Analysis of cortisol, cortisone and dexamethasone in human serum using liquid chromatography tandem mass spectrometry and assessment of cortisol: Cortisone ratios in patients with impaired kidney function

Clinica Chimica Acta

Volumn 412, Issue 13-14, 2011, Pages 1221-1228

  Ray, Julie A ^a,c   Kushnir, Mark M ^a,c   Rockwood, Alan L ^a,b,c   Meikle, A Wayne ^a,b,c  

^a ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c ARUP LABORATORIES   (United States)

Author keywords

11 hydroxysteroid dehydrogenase; Cortisol; Cortisone; Cushing's syndrome; Dexamethasone; LC MS MS

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; DEXAMETHASONE; HYDROCORTISONE;

ACCURACY; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CRITICALLY ILL PATIENT; CUSHING SYNDROME; DRUG BLOOD LEVEL; ENZYME ACTIVITY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; INTENSIVE CARE UNIT; KIDNEY DYSFUNCTION; LIQUID CHROMATOGRAPHY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; AGED; CHROMATOGRAPHY, LIQUID; CORTISONE; CUSHING SYNDROME; DEXAMETHASONE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYDROCORTISONE; INTENSIVE CARE UNITS; KIDNEY DISEASES; MALE; MIDDLE AGED; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 79955478950     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2011.03.016     Document Type: Article

References (54)

1. Buske-Kirschbaum A. Cortisol responses to stress in allergic children: interaction with the immune response. Neuroimmunomodulation 2009, 16:325-332.
2. den Brinker M., Joosten K.F., Liem O., de Jong F.H., Hop W.C., Hazelzet J.A., et al. Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab 2005, 90:5110-5117.
3. Scarfone R.J., Friedlaender E. Corticosteroids in acute asthma: past, present, and future. Pediatr Emerg Care 2003, 19:355-361.
4. Rhen T., Cidlowski J.A. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005, 353:1711-1723.
5. Reynolds R.M., Walker B.R., Haw S., Newby D.E., Mackay D.F., Cobbe S.M., et al. Low serum cortisol predicts early death after acute myocardial infarction. Crit Care Med 2010, 38:973-975.
6. Kroll J. Correlations of plasma cortisol levels, chaperone expression and mammalian longevity: a review of published data. Biogerontology 2010, 11:495-499.
7. Reynolds R.M., Strachan M.W., Labad J., Lee A.J., Frier B.M., Fowkes F.G., et al. Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care 2010, 33:714-720.
8. Dodt C., Wellhoner J.P., Schutt M., Sayk F. Glucocorticoids and hypertension. Internist (Berl) 2009, 50:36-41.
9. Ferrari P. The role of 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension. Biochim Biophys Acta 2009, 1802:1178-1187.
10. Naruse M., Tanabe A., Tsuiki M. Concept and clinical significance of subclinical Cushing syndrome. Rinsho Byori 2010, 58:232-237.
11. Holst J.P., Soldin S.J., Tractenberg R.E., Guo T., Kundra P., Verbalis J.G., et al. Use of steroid profiles in determining the cause of adrenal insufficiency. Steroids 2007, 72:71-84.
12. Riedel M., Wiese A., Schurmeyer T.H., Brabant G. Quality of life in patients with Addison's disease: effects of different cortisol replacement modes. Exp Clin Endocrinol 1993, 101:106-111.
13. Lovas K., Thorsen T.E., Husebye E.S. Saliva cortisol measurement: simple and reliable assessment of the glucocorticoid replacement therapy in Addison's disease. J Endocrinol Invest 2006, 29:727-731.
14. Terzidis K., Panoutsopoulos A., Mantzou A., Tourli P., Papageorgiou G., Saltiki K., et al. Lower early morning plasma cortisol levels are associated with thyroid autoimmunity in the elderly. Eur J Endocrinol 2010, 162:307-313.
15. Hochberg Z., Friedberg M., Yaniv L., Bader T., Tiosano D. Hypothalamic regulation of adiposity: the role of 11beta-hydroxysteroid dehydrogenase type 1. Horm Metab Res 2004, 36:365-369.
16. Benediktsson R., Edwards C.R. Apparent mineralocorticoid excess. J Hum Hypertens 1994, 8:371-375.
17. Tedde R., Pala A., Melis A., Ulick S. Evidence for cortisol as the mineralocorticoid in the syndrome of apparent mineralocorticoid excess. J Endocrinol Invest 1992, 15:471-474.
18. Pant P., Nadimpalli L., Singh M., Cheng J.C. A case of severe hypokalemic paralysis and hypertension. Licorice-induced hypokalemic paralysis. Am J Kidney Dis 2010, 55:A35-A37.
19. Ness-Abramof R., Nabriski D., Apovian C.M., Niven M., Weiss E., Shapiro M.S., et al. Overnight dexamethasone suppression test: a reliable screen for Cushing's syndrome in the obese. Obes Res 2002, 10:1217-1221.
20. Castro M., Elias L.L., Elias P.C., Moreira A.C. A dose-response study of salivary cortisol after dexamethasone suppression test in Cushing's disease and its potential use in the differential diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 2003, 59:800-805.
21. Martin N.M., Dhillo W.S., Banerjee A., Abdulali A., Jayasena C.N., Donaldson M., et al. Comparison of the dexamethasone-suppressed corticotropin-releasing hormone test and low-dose dexamethasone suppression test in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 2006, 91:2582-2586.
22. Reimondo G., Bovio S., Allasino B., De Francia S., Zaggia B., Micossi I., et al. The combined low-dose dexamethasone suppression corticotropin-releasing hormone test as a tool to rule out Cushing's syndrome. Eur J Endocrinol 2008, 159:569-576.
23. Meikle A.W. Dexamethasone suppression tests: usefulness of simultaneous measurement of plasma cortisol and dexamethasone. Clin Endocrinol (Oxf) 1982, 16:401-408.
24. Holder G. Measurement of glucocorticoids in biological fluids. Methods Mol Biol 2006, 324:141-157.
25. Kennedy D.M., Selby C., Lawson N. Measurement of urinary free cortisol using the Acs:180 serum cortisol chemiluminescent immunoassay. Ann Clin Biochem 2000, 37(Pt 4):520-528.
26. Murphy B.E. How much "UFC" is really cortisol?. Clin Chem 2000, 46:793-794.
27. Delahaut P., Jacquemin P., Colemonts Y., Dubois M., De Graeve J., Deluyker H. Quantitative determination of several synthetic corticosteroids by gas chromatography-mass spectrometry after purification by immunoaffinity chromatography. J Chromatogr B Biomed Sci Appl 1997, 696:203-215.
28. Bagnati R., Ramazza V., Zucchi M., Simonella A., Leone F., Bellini A., et al. Analysis of dexamethasone and betamethasone in bovine urine by purification with an "on-line" immunoaffinity chromatography-high-performance liquid chromatography system and determination by gas chromatography-mass spectrometry. Anal Biochem 1996, 235:119-126.
29. Shibata N., Hayakawa T., Takada K., Hoshino N., Minouchi T., Yamaji A. Simultaneous determination of glucocorticoids in plasma or urine by high-performance liquid chromatography with precolumn fluorimetric derivatization by 9-anthroyl nitrile. J Chromatogr B Biomed Sci Appl 1998, 706:191-199.
30. Persichilli S., Gervasoni J., Iavarone F., Zuppi C. A simple liquid chromatography-tandem mass spectrometry method for urinary free cortisol analysis: suitable for routine purpose. Clin Chem Lab Med 2010, 48:1433-1437.
31. Kao P.C., Machacek D.A., Magera M.J., Lacey J.M., Rinaldo P. Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry. Ann Clin Lab Sci 2001, 31:199-204.
32. Volmer D.A., Hui J.P. Rapid determination of corticosteroids in urine by combined solid phase microextraction/liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 1997, 11:1926-1933.
33. Jonsson B.A., Malmberg B., Amilon A., Helene Garde A., Orbaek P. Determination of cortisol in human saliva using liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003, 784:63-68.
34. Ceglarek U., Kortz L., Leichtle A., Fiedler G.M., Kratzsch J., Thiery J. Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Clin Chim Acta 2009, 401:114-118.
35. Frerichs V.A., Tornatore K.M. Determination of the glucocorticoids prednisone, prednisolone, dexamethasone, and cortisol in human serum using liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2004, 802:329-338.
36. Difrancesco R., Frerichs V., Donnelly J., Hagler C., Hochreiter J., Tornatore K.M. Simultaneous determination of cortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, mycophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007, 859:42-51.
37. Kushnir M.M., Neilson R., Roberts W.L., Rockwood A.L. Cortisol and cortisone analysis in serum and plasma by atmospheric pressure photoionization tandem mass spectrometry. Clin Biochem 2004, 37:357-362.
38. Ionita I.A., Fast D.M., Akhlaghi F. Development of a sensitive and selective method for the quantitative analysis of cortisol, cortisone, prednisolone and prednisone in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877:765-772.
39. Vogeser M., Zachoval R., Felbinger T.W., Jacob K. Increased ratio of serum cortisol to cortisone in acute-phase response. Horm Res 2002, 58:172-175.
40. Vogeser M., Groetzner J., Kupper C., Briegel J. The serum cortisol:cortisone ratio in the postoperative acute-phase response. Horm Res 2003, 59:293-296.
41. Goodman S., Sprung C.L., Ziegler D., Weiss Y.G. Cortisol changes among patients with septic shock and the relationship to ICU and hospital stay. Intensive Care Med 2005, 31:1362-1369.
42. Taylor R.L., Machacek D., Singh R.J. Validation of a high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and cortisone. Clin Chem 2002, 48:1511-1519.
43. Annesley T.M. Ion suppression in mass spectrometry. Clin Chem 2003, 49:1041-1044.
44. Wood L., Ducroq D.H., Fraser H.L., Gillingwater S., Evans C., Pickett A.J., et al. Measurement of urinary free cortisol by tandem mass spectrometry and comparison with results obtained by gas chromatography-mass spectrometry and two commercial immunoassays. Ann Clin Biochem 2008, 45:380-388.
45. Tang C., Kassahun K., McIntosh I.S., Brunner J., Rodrigues A.D. Simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry and its application for estimating hepatic CYP3A induction. J Chromatogr B Biomed Sci Appl 2000, 742:303-313.
46. Kushnir M.M., Rockwood A.L., Roberts W.L., Pattison E.G., Bunker A.M., Fitzgerald R.L., et al. Performance characteristics of a novel tandem mass spectrometry assay for serum testosterone. Clin Chem 2006, 52:120-128.
47. Kushnir M.M., Rockwood A.L., Nelson G.J., Yue B., Urry F.M. Assessing analytical specificity in quantitative analysis using tandem mass spectrometry. Clin Biochem 2005, 38:319-327.
48. Kerstens M.N., Dullaart R.P. 11 beta-hydroxysteroid-dehydrogenase: characteristics and the clinical significance of a key enzyme in cortisol metabolism. Ned Tijdschr Geneeskd 1999, 143:509-514.
49. Hamrahian A.H., Oseni T.S., Arafah B.M. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004, 350:1629-1638.
50. Morineau G., Boudi A., Barka A., Gourmelen M., Degeilh F., Hardy N., et al. Radioimmunoassay of cortisone in serum, urine, and saliva to assess the status of the cortisol-cortisone shuttle. Clin Chem 1997, 43:1397-1407.
51. Baker R.W., Walker B.R., Shaw R.J., Honour J.W., Jessop D.S., Lightman S.L., et al. Increased cortisol: cortisone ratio in acute pulmonary tuberculosis. Am J Respir Crit Care Med 2000, 162:1641-1647.
52. Colao A., Pivonello R., Spiezia S., Faggiano A., Ferone D., Filippella M., et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J Clin Endocrinol Metab 1999, 84:2664-2672.
53. Beauregard C., Dickstein G., Lacroix A. Classic and recent etiologies of Cushing's syndrome: diagnosis and therapy. Treat Endocrinol 2002, 1:79-94.
54. Meikle A.W., Lagerquist L.G., Tyler F.H. Apparently normal pituitary-adrenal suppressibility in Cushing's syndrome: dexamethasone metabolism and plasma levels. J Lab Clin Med 1975, 86:472-478.