Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration

Nature

Volumn 472, Issue 7343, 2011, Pages 356-360

  Sentürk, Aycan ^a   Pfennig, Sylvia ^a   Weiss, Alexander ^a,b   Burk, Katja ^a,c   Acker Palmer, Amparo ^a  

^a GOETHE UNIVERSITY   (Germany)

^b MOUNT SINAI HOSPITAL   (Canada)

^c AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B1; EPHRIN B2; EPHRIN B3; REELIN;

BRAIN; MOLECULAR ANALYSIS; NERVOUS SYSTEM DISORDER; NEUROLOGY; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL MIGRATION; CEREBELLUM; CONTROLLED STUDY; DEVELOPMENT; FEMALE; GENE INTERACTION; GENE SILENCING; HIPPOCAMPUS; MOUSE; NEOCORTEX; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION MOLECULES, NEURONAL; CELL MOVEMENT; CEREBRAL CORTEX; EPHRIN-B1; EPHRIN-B2; EPHRIN-B3; EPHRINS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; LDL-RECEPTOR RELATED PROTEINS; LIGANDS; MALE; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; PHENOTYPE; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 79955467998     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09874     Document Type: Article

References (35)

1. D'Arcangelo, G. et al. Reelin is a ligand for lipoprotein receptors. Neuron 24, 471-479(1999). (Pubitemid 29508420)
2. Hong, S. E. et al. Autosomal recessive lissencephalywith cerebellar hypoplasia is associated with human RELN mutations. Nature Genet. 26, 93-96 (2000).
3. Herz, J. & Chen, Y. Reelin, lipoprotein receptorsandsynapticplasticity.Nature Rev. Neurosci. 7, 850-859 (2006).
4. Rakic, P.Specification ofcerebral cortical areas.Science241, 170-176(1988).
5. Bystron, I., Blakemore, C. & Rakic, P. Developmentof the human cerebral cortex: Boulder Committee revisited. Nature Rev. Neurosci. 9, 110-122 (2008).
6. Walsh, C A. & Goffinet, A. M. Potential mechanismsof mutations thataffect neuronal migration in man and mouse. Curr. Opin. Genet Dev. 10, 270-274 (2000). (Pubitemid 30307244)
7. Tissir, F. & Goffinet, A. M. Reelin and brain development. Nature Rev. Neurosci. 4, 496-505 (2003). (Pubitemid 37280170)
8. Howell, B. W., Herrick, T. M. & Cooper, J. A. Reelin-induced tyrosine phosphorylation of Disabled 1 during neuronal positioning. Genes Dev. 13, 643-648(1999). (Pubitemid 29155970)
9. Bock, H. H. & Herz, J. Reelin activates SRC familyt yrosinekinases in neurons. Curr. Biol. 13, 18-26 (2003). (Pubitemid 36080618)
10. Arnaud, L, Ballif, B. A., Forster, E. & Cooper, J. A. Fyn tyrosine kinase is a critica regulatorofdisabled-1 during brain development Curr. Biol. 13, 9-17 (2003). (Pubitemid 36080617)
11. Costa, E. et al. REELIN and schizophrenia: adiseaseat the interface of the genome and the epigenome. Mol. Interv. 2, 47-57 (2002).
12. Botella-Lopez, A. et al. Reelinexpression andglycosylation patternsarealtered in Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 5573-5578 (2006).
13. Sawamiphak, S. et al. Ephrin-B2 regulatesVEGFR2function indevelopmentaland tumourangiogenesis. Nature 465, 487-491 (2010).
14. Segura, I., Essmann, C. L, Weinges, S. & Acker-Palmer, A. Grb4 and GIT1 transduce ephrinB reversesignals modulatingspine morphogenesisandsynapseformation Nature Neurosci. 10, 301-310 (2007).
15. Essmann, C. L et al. Serine phosphorylation ofephrinB2 regulatestraffickingof synaptic AMPA receptors. Nature Neurosci. 11, 1035-1043 (2008).
16. Palmer, A. et al. EphrinB phosphorylation and reversesignaling: regulation bySrc kinases and PTP-BL phosphatase. Mol. Cell 9, 725-737 (2002). (Pubitemid 34454885)
17. Caviness, V. S. Jr & Rakic, P. Mechanismsofcortical development: a viewfrom mutations in mice. Annu. Rev. Neurosci. 1, 297-326 (1978).
18. Caviness, V. S. Jr. Neocortical histogenesis in normal and reelermice: a developmental study based upon [H]thymidineauto radiography. Brain Res. 256, 293-302 (1982). (Pubitemid 12052789)
19. Hevner, R.F. et al. Tbr1 regulates differentiation of the preplate and layer6. Neuron 29, 353-366 (2001). (Pubitemid 32206476)
20. Britanova, O. et al. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57, 378-392 (2008). (Pubitemid 351179166)
21. Sheppard, A. M. & Pearlman, A. LAbnormal reorganization of preplate neurons and their associated extracellular matrix: an early manifestation of altered neocortical development in the reeler mutant mouse.J. Comp. Neurol. 378, 173-179 (1997). (Pubitemid 27057519)
22. 1 integrinsa rerequired for the formation of the radial glial scaffold in the hippocampus. Proc. NatlAcad. Sci. USA 99, 13178-13183 (2002).
23. Liebl, D. J., Morris, C. J., Henkemeyer, M. & Parada, L F. mRNAexpression of ephrins andEph receptortyrosine kinases in the neonatal and adult mousecentral nervous system. J. Neurosci. Res. 71, 7-22 (2003). (Pubitemid 36008398)
24. Angrand, P. O. et al. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol. Cell. Proteomics 5, 2211-2227 (2006).
25. Trommsdorff, M. et al. Reeler/Disabled-likedisruption of neuronal migration in knockoutmice lackingtheVLDL receptorandApoE receptor2. Cell97, 689-701 (1999).
26. Lu, Q., Sun, E. E., Klein, R.S. & Flanagan, J. G. Ephrin-B reversesignaling is mediated bya novel PDZ-RGS protein andselectively inhibits G protein-coupled chemoattraction. Cell 105, 69-79 (2001). (Pubitemid 32323917)
27. Hack, I. et al. Divergent rolesof ApoER2 and Vldlr in the migration ofcortical neurons. Development 134, 3883-3891 (2007). (Pubitemid 350187347)
28. Alifragis, P., Parnavelas, J. G. & Nadarajah, B. A novel method of labeling and characterizing migrating neurons in the developing central nervous system. Exp. Neurol. 174, 259-265 (2002). (Pubitemid 34293454)
29. Ghoumari, A. M., Wehrle, R., Bernard, O., Sotelo, C. & Dusart, I. Implication of Bcl-2 andCaspase-3 in age-related Purkinjecelldeath in murineorganotypicculture: an in vitro model to study apoptosis. Eur. J. Neurosci. 12, 2935-2949 (2000).
30. Nadarajah, B., Brunstrom, J. E., Grutzendler, J., Wong, R. O. & Pearlman, A. L Two modes of radial migration in early development of the cerebral cortex. Nature Neurosci. 4, 143-150 (2001). (Pubitemid 32125258)
31. Kullander, K. et al. Ephrin-B3is them idlinebarrier that prevent scorticospinal tract axonsfrom recrossing, allowingforunilateral motorcontrol. Genes Dev. 15, 877-888 (2001).
32. Trommsdorff, M. et al. Reeler/Disabled-likedisruption of neuronal migration in knockout mice lackingtheVLDL receptor and ApoE receptor2. Cell97, 689-701 (1999). (Pubitemid 29278044)
33. Grunwald, I. C. et al. Hippocampal plasticity requires postsynaptic ephrinBs. Nature Neurosci. 7, 33-40 (2003).
34. Compagni, A., Logan, M., Klein, R. & Adams, R. H. Control ofskeletal patterningby ephrinB1-EphB interactions. Dev. Cell 5, 217-230 (2003). (Pubitemid 37006467)
35. Zhang, Y. & Bhavnani, B. R. Glutamate-induced apoptosis in primary cortica neurons is inhibited byequineestrogensvia down-regulation ofcaspase-3 and prevention of mitochondrial cytochromec release.BMCNeurosci.6, 13(2005).