The Mu Opioid Receptor Is Not Involved in Ethanol-Stimulated Dopamine Release in the Ventral Striatum of C57BL/6J Mice

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 5, 2011, Pages 929-938

  Ramachandra, Vorani ^a   Kang, Francis ^a   Kim, Christine ^a   Nova, Alan S ^a   Bajaj, Ankur ^a   Scott Hall, F ^b   Uhl, George R ^a   Gonzales, Rueben A ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Beta funaltrexamine; C57BL 6J mice; Dopamine; Microdialysis; MOR

Indexed keywords

ALCOHOL; BETA FUNALTREXAMINE; DOPAMINE; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; C57BL 6 MOUSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; FEMALE; GENOTYPE; KNOCKOUT MOUSE; LIMBIC SYSTEM; MALE; MICRODIALYSIS; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; PHARMACOLOGICAL BLOCKING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; BASAL GANGLIA; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; MALE; MICE; MICE, 129 STRAIN; MICE, CONGENIC; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, OPIOID, MU;

MUS;

EID: 79955484012     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01423.x     Document Type: Article

References (46)

1. Blanchard BA, Steindorf S, Wang S, Glick SD (1993) Sex differences in ethanol-induced dopamine release in nucleus accumbens and in ethanol consumption in rats. Alcohol Clin Exp Res 17:968-973.
2. Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005) Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcohol Clin Exp Res 29:1949-1958.
3. Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA (2010) Hybrid mice as genetic models of high alcohol consumption. Behav Genet 40:93-110.
4. Chefer VI, Denoroy L, Zapata A, Shippenberg TS (2009) Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms. Eur J Neurosci 30:272-278.
5. Cooney CA, Dave AA, Wolff GL (2002) Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132:2393-2400.
6. Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF (2006) Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol 11:195-269.
7. Deb I, Chakraborty J, Gangopadhyay PK, Choudhury SR, Das S (2010) Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J Neurochem 112:486-496.
8. Doyon WM, York JL, Diaz LM, Samson HH, Czachowski CL, Gonzales RA (2003) Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self-administration. Alcohol Clin Exp Res 27:1573-1582.
9. Drgonova J, Zimonjic DB, Hall FS, Uhl GR (2010) Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Neuroscience 165:882-895.
10. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181.
11. Gonzales RA, Job MO, Doyon WM (2004) The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol Ther 103:121-146.
12. Gonzales RA, Weiss F (1998) Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci 18:10663-10671.
13. Hall FS, Li XF, Goeb M, Roff S, Hoggatt H, Sora I, Uhl GR (2003) Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects. Genes Brain Behav 2:114-121.
14. Hall FS, Sora I, Ugl GR (2001) Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice. Psychopharmacology (Berl) 154:43-49.
15. Hodge CW, Samson HH, Haraguchi M (1992) Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding. Pharmacol Biochem Behav 43:249-254.
16. Howard EC, Schier CJ, Wetzel JS, Duvauchelle CL, Gonzales RA (2008) The shell of the nucleus accumbens has a higher dopamine response compared with the core after non-contingent intravenous ethanol administration. Neuroscience 154:1042-1053.
17. Howard EC, Schier CJ, Wetzel JS, Gonzales RA (2009) The dopamine response in the nucleus accumbens core-shell border differs from that in the core and shell during operant ethanol self-administration. Alcohol Clin Exp Res 33:1355-1365.
18. Job MO, Tang A, Hall FS, Sora I, Uhl GR, Bergeson SE, Gonzales RA (2007) Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry 62:627-634.
19. Johnson C, Drgon T, Liu QR, Walther D, Edenberg H, Rice J, Foroud T, Uhl GR (2006) Pooled association genome scanning for alcohol dependence using 104, 268 SNPs: validation and use to identity alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. Am J Med Genet B Neuropsychiatr Genet 141B:844-853.
20. Kamdar NK, Miller SA, Syed YM, Bhayana R, Gupta T, Rhodes JS (2007) Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice. Psychopharmacology (Berl) 192:207-217.
21. Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC (1998) Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav 59:627-635.
22. Middaugh LD, Kelley BM, Cuison ER Jr, Groseclose CH (1999) Naltrexone effects on ethanol reward and discrimination in C57BL/6 mice. Alcohol Clin Exp Res 23:456-464.
23. Middaugh LD, Szumlinski KK, Van Patten Y, Marlowe AL, Kalivas PW (2003) Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone. Alcohol Clin Exp Res 27:1892-1900.
24. Narita M, Imai S, Itou Y, Yajima Y, Suzuki T (2002) Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites. Life Sci 70:2341-2354.
25. Oroszi G, Anton RF, O'Malley S, Swift R, Pettinati H, Couper D, Yuan Q, Goldman D (2009) OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res 33:383-393.
26. Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK (2010) A method for mapping intralocus interactions influencing excessive alcohol drinking. Mamm Genome 21:39-51.
27. Phillips TJ, Wenger CD, Dorow JD (1997) Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcohol Clin Exp Res 21:691-702.
28. Pick CG, Paul D, Pasternak GW (1991) Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions. Life Sci 48:2005-2011.
29. Pierce RC, Kumaresan V (2006) The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 30:215-238.
30. Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE (1980) A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. J Med Chem 23:233-234.
31. Rada P, Barson JR, Leibowitz SF, Hoebel BG (2010) Opioids in the hypothalamus control dopamine and acetylcholine levels in the nucleus accumbens. Brain Res 1312:1-9.
32. Ramachandra V, Phuc S, Franco AC, Gonzales RA (2007) Ethanol preference is inversely correlated with ethanol-induced dopamine release in 2 substrains of C57BL/6 mice. Alcohol Clin Exp Res 31:1669-1676.
33. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M (2010) A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry (in press).
34. Risinger FO, Freeman PA, Rubinstein M, Low MJ, Grandy DK (2000) Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology (Berl) 152:343-350.
35. Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HW, Koob GF, Gold LH (2000) mu-Opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Ther 293:1002-1008.
36. Samson HH, Hodge CW, Tolliver GA, Haraguchi M (1992) Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens. Brain Res Bull 30:133-141.
37. Tanda G, Di Chiara G (1998) A dopamine-mu1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse. Eur J Neurosci 10:1179-1187.
38. Tang A, George MA, Randall JA, Gonzales RA (2003) Ethanol increases extracellular dopamine concentration in the ventral striatum in C57BL/6 mice. Alcohol Clin Exp Res 27:1083-1089.
39. Uhl GR, Drgon T, Johnson C, Liu QR (2009) Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. J Neurogenet 23:272-282.
40. Ward SJ, Fries DS, Larson DL, Portoghese PS, Takemori AE (1985) Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA). Eur J Pharmacol 107:323-330.
41. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, Tahiliani KG (2006) Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis 44:401-406.
42. Waterland RA, Jirtle RL (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23:5293-5300.
43. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258.
44. Weiss F, Porrino LJ (2002) Behavioral neurobiology of alcohol addiction: recent advances and challenges. J Neurosci 22:3332-3337.
45. Whitelaw NC, Whitelaw E (2006) How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15:R131-R137.
46. Yim HJ, Robinson DL, White ML, Jaworski JN, Randall PK, Lancaster FE, Gonzales RA (2000) Dissociation between the time course of ethanol and extracellular dopamine concentrations in the nucleus accumbens after a single intraperitoneal injection. Alcohol Clin Exp Res 24:781-788.