Effect of the missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic

Czech Journal of Animal Science

Volumn 56, Issue 4, 2011, Pages 176-180

  Dvorakova V ^a   Stupka R ^a   Sprysl M ^a   Citek J ^a   Okrouhla M ^a   Kluzakova E ^a   Kratochvilova H ^a  

^a CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

Author keywords

Fatness; Growth; MC4R; Pig

Indexed keywords

SUIDAE;

EID: 79955497837     PISSN: 12121819     EISSN: None     Source Type: Journal    
DOI: 10.17221/1305-cjas     Document Type: Article

References (19)

1. Barb CR., Robertson A.S., Barrett J.B., Kraeling R.R., Houseknecht K.L. (2004): The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig. Journal of Endocrinology, 181, 39-52.
2. Cone R.D. (1999): The central melanocortin system and energy homeostasis. Trends in Endocrinology and Metabolism, 10, 211-216.
3. Fan B., Onteru S.K., Plastow G.S., Rothschild M.F. (2009): Detailed characterization of the porcine MC4R gene in relation to fatness and growth. Animal Genetics, 40, 401-409.
4. Hernández-Sánchez J., Visscher P., Plastow G., Haley Ch. (2003): Candidate gene analysis for quantitative traits using the transmission disequilibrium test: The example of the melanocortin-4 receptor in pigs. Genetics, 164, 637-644.
5. Houston R.D., Cameron N.D., Rance K.A. (2004): A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergendy selected large white pig populations. Animal Genetics, 35,386-390.
6. Jokubka R., Maak S., Kerziene S., Swalve H.H. (2006): Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. Journal of Animal Breeding and Genetics, 123,17-22.
7. Kim K.S., Larsen N.J., Rothschild M.F. (2000a): Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene. Journal of Animal Science, 78, 791-792.
8. Kim K.S., Larsen N., Short T., Plastow G., Rothschild M.F. (2000b): A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mammalian Genome, 11,131-135.
9. Kim K.S., Reecy J.M., Hsu W.H., Anderson L.L., Rothschild M.F. (2004a): Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pigs. Domestic Animal Endocrinology, 26,75-86.
10. Kim K.S., Thomsen H., Bastiaansen J., Nguyen N.T., Dekkers J.C.M., Plastow G.S., Rothshild M.F. (2004b): Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions. Obesity Research, 12,1981-1994.
11. Matteri R.L. (2001): Overview of central targets for appetite regulation. Journal of Animal Science, 79,148-158.
12. Meidtner K., Wermter A.K., Hinney A., Remschmidt H., Hebebrand J., Fries R. (2006): Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs. Animal Genetics, 37, 245-247.
13. Ovilo C., Fernández A., Rodríguez M.C., Nieto M., Silió L. (2006): Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs. Meat Science, 73, 42-47.
14. Park H.B., Carlborg Ö., Marklund S., Andersson L. (2002): Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Animal Genetics, 33,155-157.
15. SAS (2001): SAS̄ Propriety Software Release 9.1 of the SAS̄ system for Microsoft̄Windows̄SAS Institute Inc., Cary, USA.
16. Stachowiak M., Szydlowski M., Obarzanek-Fojt M., Switonski M. (2005): An effect of a missense mutation in the porcine melanocortin-4 receptor (MC4R) gene on production traits in Polish pig breeds is doubtful. Animal Genetics, 37, 55-57.
17. Stupka R., Šprysl M., Pour M. (2004): Analysis of the formation of the belly in relation to sex. Czech Journal of Animal Science, 49, 64-70.
18. Van den Maagdenberg K., Stinckens A., Claeys E., Seynaeve M., Clinquart A., Georges M., Buys N., De Smet S. (2007): The Asp298Asn missense mutation in the porcine melanocortin-4 receptor (MC4R) gene can be used to affect growth and carcass traits without an effect on meat quality. Animal, 1,1089-1098.
19. Walstra P., Merkus G.S.M. (1995): Procedure for assessment of the lean meat percentage as a consequence of the new EU reference dissection method in pig carcass classification. DLO- Research Institute for Animal Science and Health Research Branch, Zeist, The Netherlands, 1-22.