Complement C3 serum levels in anorexia nervosa: A potential biomarker for the severity of disease?

Annals of General Psychiatry

Volumn 10, Issue , 2011, Pages

  Flierl, Michael A ^a   Gaudiani, Jennifer L ^a   Sabel, Allison L ^a   Long, Carlin S ^a   Stahel, Philip F ^a,b   Mehler, Philip S ^a  

^a DENVER HEALTH MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; COMPLEMENT MEMBRANE ATTACK COMPLEX;

ADULT; ANOREXIA NERVOSA; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; COMPLEMENT HEMOLYSIS TEST; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HOSPITAL DISCHARGE; HUMAN; MALE; PROSPECTIVE STUDY; REFERENCE VALUE; RISK FACTOR; SIGNAL TRANSDUCTION;

EID: 79955497709     PISSN: None     EISSN: 1744859X     Source Type: Journal    
DOI: 10.1186/1744-859X-10-16     Document Type: Article

References (30)

1. Hudson JI, Hiripi E, Pope HG, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry 2007, 61:348-358. 10.1016/j.biopsych.2006.03.040, 1892232, 16815322.
2. Mehler PS, Krantz M. Anorexia nervosa medical issues. J Womens Health 2003, 12:331-340.
3. Steinhausen HC. The outcome of anorexia nervosa in the 20th century. Am J Psychiatry 2002, 159:1284-1293. 10.1176/appi.ajp.159.8.1284, 12153817.
4. Mehler PS, Winkleman AB, Andersen DM, Gaudiani JL. Nutritional rehabilitation: practical guidelines for refeeding the anorectic patient. J Nutr Metab 2010, pii:625782.
5. Schwartz BI, Mansbach JM, Marion JG, Katzman DK, Forman SF. Variations in admission practices for adolescents with anorexia nervosa: a North American sample. J Adolesc Health 2008, 43:425-431. 10.1016/j.jadohealth.2008.04.010, 18848669.
6. Krantz MJ, Lee D, Donahoo WT, Mehler PS. The paradox of normal serum albumin in anorexia nervosa: a case report. Int J Eat Disord 2005, 37:278-280. 10.1002/eat.20129, 15822081.
7. Narayanan V, Gaudiani JL, Mehler PS. Serum albumin levels may not correlate with weight status in severe anorexia nervosa. Eat Disord 2009, 17:322-326. 10.1080/10640260902991202, 19548148.
8. Gaudiani J, Sabel AL, Mascolo M, Mehler PS. Severe anorexia nervosa: Outcomes from a medical stabilization unit. Int J Eat Disord
9. Mehler PS, Weiner KL. Use of total parenteral nutrition in the refeeding of selected patients with severe anorexia nervosa. Int J Eat Disord 2007, 40:285-287. 10.1002/eat.20371, 17262814.
10. Narayanan V, Gaudiani J, Harris RH, Mehler PS. Liver function test abnormalities in anorexia nervosa - cause or effect. Int J Eat Disord 2010, 43:378-381.
11. Mehler PS, MacKenzie TD. Treatment of osteopenia and osteoporosis in anrexia nervosa: a systematic review of the literature. Int J Eat Disord 2009, 42:195-201. 10.1002/eat.20593, 18951456.
12. Prince AC, Brooks SJ, Stahl D, Treasure J. Systematic review and meta-analysis of the baseline concentrations and physiologic responses of gut hormones to food in eating disorders. Am J Clin Nutr 2009, 89:755-765. 10.3945/ajcn.2008.27056, 19176730.
13. Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 2006, 12:682-687. 10.1038/nm1419, 16715088.
14. Stahel PF, Barnum SR. The role of the complement system in CNS inflammatory diseases. Expert Rev Clin Immunol 2006, 2:445-456. 10.1586/1744666X.2.3.445, 20476915.
15. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008, 8:776-787. 10.1038/nri2402, 2786961, 18802444.
16. Schreiber H, Rittirsch D, Flierl M, Brueckner U, Schneider M, Weiss M, Gebhard F, Huber-Lang M. Complement activation during sepsis in humans. Adv Exp Med Biol 2006, 586:217-226. 10.1007/0-387-34134-X_15, 16893075.
17. Gaudiani JL, Kashuk JL, Chu ES, Narayanan V, Mehler PS. The use of thrombelastography to determine coagulation status in severe anorexia nervosa: a case series. Int J Eat Disord 2010, 43:382-385.
18. Cleary BS, Gaudiani JL, Mehler PS. Interpreting the complete blood count in anorexia nervosa. Eat Disord 2010, 18:132-139. 10.1080/10640260903585540, 20390616.
19. Huber-Lang M, Younkin EM, Sarma JV, Riedemann N, McGuire SR, Lu KT, Kunkel R, Younger JG, Zetoune FS, Ward PA. Generation of C5a by phagocytic cells. Am J Pathol 2002, 161:1849-1859. 10.1016/S0002-9440(10)64461-6, 1850785, 12414531.
20. Monteleone P, Di Lieto A, Martiadis V, Pannuto M, Maj M. Altered immunoreactive levels of G proteins in peripheral mononuclear cells of patients with anorexia nervosa and bulimia nervosa. Mol Psychiatry 2003, 8:680-684. 10.1038/sj.mp.4001304, 12874604.
21. Palmblad J, Fohlin L, Norberg R. Plasma levels of complement factors 3 and 4, orosomucoid and opsonic functions in anorexia nervosa. Acta Paediatr Scand 1979, 68:617-618. 10.1111/j.1651-2227.1979.tb05067.x, 463547.
22. Wyatt RJ, Farrell M, Berry PL, Forristal J, Maloney MJ, West CD. Reduced alternative complement pathway control protein levels in anorexia nervosa: response to parenteral alimentation. Am J Clin Nutr 1982, 35:973-980.
23. Sigal LH, Snyder BK. Low serum complement levels in anorexia nervosa. Am J Dis Child 1989, 143:1391-1392.
24. Pomeroy C, Mitchell J, Eckert E, Raymond N, Crosby R, Dalmasso AP. Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity. Clin Exp Immunol 1997, 108:507-515. 10.1046/j.1365-2249.1997.3921287.x, 1904692, 9182900.
25. Nova E, Lopez-Vidriero I, Varela P, Toro O, Casas JJ, Marcos AA. Indicators of nutritional status in restricting-type anorexia nervosa patients: a 1-year follow-up study. Clin Nutr 2004, 23:1353-1359.
26. Flierl MA, Stahel PF, Rittirsch D, Huber-Lang M, Niederbichler AD, Hoesel LM, Touban BM, Morgan SJ, Smith WR, Ward PA, Ipaktchi K. Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. Crit Care 2009, 13:R12. 10.1186/cc7710, 2688129, 19196477.
27. Czermak BJ, Sarma V, Pierson CL, Warner RL, Huber-Lang M, Bless NM, Schmal H, Friedl HP, Ward PA. Protective effects of C5a blockade in sepsis. Nat Med 1999, 5:788-792. 10.1038/10512, 10395324.
28. Leinhase I, Schmidt OI, Thurman JM, Hossini AM, Rozanski M, Taha ME, Scheffler A, John T, Smith WR, Holers VM, Stahel PF. Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Exp Neurol 2006, 199:454-464. 10.1016/j.expneurol.2006.01.033, 16545803.
29. Flierl MA, Perl M, Rittirsch D, Bartl C, Schreiber H, Fleig V, Schlaf G, Liener U, Brueckner UB, Gebhard F, Huber-Lang MS. The role of C5a in the innate immune response after experimental blunt chest trauma. Shock 2008, 29:25-31.
30. Riedemann NC, Ward PA. Complement in ischemia reperfusion injury. Am J Pathol 2003, 162:363-367. 10.1016/S0002-9440(10)63830-8, 1851148, 12547694.