Corticosteroids in Acute Asthma: Past, Present, and Future

Pediatric Emergency Care

Volumn 19, Issue 5, 2003, Pages 355-362

  Scarfone, Richard J ^a,b   Friedlaender, Eron ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Asthma; Corticosteroids; Emergency department

Indexed keywords

BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BISULFITE; BUDESONIDE; CORTICOSTEROID; DEXAMETHASONE ACETATE; DEXAMETHASONE SODIUM PHOSPHATE; FLUNISOLIDE; FLUTICASONE; FLUTICASONE PROPIONATE; METHYLPREDNISOLONE; ORAPRED; PREDNISOLONE; PREDNISONE; SALBUTAMOL; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHOSPASM; CLINICAL TRIAL; DRUG CHOICE; DRUG FORMULATION; DRUG MECHANISM; DRUG TOLERABILITY; GROWTH RETARDATION; HISTORY OF MEDICINE; HUMAN; IMMUNE DEFICIENCY; LONG TERM CARE; METERED DOSE INHALER; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; PRACTICE GUIDELINE; REVIEW; SIDE EFFECT; STEROID THERAPY; TABLET;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ADOLESCENT; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS; DEXAMETHASONE; EMERGENCIES; FORECASTING; HUMANS; INFANT; PRACTICE GUIDELINES; PREDNISONE; RECURRENCE;

EID: 0142188600     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pec.0000092585.40174.f6     Document Type: Review

References (46)

1. Barnes P. Drug therapy: inhaled glucocorticoids for asthma. N Engl J Med. 1995;332:868-875.
2. Gibbs M, Camargo C, Rowe B, et al. State of the art: therapeutic controversies in severe acute asthma. Acad Emerg Med. 2000;7:800-815.
3. Medical Research Council. Controlled trial of effects of cortisone acetate in chronic asthma. Lancet. 1956;2:798-803.
4. Medical Research Council. Controlled trial of effects of cortisone acetate in status asthmaticus. Lancet. 1956;2:803-806.
5. Younger RE, Gerber PS, Herrod HG, et al. Intravenous methylprednisolone efficacy in status asthmaticus of childhood. Pediatrics. 1987;80:225-230.
6. Fanta CH, Rossing TH, McFadden ER. Glucocorticoids in acute asthma: a critical controlled trial. Am J Med. 1983;74:845-851.
7. Gleeson JGA, Loftus BG, Prince JF. Placebo controlled trial of systemic corticosteroids in acute childhood asthma. Acta Paediatr Scand. 1990;79:1052-1058.
8. Harris JB, Weinberger MM, Nassif E, et al. Early intervention with short courses of prednisone to prevent progression of asthma in ambulatory patients incompletely responsive to bronchodilators. J Pediatr. 1987;110:627-633.
9. Deshpande A, McKenzie SA. Short course of steroids in home treatment of children with acute asthma. Br Med J. 1986;293:169-171.
10. Shapiro GG, Furukawa CT, Pierson WE, et al. Double-blind evaluation of methylprednisolone versus placebo for acute asthma episodes. Pediatrics. 1983;71:510-514.
11. Brunette MG, Lands L, Thibodeau LP. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection. Pediatrics. 1988;81:624-628.
12. Pierson WE, Bierman CW, Kelley VC. A double-blind trial of corticosteroid therapy in status asthmaticus. Pediatrics. 1974;54:282-288.
13. Laurens Jr RG, Honig EG. Corticosteroids in the treatment of asthma. Southern Med J. 1986;79:1544-1552.
14. Canny GJ, Reisman J, Healy R, et al. Acute asthma: observations regarding the management of a pediatric emergency room. Pediatrics. 1989;83:507-512.
15. Littenberg B, Gluck EH. A controlled trial of methylprednisolone in the emergency treatment of acute asthma. N Engl J Med. 1986;314:150-152.
16. Tal A, et al. Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial. Pediatrics. 1990;86:350-356.
17. Scarfone RJ, Fuchs SM, Nager AL, et al. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics. 1993;92:513-518.
18. National Asthma Education and Prevention Program. Expert Panel Report 2. Guidelines for the Diagnosis and Management of Asthma (report no. 97-4051). Bethesda, MD: National Institutes of Health: National Heart, Lung, and Blood Institute; 1997.
19. Barnett PJL, et al. Intravenous vs. oral corticosteroids in the management of acute asthma in children. Ann Emerg Med. 1997;29(2):212-217.
20. Schimmer BP, Parker KL. Adrenocortical steroids and their synthetic analogs. In: Hardman JG, Limbird LE, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. New York: McGraw-Hill; 1996:1459-1485.
21. Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139:20-26.
22. Adams RJ, Fuhlbrigge A, Finkelstein JA, et al. Impact of inhaled anti-inflammatory therapy on hospitalization and emergency department visits for children with asthma. Pediatrics. 2001;107:706-711.
23. Suissa S, Ernst P, Benayoun S, et al. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med. 2000;343:332-336.
24. Szefler S, Weiss S, Tonascia J, et al. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med. 2000;343(15): 1054-1063.
25. Peden DB, Berger WE, Noonan MJ, et al. Inhaled fluticasone propionate delivered by means of two different multidose powder inhalers is effective and safe in a large pediatric population with persistent asthma. J Allergy Clin Immunol. 1998;102:32-38.
26. Edmunds ML, Camargo Jr CA, Pollack Jr CV, et al. The effectiveness of inhaled corticosteroids in the emergency department treatment of acute asthma: a meta-analysis. Ann Emerg Med. 2002;40:145-154.
27. Scarfone RJ, Loiselle JM, Wiley II JF, et al. Nebulized dexamethasone vs. oral prednisone in the emergency department treatment of acute asthma in children. Ann Emerg Med. 1995;26:480-486.
28. Devidayal, Singhi DS, Kumar L, et al. Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma. Acta Pediatr. 1999;88:835-840.
29. Schuh S, Reisman J, Alshehri M, et al. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med. 2000;343:689-694.
30. Pederson S, Steffensen G, Ekman I, et al. Pharmacokinetics of budesonide in children with asthma. Eur J Clin Pharmacol. 1987;31:579-582.
31. Lodrup Carlson KC, Nikander K, Carlsen KH. How much nebulized budesonide reached infants and toddlers. Arch Dis Child. 1991;67:1077-1079.
32. Scarfone RJ, Friedlaender EY. β-agonists in acute asthma: the evolving state of the art. Pediatr Emerg Care. 2002;18:442-448.
33. Kelsen S, Kelsen D, Fleegler B, et al. Emergency room assessment and treatment of patients with acute asthma: adequacy of the conventional approach. Am J Med. 1978;64:622-628.
34. Fischl M, Pitchenik A, Gardner L. An index predicting relapse and need for hospitalization in patients with acute bronchial asthma. N Engl J Med. 1981;305:783-789.
35. Rose C, Murphy J, Schwartz J. Performance of an index predicting the response of patients with acute bronchial asthma to intensive emergency department treatment. N Engl J Med. 1984;310:573-577.
36. Chapman K, Verbeek P, White J, et al. Effect of a short course of prednisone in the prevention of early relapse after the emergency room treatment of acute asthma. N Engl J Med. 1991;324:788-794.
37. McNamara R, Rubin J. Intramuscular methylprednisolone acetate for the prevention of relapse in acute asthma. Ann Emerg Med. 1993;22:53-59.
38. Gries D, Moffitt D, Pulos E, et al. A single dose of intramuscularly administered dexamethasone acetate is as effective as oral prednisone to treat asthma exacerbations in young children. J Pediatr. 2000;136:298-303.
39. Brenner B, Chavda K, Camargo C. Randomized trial of inhaled flunisolide versus placebo among asthmatic patients discharged from the emergency department. Ann Emerg Med. 2000;36:417-425.
40. Rowe B, Bota G, Fabris L, et al. Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department. JAMA. 1999;281:2119-2126.
41. Rowe BH, Edmonds ML. Inhaled corticosteroids for acute asthma after emergency department discharge. Ann Emerg Med. 2000;36:477-480.
42. Sin D, Man S. Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch Intern Med. 2002;162:1591-1595.
43. Volovitz B, Bentur L, Finkelstein Y, et al. Effectiveness and safety of inhaled corticosteroids in controlling acute asthma attacks in children who were treated in the emergency department: a controlled comparative study with oral prednisolone. J Allergy Clin Immunol. 1999;102:605-609.
44. Edmonds M, Camargo C, Brenner B, et al. Replacement of oral corticosteroids with inhaled corticosteroids in the treatment of acute asthma following emergency department discharge. Chest. 2002;121:1798-1805.
45. Knorr B, Matz J, Bernstein J, et al. Montelukast for chronic asthma in 6 to 14-year-old children: a randomized, double-blind trail. JAMA. 1998;279(15):1181-1186.
46. Agertoft L, Pedersen S. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med. 2000;343:1064-1069.