Development of a nano-zirconia based 68Ge/68Ga generator for biomedical applications

Nuclear Medicine and Biology

Volumn 38, Issue 4, 2011, Pages 575-583

  Chakravarty, Rubel ^a   Shukla, Rakesh ^a   Ram, Ramu ^a   Tyagi, Avesh Kumar ^a   Dash, Ashutosh ^a   Venkatesh, Meera ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

68Ga radiopharmaceuticals; 68Ge 68Ga generator; DOTA TATE; Nano zirconia; PET imaging

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; GALLIUM 68; GERMANIUM; NANOZIRCONIA; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; BIOMEDICINE; CRYSTALLIZATION; EQUILIBRIUM CONSTANT; ISOTOPE LABELING; MOLECULAR STABILITY; PARTICLE SIZE; PURIFICATION; RADIATION DOSE; RADIOACTIVITY; RADIOCHEMISTRY; SYNTHESIS;

FEASIBILITY STUDIES; GALLIUM RADIOISOTOPES; GERMANIUM; ISOTOPE LABELING; NANOSTRUCTURES; QUALITY CONTROL; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; ZIRCONIUM;

EID: 79955470892     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.10.007     Document Type: Article

References (29)

1. Fani M., André J.P., Maecke H.R. 68Ga-PET: A powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals. Contrast Media Mol Imaging 2008, 3:53-63.
2. Firestone R. Table of Isotopes 1996, Wiley, New York. 8th ed.
3. Breeman W.A.P., Verbruggen A.M. The 68Ge/68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine?. Eur J Nucl Med Mol Imaging 2007, 34:978-981.
4. Rosch F., Knapp F.F. Radionuclide generators. Handbook of Nuclear Chemistry 2003, 81-118. Kluwer Academic Publishers, Dordrecht, The Netherlands. A. Vertes, S. Nagy, Z. Klencsar, F. Rosch (Eds.).
5. Roesch F., Riss P.J. The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry. Curr Top Med Chem 2010, 10:1633-1668.
6. Pagou M., Zerizer I., Al-Nahhas A. Can gallium-68 compounds partly replace 18F-FDG in PET molecular imaging?. Hellenic J Nucl Med 2009, 12:102-105.
7. Goldsmith S.J. Update on nuclear medicine imaging of neuroendocrine tumors. Future Oncol 2009, 5:75-84.
8. Smyth D., Al-Ejeh F., Tsopelas C., Brown M., Chatterton B. Molecular imaging with gallium-68 labelled biomolecules. ANZ Nucl Med 2009, 40:1.
9. Ambrosini V., Campana D., Tomassetti P., Grassetto G., Rubello D., Fanti S. PET/CT with 68Gallium-DOTA-peptides in NET: an overview. Eur J Radiol 2010, (In press).
10. Fellner M., Baum R.P., Kubícek V., Hermann P., Lukes I., Prasad V., et al. PET/CT imaging of osteoblastic bone metastases with 68Gabisphosphonates: first human study. Eur J Nucl Med Mol Imaging 2010, 37(4):834.
11. Ocak M., Antretter M., Knopp R., Kunkel F., Petrik M., Bergisadi N. Full automation of 68Ga labelling of DOTA-peptides including cation exchange prepurification. Appl Radiat Isot 2010, 68:297-302.
12. Asti M., De Pietri G., Fraternali A., Grassi E., Sghedoni R., Fioroni F. Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC. Nucl Med Biol 2008, 35:721-724.
13. Zhernosekov K.P., Filosofov D.V., Baum R.P., Aschoff P., Bihl H., Razbash A.A. Processing of generator-produced 68Ga for medical application. J Nucl Med 2007, 48:1741-1748.
14. Aardaneh K., Van Der Walt T.N. Ga2O for target, solvent extraction for radiochemical separation and SnO2 for the preparation of a 68Ge/68Ga generator. J Radioanal Nucl Chem 2006, 268:25-32.
15. McElvany K.D., Hopkins K.T., Welch M.J. Comparison of 68Ge/68Ga generator systems for radiopharmaceutical production. Int J Appl Radiat Isot 1984, 35:521-524.
16. Velikyan I., Beye G.J., Langström B. Microwave-supported preparation of 68Ga bioconjugates with high specific radioactivity. Bioconjugate Chem 2004, 15:554-560.
17. Meyer G.J., Maecke H., Schuhmacher J., Knapp W.H., Hofmann M. 68Ga-labelled DOTA-derivatised peptide ligands. Eur J Nucl Med Mol Imaging 2004, 31:1097-1104.
18. Chakravarty R., Shukla R., Ram R., Gandhi S., Dash A., Venkatesh M. Polymer embedded nanocrystalline titania sorbent for 99Mo-99mTc generator. J Nanosci Nanotechnol 2008, 8:4447-4452.
19. Chakravarty R., Dash A., Venkatesh M. Separation of clinical grade 188Re from 188W using polymer embedded nanocrystalline titania (TiP). Chromatographia 2009, 69:1363-1371.
20. Chakravarty R., Shukla R., Tyagi A.K., Dash A., Venkatesh M. Nanocrystalline zirconia: a novel sorbent for the preparation of 188W/188Re generator. Appl Radiat Isot 2010, 68:229-238.
21. Yin S.F., Xu B.Q. On the preparation of high surface area nano-zirconia by reflux digestion of hydrous zirconia gel in basic solution. Chemphyschem 2003, 3:277-281.
22. Gabriel M., Decristoforo C., Kendler D., Dobrozemsky G., Heute D., Uprimny C. 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 2007, 48:508-518.
23. Kowalski J., Henze M., Schuhmacher J., Macke H.R., Hoffmann M., Haberkom U. Evaluation of positron emission tomography imaging using [68Ga]-DOTA-d-Phe1-Tyr3-octreotide in comparison to [111In]-DTPA-OC SPECT. First results in patients with neuroendocrine tumours. Mol Imaging Biol 2003, 5:42-48.
24. Fengqiu T., Xiaoxian H., Yufeng Z., Jingkun G. Effect of dispersants on surface chemical properties of nano-zirconia suspensions. Ceram Int 2000, 26:93-97.
25. Neirinckx A.D., Davis M.A. Potential column chromatography generators for ionic Ga-68: I. Inorganic substrates. J Nucl Med 1979, 20:1075-1079.
26. Everest D.A., Salmon J.E. Studies in the chemistry of quadrivalent germanium: ion-exchange studies of solutions of germinates. J Chem Soc 1954, 2438-2443.
27. Bernstein L.R. Mechanisms of therapeutic activity for gallium. Pharmacol Rev 1998, 50:665-682.
28. Green M.A., Welch M.J. Gallium radiopharmaceutical chemistry. Int J Rad Appl Instrum B 1989, 16:435-448.
29. Bai X.M., Voter A.F., Hoagland R.G., Nastasi M., Uberuaga B.P. Efficient annealing of radiation damage near grain boundaries via interstitial emission. Science 2010, 327:1631-1634.