Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groups

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2611-2615

  Wu, Chunrui ^a   Miller, Patricia A ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Amamistatins; Anti cancer; Design; Iron binding natural products; Structure activity relationships (SAR); Studies; Syntheses

Indexed keywords

AMAMISTATIN B DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; CATECHOL; ESTER; METAL CHELATE; OXAZOLE; OXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CONFERENCE PAPER; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IRON BINDING CAPACITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTINEOPLASTIC AGENTS; CATECHOLS; CELL LINE, TUMOR; CELL PROLIFERATION; CHELATING AGENTS; ESTERS; FEMALE; HUMANS; IRON; METALS; OLIGOPEPTIDES; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955463500     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.084     Document Type: Conference Paper

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