Evaluation of Origanum vulgare L. ssp. viridis leaves extract effect on discrimination learning and LTP induction in the CA1 region of the rat hippocampus

Iranian Journal of Basic Medical Sciences

Volumn 14, Issue 2, 2011, Pages 177-184

  Sheibani, Vahid ^a,c   Afarinesh, Mohammadreza ^a   Hajializadeh, Zahra ^a   Abbasnejad, Mehdi ^b   Tahereh, Haghpanah ^a   Arabnezhad, Razieh ^c   Sepehri, Gholamreza ^a  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant assay; Long term potentiation; Medicinal plant; Origanum vulgare; Spatial learning; T maze

Indexed keywords

ORIGANUM VULGARE EXTRACT; PLANT EXTRACT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISCRIMINATION LEARNING; ELECTROPHYSIOLOGY; EVALUATION; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MAZE TEST; NONHUMAN; OREGANO; RAT; STATISTICAL ANALYSIS; STIMULATION; WISTAR RAT;

ANIMALIA; ORIGANUM; ORIGANUM VULGARE; RATTUS; RATTUS NORVEGICUS;

EID: 79955506330     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Goun E, Cunningham G, Solodnikov S, Krasnykch O, Miles H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002; 73:692-694.
2. Salah SM, Jager AK.Screening of traditionally used Lebanese herbs for neurological activities. J Ethnopharmacol 2005; 97:145-149.
3. Chorianopoulos N, Kalpoutzakis E, Aligiannis N, Mitaku S, Nychas GJ, Haroutounian SA. Essential oils of Satureja, Origanum, and Thymus species: chemical composition and antibacterial activities against foodborne pathogens. J Agric Food Chem 2004; 52:8261-8267.
4. Rechinger K-H, Druk A. Flora iranica, Labiatae: Verlagsoutalt Austria; 1982.
5. Van Den Broucke CO, Lemli JA. Antispasmodic activity of Origanum compactum. Planta Med 1980; 38:317-331.
6. Lemhardi A, Zeggwagh NA, Maghrani M, Jouad H, Eddouks M. Anti- hyperglycaemic activity of the aqueous extract of Origanum Vulgare growing wild in Tafilalet region. Ethnopharmacol 2004; 92:251-256.
7. Kulisic T, Krisko A, Dragovic-Uzelac V, Milos M, Pifat G. The effects of essential oils and aqueous tea infusions of oregano (Origanum vulgare L. spp. hirtum), thyme (Thymus vulgaris L.) and wild thyme (Thymus serpyllum L.) on the copper-induced oxidation of human low-density lipoproteins. Int J Food Sci Nutr 2007; 58:87-93.
8. Matsuura H, Chiji H, Asakawa C, Amano M, Yoshihara T, Mizutani J. DPPH radical scavengers from dried leaves of Oregano (Origanum vulgare). Biosci Biotechnol Biochem 2003; 67:2311-2316.
9. Vagi E, Rapavi E, Hadolin M, Vasarhelyine Peredi K, Balazs A, Blazovics A, et al. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J Agric Food Chem 2005; 53:17-21.
10. Heo HJ, Cho HY, Hong B, Kim HK, Heo TR, Kim EK, et al. Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. Mol Cells 2002; 13:5-11.
11. Kulisic T, Radonic A, Katalinic V, Milos M. Use of different methods for testing antioxidative activity ofOregano essential oil. Food Chem 2004; 85: 633-640.
12. Rodriguez-Meizoso I, Marin FR, Herrero M, Senorans FJ, Reglero G, Cifuentes A, et al. Subcritical water extraction of nutraceuticals with antioxidant activity from Oregano. Chemical and functional characterization. J Pharm Biomed Anal 2006; 41:1560-1565.
13. Youdim KA, Deans SG. Beneficial effects of thyme oil on age-related changes in the phospholipid C20 and C22 polyunsaturated fatty acid composition of various rat tissues. Biochim Biophys Acta 1999; 1438:140-146.
14. Kiray M, Bagriyanik HA, Pekcetin C, Ergur BU, Uysal N, Ozyurt D, et al. Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats. Physiol Res 2006; 55:205-212.
15. Grundman M. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr 2000; 71:630S-636S.
16. Alkam T, Nitta A, Mizoguchi H, Itoh A, Nabeshima T. A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35). Behav Brain Res 2007; 180:139-145.
17. Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res 2005; 52:199-203.
18. Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Takeuchi F, et al. Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. Free Radic Res 2005; 39:995-1003.
19. Castegna A, Thongboonkerd V, Klein JB, Lynn B, Markesbery WR, Butterfield DA. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem 2003; 85:1394-1401.
20. Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, et al. Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction. Mol Psychiatry 2003; 8:407-412.
21. Blomhoff R. [Antioxidants and oxidative stress]. Tidsskr Nor Laegeforen 2004; 124:1643-1645.
22. Lynch MA. Long-term potentiation and memory. Physiol Rev 2004; 84:87-136.
23. Hu D, Serrano F, Oury TD, Klann E. Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase. J Neurosci 2006; 26:3933-3941.
24. Watson JB, Arnold MM, Ho YS, O'Dell TJ. Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes. J Neurosci Res 2006; 84:1564-1574.
25. Annett LE, McGregor A, Robbins TW. The effects of ibotenic acid lesions of the nucleus accumbens on spatial learning and extinction in the rat. Behav Brain Res 1989; 31:231-242.
26. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Academic Press San Diego, CA, USA: 1986.
27. Dong Z, Cao J, Xu L. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience 2007; 144:845-854.
28. Harborne JB. Phytochemical Methods. London: Chapman and Halls; 1998.
29. Miller NJ, Rice-Evans CA. Factors influencing the antioxidant activity determined by the ABTS.+ radical cation assay. Free Radic Res 1997; 26:195-199.
30. Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim Y, et al. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol Cells 2001; 11:137-143.
31. Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J Neurosci Res 2004; 75:742-750.
32. Bliss T, Collingridge G. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361:31-39.
33. Andrasfalvy BK, Magee JC. Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones. J Physiol 2004; 559:543-554.
34. Wang JH, Kelly PT. Postsynaptic injection of CA2+/CaM induces synaptic potentiation requiring CaMKII and PKC activity. Neuron 1995; 15:443-452.
35. Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982; 297:681-683.
36. Watson DJ, Stanton ME. Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats. Neurobiol Learn Mem 2009; 92:89-98.
37. Morris RG, Halliwell RF, Bowery N. Synaptic plasticity and learning. II: Do different kinds of plasticity underlie different kinds of learning? Neuropsychologia 1989; 27:41-59.
38. Staubli U, Thibault O, DiLorenzo M, Lynch G. Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory. Behav Neurosci 1989; 103:54-60.
39. Miserendino MJ, Sananes CB, Melia KR, Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 1990; 345:716-718.
40. Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, et al. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News Perspect 2005; 18:13-19.
41. Mecocci P, Mariani E, Cornacchiola V, Polidori MC. Antioxidants for the treatment of mild cognitive impairment. Neurol Res 2004; 26:598-602.
42. Serrano F, Klann E. Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev 2004; 3:431-443.
43. Dorman HJ, Bachmayer O, Kosar M, Hiltunen R. Antioxidant properties of aqueous extracts from selected lamiaceae species grown in Turkey. J Agric Food Chem 2004; 52:762-770.
44. Kim JS, Huh JI, Song SH, Shim KH, Back BS, Kim KW, et al. The antioxidative mechanism of ursolic acid. J Gastroenterol 1996; 6:52-56.
45. Chang Q, Gold PE. Switching memory systems during learning: changes in patterns of brain acetylcholine release in the hippocampus and striatum in rats. J Neurosci 2003; 23:3001-3005.