenschutz M, Aboott P, Kushner R, Tonigan J, Woody G. Effects of buprenorphine and hepatitis C on liver enzymes in adolescents and young adults. J Addict Med. 2010. Published ahead of print: Post-editor corrections July 13, 2010.
24. Center for Substance Abuse Treatment. Medication-Assisted Treatment for Opioid-Addiction During Pregnancy. Treatment Improvement Protocol (TIP) Series 43, Chapter 13. Rockville, MD Substance Abuse and Mental Health Services Administration; 2004.
25. Nanovskaya T, Deshmukh S, Brooks M, Ahmed M. Transplacental transfer and metabolism of buprenorphine. J Pharmacol Exp Ther. 2002;300(1):26-33.
26. Kacinko S, Jones H, Johnson R, Choo R, Huestis M. Correlations of maternal buprenorphine dose, buprenorphine and metabolite concentrations in meconium with neonatal outcomes. Clin Pharmacol Ther. 2008;156:1-9.
27. Tracy T, Venkataramanan R, Douglas D, Caritis S. Temporal changes in drug metabolism (CYP1A2, CYPD6, and CyP3A activity) during pregnancy. Am J Obstet Gynecol. 2005;192:633-639.
28. Hodge L, Tracy T. Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol. 2007;3(4):557-571.
29. Kakko J, Heilig M, Sarman I. Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. Drug Alcohol Depend. 2008;96:69-78.
30. Kahila H, Saisto T, Kivitie-Kallio S, Haukkama A, Halmesmaki E. A prospective study on buprenorphine use during pregnancy: effects on maternal and neonatal outcomes. Acta Obstet Gynecol. 2007;86:185-190.
31. Jones H, Johnson R, Jasinski D, et al. Buprenorphine versus methadone in the treatment of pregnant opioid dependent women: effect on the neonatal abstinence syndrome. Drug Alcohol Depend. 2005;79(1):1-10.
32. Johnson R, Jones H, Fischer G. Use of buprenorphine in pregnancy: patient management and effects on the neonate. Drug Alcohol Depend. 2003;70:87-101.
33. Jones H, Kaltenbach K, Heil S, et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med. 2010;363(24):2320-2331.
34. Grimm D, Pauly E, Poschl J, Linderkamp O, Skopp G. Buprenorphine and norbuprenorphine concentrations in human breast milk samples determined by liquid chromatography-tandem mass spectrometry. Ther Drug Monitor. 2005;27(4):526-530.
35. Abdel-Latif M, Pinner J, Clew S, Cooke F, Lui K, Oei J. Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent mothers. Pediatrics. 2006;117:1163-1169.
36. Kearney M. Truthful self-nurturing: a grounded formal theory of women's addiction recovery. Qual Health Res. 1998;8(4):495-512.
37. Helmbrecht G, Thiagarajah S. Management of addiction disorders in pregnancy. J Addict Med. 2008;2(1):1-16.
38. Haller D, Miles D. Victimization and perpetration among perinatal substance abusers. J Interpers Violence. 2003;18(7):760-780.
39. Hans S. Demographic and psychosocial characteristics of substance-abusing pregnant women. Clin Perinatol. 1999;26(1):55-74.
40. Jessup M, Brindis C. Issues in reproductive health and empowerment in perinatal women with substance use disorders. J Addict Nurs. 2005;16:97-105.
41. Jones H, Johnson R, Milio L. Post-cesarean pain management of patients maintained on methadone or buprenorphine. Am J Addict. 2006;15:258-259.
42. Jones H, O'Grady K, Johnson R, et al. Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. Am J Drug Alcohol Abuse. 2009;35:151-156.
43. Meyer M, Paranya G, Norris A, Howard D. Intrapartum and postpartum analgesia for women maintained on buprenorphine during pregnancy. Eur J Pain. In press.
44. Alford D, Compton P, Samet J. Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. Ann Intern Med. 2006;144:127-134.
45. Meyer M, Wagner K, Benvenuto A, Howard D, Plante D. Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. Obstet Gynecol 2007;110:261-266.
46. Mitra S, Sinatra R. Perioperative management of acute pain in the opioid dependent patient. Anesthesiology. 2004;101:212-227.
47. Hale, Thomas. Medications and Mothers' Milk. Texas Hale Publishing; 2008.
48. Liebert, M. ABM clinical protocol #21: guidelines for breastfeeding and the drug-dependent woman. Breastfeed Med. 2009;4(4):225-228.
49. Jansson L, Choo R, Velez M, et al. Methadone maintenance and breastfeeding in the neonatal period. Pediatrics. 2008;121:106-114.
50. Leggate J. Improving pregnancy outcomes: mothers and substance misuse. Br J Midwifery. 2008;16(3):160-165.
51. Boyd S, Marcellus L. With Child. Substance use During Pregnancy: A Woman-centred Approach. Nova Scotia Fernwood; 2007.