Alcohol-Metabolizing Enzyme Gene Polymorphisms in the Basque Country, Morocco, and Ecuador

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 5, 2011, Pages 879-884

  Celorrio, David ^a   Bujanda, Luis ^a   Chbel, Faiza ^b   Sánchez, Dora ^c   Martinez Jarreta, Begoña ^d   De Pancorbo, Marian M ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b Laboratoire de Police Scientifique   (Morocco)

^c HOSPITAL METROPOLITANO   (Ecuador)

^d UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

ADH1B; ADH1C; Alcoholism; Basque country; Ecuador; Morocco; Polymorphism; Rs1229984; Rs1693482; Rs2066702; Rs698; SNP

Indexed keywords

ALCOHOL DEHYDROGENASE;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ECUADOR; ENZYME METABOLISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC ALGORITHM; GENETIC ASSOCIATION; GENETIC CODE; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MOROCCO; NORTH AFRICA; POPULATION GENETICS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ECUADOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; MOROCCO; POLYMORPHISM, SINGLE NUCLEOTIDE; SPAIN;

EID: 79955475199     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01418.x     Document Type: Article

References (32)

1. Borràs E, Coutelle C, Rosell A, Fernández-Muixi F, Broch M, Crosas B, Hjelmqvist L, Lorenzo A, Gutiérrez C, Santos M, Szczepanek M, Heilig M, Quattrocchi P, Farrés J, Vidal F, Richart C, Mach T, Bogdal J, Jörnvall H, Seitz HK, Couzigou P, Parés X (2000) Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH1B*2 allele decreases the risk for alcoholism and is associated with ADH1C*1. Hepatology 31:984-989.
2. Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ (1999) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65:795-807.
3. Crabb DW, Matsumoto M, Chang D, You M (2004) Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63:49-63.
4. Crabbe JC, Phillips TJ (2004) Pharmacogenetic studies of alcohol self-administration and withdrawal. Psychopharmacology (Berl) 174:539-560.
5. Edenberg HJ, Bosron WF (1997) Alcohol dehydrogenases, in Comprehensive Toxicology, Vol. 3, Biotransformation, Chapter 3.08 (Guengerich FP ed.), pp. 119-131. Pergamon Press, New York.
6. Enoch MA, Goldman D (2001) The genetics of alcoholism and alcohol abuse. Curr Psychiatry Rep 3:144-151.
7. Ericson M, Molander A, Löf E, Engel JA, Söderpalm B (2003) Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. Eur J Pharmacol 467:85-93.
8. Excoffier L, Laval G, Schneider S (2005) Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evol Bioinform Online 1:47-50.
9. Ferguson RA, Goldberg DM (1997) Genetic markers of alcohol abuse. Clin Chim Acta 257:199-250.
10. Fierro I, Ochoa R, Yáñez JL, Valderrama JC, Alvarez FJ (2008) Mortality related with alcohol in Spain and the different Autonomous Communities of Spain in 2004. Rev Clin Esp 208:455-462. Spanish.
11. Gorwood P (2000) Contribution of genetics to the concept of risk status for alcohol dependence. J Soc Biol 194:43-49. Review. French.
12. Han Y, Gu S, Oota H, Osier MV, Pakstis AJ, Speed WC, Kidd JR, Kidd KK (2007) Evidence of positive selection on a class I ADH locus. Am J Hum Genet 80:441-456.
13. Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, Chabrier A, Hung R, Hall J, Canzian F, Brennan P (2006) Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 15:696-703.
14. IKUSPEGI (2009) Immigrazioaren Euskal Behatokia-Observatorio Vasco de la Inmigración. Available at: Accessed October 14, 2009.
15. Lee SL, Höög JO, Yin SJ (2004) Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. Pharmacogenetics 14:725-732.
16. Li H, Gu S, Cai X, Speed WC, Pakstis AJ, Golub EI, Kidd JR, Kidd KK (2008) Ethnic related selection for an ADH Class I variant within East Asia. PLoS ONE 3:e1881.
17. Mulligan CJ, Robin RW, Osier MV, Sambuughin N, Goldfarb LG, Kittles RA, Hesselbrock D, Goldman D, Long JC (2003) Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet 113:325-336.
18. Neumark YD, Friedlander Y, Thomasson HR, Li TK (1998) Association of the ADH1B*2 allele with reduced ethanol consumption in Jewish men in Israel: a pilot study. J Stud Alcohol 59:133-139.
19. Osier MV, Cheung K-H, Kidd JR, Pakstis AJ, Miller PL, Kidd KK (2001) ALFRED: an allele frequency database for diverse populations and DNA polymorphisms-an update. Nucleic Acids Res 29:317-319.
20. Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK (2002a) A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. Alcohol Clin Exp Res 26:1759-1763.
21. Osier M, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB, Kidd KK (1999) Linkage disequilibrium at the ADH1B and ADH1C loci and risk of alcoholism. Am J Hum Genet 64:1147-1157.
22. Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi A, Okonofua F, Parnas J, Schulz LO, Bertranpetit J, Bonne-Tamir B, Lu RB, Kidd JR, Kidd KK (2002b) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 71:84-99.
23. Perego UA, Achilli A, Angerhofer N, Accetturo M, Pala M, Olivieri A, Kashani BH, Ritchie KH, Scozzari R, Kong QP, Myres NM, Salas A, Semino O, Bandelt HJ, Woodward SR, Torroni A (2009) Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups. Curr Biol 19:1-8.
24. Rao VR, Bhaskar LV, Annapurna C, Reddy AG, Thangaraj K, Rao AP, Singh L (2007) Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations. Am J Hum Biol 19:338-344.
25. Raymond M, Rousset F (1995) GENEPOP (version 4.0): population genetics software for exact tests and ecumenicism. J Hered 86:248-249.
26. Salcedo A (2007) Genetic aspects related to the alcoholism, Julio-diciembre, Volumen 3, Número 2. Boletín Electrónico de Salud Escolar, Tipica.
27. Schurr TG, Sherry ST (2004) Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidence. Am J Hum Biol 16:420-439.
28. Shen P, Lavi T, Kivisild T, Chou V, Sengun D, Gefel D, Shpirer I, Woolf E, Hillel J, Feldman MW, Oefner PJ (2004) Reconstruction of patrilineages and matrilineages of Samaritans and other Israeli populations from Y-chromosome and mitochondrial DNA sequence variation. Hum Mutat 24:248-260.
29. Vidal F, Lorenzo A, Auguet T, Olona M, Broch M, Gutiérrez C, Aguilar C, Estupiñà P, Santos M, Richart C (2004) Genetic polymorphisms of ADH1B, ADH1C, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. J Hepatol 41:744-750.
30. Ward RJ, McPherson AJ, Chow C, Ealing J, Sherman DI, Yoshida A, Peters TJ (1994) Identification and characterisation of alcohol-induced flushing in Caucasian subjects. Alcohol Alcohol 29:433-438.
31. Wolff PH (1972) Ethnic differences in alcohol sensitivity. Science 175:449-450.
32. Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (1988) Genotyping of human alcohol dehydrogenases at the ADH1B and ADH1C loci following DNA sequence amplification. Genomics 2:209-214.