Cortical and trabecular bone, bone mineral density, and resistance to ex vivo fracture are not altered in response to life-long vitamin A supplementation in aging rats

Journal of Nutrition

Volumn 141, Issue 4, 2011, Pages 660-666

  Wray, Amanda E ^a   Okita, Nori ^a   Ross, A Catharine ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOL;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE REMODELING; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL BONE; DISEASE RESISTANCE; EX VIVO STUDY; FEMALE; FEMUR; FRACTURE; LONGITUDINAL STUDY; MALE; MATERIALS TESTING; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; RAT; TIBIA; TRABECULAR BONE; VITAMIN SUPPLEMENTATION; WEANING;

AGING; ANIMALS; BONE DENSITY; BONE REMODELING; DIETARY SUPPLEMENTS; FEMALE; FEMUR; FRACTURES, BONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; VITAMIN A;

RATTUS;

EID: 79955513257     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.132126     Document Type: Article

References (51)

1. Evans TR, Kaye SB. Retinoids: present role and future potential. Br J Cancer. 1999;80:1-8.
2. Ross AC, Harrison EH. Vitamin A. In: Zempleni J, Rucker RR, McCormick DM, Suttie JW, editors. Handbook of vitamins. 4th ed. Boca Raton (FL): CRC Press; 2007. p. 1-39.
3. Subcommittee on Vitamin Tolerance, Committee on Animal Nutrition, Council NR. Vitamin tolerance of animals. Washington, DC: National Academy Press; 1987.
4. Genaro Pde S, Martini LA. Vitamin A supplementation and risk of skeletal fracture. Nutr Rev. 2004;62:65-7.
5. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000. Am J Epidemiol. 2004;160:339-49.
6. Lim LS, Harnack LJ, Lazovich D, Folsom AR. Vitamin A intake and the risk of hip fracture in postmenopausal women: the Iowa Women's Health Study. Osteoporos Int. 2004;15:552-9.
7. Sowers MR, Wallace RB, Lemke JH. Correlates of mid-radius bone density among postmenopausal women: a community study. Am J Clin Nutr. 1985;41:1045-53.
8. Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM. The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese-American men and women living in Hawaii. Am J Clin Nutr. 1985;42:877-88.
9. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med. 2003;348:287-94.
10. Promislow JH, Goodman-Gruen D, Slymen DJ, Barrett-Connor E. Protein consumption and bone mineral density in the elderly: the Rancho Bernardo Study. Am J Epidemiol. 2002;155:636-44.
11. Penniston KL, Weng N, Binkley N, Tanumihardjo SA. Serum retinyl esters are not elevated in postmenopausal women with and without osteoporosis whose preformed vitamin A intakes are high. Am J Clin Nutr. 2006;84:1350-6.
12. Ross AC. Vitamin A and carotenoids. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and disease. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 351-75.
13. Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PA. Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake. J Biol Chem. 1989;264:9571-82.
14. Hussain MM, Mahley RW, Boyles JK, Lindquist PA, Brecht WJ, Innerarity TL. Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species. J Biol Chem. 1989;264:17931-8.
15. Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen PC, Heeren J. Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function. Bone. 2008;43:230-7.
16. Twining SS, Schulte DP, Wilson PM, Fish BL, Moulder JE. Retinol is sequestered in the bone marrow of vitamin A-deficient rats. J Nutr. 1996;126:1618-26.
17. Morgan SL. Nutrition and bone: it is more than calcium and vitamin D. Womens Health (Lond Engl). 2009;5:727-37.
18. Freudenheim JL, Johnson NE, Smith EL. Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: longitudinal and cross-sectional analysis. Am J Clin Nutr. 1986;44: 863-76.
19. Sowers MF, Wallace RB. Retinol, supplemental vitamin A and bone status. J Clin Epidemiol. 1990;43:693-9.
20. Houtkooper LB, Ritenbaugh C, Aickin M, Lohman TG, Going SB, Weber JL, Greaves KA, Boyden TW, Pamenter RW, Hall MC. Nutrients, body composition and exercise are related to change in bone mineral density in premenopausal women. J Nutr. 1995;125:1229-37.
21. Melhus H, Michaelsson K, Kindmark A, Bergstrom R, Holmberg L, Mallmin H, Wolk A, Ljunghall S. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med. 1998;129:770-8.
22. Johansson S, Lind PM, Hakansson H, Oxlund H, Orberg J, Melhus H. Subclinical hypervitaminosis A causes fragile bones in rats. Bone. 2002;31: 685-9.
23. Kaptoge S, Welch A, McTaggart A, Mulligan A, Dalzell N, Day NE, Bingham S, Khaw KT, Reeve J. Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age. Osteoporos Int. 2003;14:418-28.
24. Michaelsson K, Melhus H, Bellocco R, Wolk A. Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. Bone. 2003;32: 694-703.
25. Macdonald HM, New SA, Golden MH, Campbell MK, Reid DM. Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr. 2004;79:155-65.
26. Kneissel M, Studer A, Cortesi R, Susa M. Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents. Bone. 2005;36:202-14.
27. Barker ME, McCloskey E, Saha S, Gossiel F, Charlesworth D, Powers HJ, Blumsohn A. Serum retinoids and beta-carotene as predictors of hip and other fractures in elderly women. J Bone Miner Res. 2005;20: 913-20.
28. Lind PM, Johansson S, Ronn M, Melhus H. Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. Chem Biol Interact. 2006;159:73-80.
29. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006;83:191-201.
30. Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, Snetselaar LG, Chen Z. Vitamin A and retinol intakes and the risk of fractures among participants of theWomen's Health Initiative Observational Study. Am J Clin Nutr. 2009;89:323-30.
31. Cashin CH, Lewis EJ. Evaluation of hypervitaminosis A in the rat by measurement of tibial bone breaking strain. J Pharmacol Methods. 1984;11:91-5.
32. Subcommittee on Laboratory Animal Nutrition, Committee on Animal Nutrition Board on Agriculture, National Research Council. Nutrient requirements of laboratory animals. In: Nutrient requirements of laboratory animals. 4th rev ed. Washington, DC: National Academy Press; 1995.
33. Dawson HD, Li NQ, DeCicco KL, Nibert JA, Ross AC. Chronic marginal vitamin A status reduces natural killer cell number and function in aging Lewis rats. J Nutr. 1999;129:1510-7.
34. Dawson HD, Ross AC. Chronic marginal vitamin A status affects the distribution and function of T cells and natural T cells in aging Lewis rats. J Nutr. 1999;129:1782-90.
35. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51. PubMed
36. Reeves PG, Rossow KL, Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcifica-tion and bone mineralization in rats and mice. J Nutr. 1993;123: 1923-31.
37. Ross AC. Diet in vitamin A research. Methods Mol Biol. 2010;652: 295-313.
38. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497-509.
39. Ross AC. Separation and quantitation of retinyl esters and retinol by highperformance liquid chromatography. Methods Enzymol. 1986;123:68-74.
40. Shahnazari M, Lang DH, Fosmire GJ, Sharkey NA, Mitchell AD, Leach RM. Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength. Calcif Tissue Int. 2007;80:160-6.
41. Martin RB, Burr DB, Sharkey NA. Mechanical properties of bone. Skeletal tissue mechanics. New York: Springer; 1998. p. 127-80
42. Dawson HD, Yamamoto Y, Zolfaghari R, Rosales FJ, Dietz J, Shimada T, Li N, Ross AC. Regulation of hepatic vitamin A storage in a rat model of controlled vitamin A status during aging. J Nutr. 2000;130: 1280-6.
43. Zolfaghari R, Ross AC. Chronic vitamin A intake affects the expression of mRNA for apolipoprotein A-I, but not for nuclear retinoid receptors, in liver of young and aging Lewis rats. Arch Biochem Biophys. 1995;323:258-64.
44. Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Playing with bone and fat. J Cell Biochem. 2006;98:251-66.
45. Niemeier A, Kassem M, Toedter K, Wendt D, Ruether W, Beisiegel U, Heeren J. Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. J Bone Miner Res. 2005;20:283-93.
46. Clagett-Dame M, DeLuca HF. The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr. 2002;22: 347-81.
47. Frost HM. The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs. J Bone Miner Metab. 2000;18:305-16.
48. Frost HM. From Wolff's law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat Rec. 2001;262: 398-419.
49. Frost HM. Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol. 2003;275:1081-101.
50. Kawahara TN, Krueger DC, Engelke JA, Harke JM, Binkley NC. Shortterm vitamin A supplementation does not affect bone turnover in men. J Nutr. 2002;132:1169-72.
51. Vestergaard P, Rejnmark L, Mosekilde L. High-dose treatment with vitamin A analogues and risk of fractures. Arch Dermatol. 2010;146: 478-82.