A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: Amodiaquine and sulphadoxine- pyrimethamine

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Mishra, Shrawan Kumar ^a   Singh, Prabhat ^a   Rath, Srikanta Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMODIAQUINE; ASPARTATE AMINOTRANSFERASE; CATALASE; DEAD BOX PROTEIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; PYRIMETHAMINE PLUS SULFADOXINE; SUPEROXIDE DISMUTASE; ANTIMALARIAL AGENT; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; LIVER; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CYTOCHEMISTRY; DRUG COMBINATION; DRUG EFFECT; GENE EXPRESSION PROFILING; METHODOLOGY; MICROARRAY ANALYSIS; PATHOLOGY;

AMODIAQUINE; ANIMALS; ANTIMALARIALS; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; GENE EXPRESSION PROFILING; HISTOCYTOCHEMISTRY; LIVER; MALE; MICE; MICROARRAY ANALYSIS; OXIDATIVE STRESS; PYRIMETHAMINE; SULFADOXINE;

EID: 79955459963     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-109     Document Type: Article

References (40)

1. The global distribution of clinical episodes of Plasmodium falciparum malaria. RW Snow CA Guerra AM Noor HY Myint SI Hay, Nature 2005 434 214 217 10.1038/nature03342 15759000 (Pubitemid 40388051)
2. A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. A Sowunmi, Ann Trop Med Parasitol 2002 96 227 238 10.1179/000349802125000763 12061970 (Pubitemid 34548044)
3. Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia. ER Lederman JD Maguire IW Sumawinata K Chand I Elyazar L Estiana P Sismadi MJ Bangs JK Baird, Malar J 2006 5 108 10.1186/1475-2875-5-108 17105658
4. World Health Organisation (WHO), Geneva. Malaria treatment guidelines, 2010
5. Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. DJ Bell SK Nyirongo M Mukaka EE Zijlstra CV Plowe ME Molyneux SA Ward PA Winstanley, PLoS One 2008 3 1578 10.1371/journal.pone.0001578 18270569
6. Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Cordoba, Colombia, 2006. MA Perez LJ Cortes AP Guerra A Knudson C Usta RS Nicholls, Biomedica 2008 28 148 159 18645670
7. Activities of artemether-lumefantrine and amodiaquine-sulfalene- pyrimethamine against sexual-stage parasites in falciparum malaria in children. A Sowunmi T Balogun GO Gbotosho CT Happi AA Adedeji OM Bolaji FA Fehintola OA Folarin, Chemotherapy 2008 54 201 208 10.1159/000140463 18560227 (Pubitemid 351929271)
8. The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. The East African Network for Monitoring Antimalarial Treatment (EANMAT), Trop Med Int Health 2003 10 860 867
9. Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children. AO Talisuna A Nalunkuma-Kazibwe N Bakyaita P Langi TK Mutabingwa WW Watkins E Van Marck U D'Alessandro TG Egwang, Trop Med Int Health 2004 9 222 229 10.1046/j.1365-3156.2003.01187.x 15040559 (Pubitemid 38250809)
10. Discussion Paper for the RBM PARTNERS' MEETING. WHO, Geneva, Salle B, 2002 26 28 http://www.emro.who.int/rbm/Publications/DiscussionPaper02.pdf
11. Antimalarial drug resistance. NJ White, J Clin Invest 2004 113 1084 1092 15085184 (Pubitemid 38544090)
12. Letter: Quinidine hepatotoxicity. JR Dzur, JAMA 1976 235 908 946113
13. Quinine-induced hepatotoxicity. DK Farver MN Lavin, Ann Pharmacother 1999 33 32 34 10.1345/aph.18172 9972382 (Pubitemid 29056555)
14. Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats. L Pari P Murugavel, J Appl Toxicol 2004 24 21 26 10.1002/jat.940 14745843 (Pubitemid 38181539)
15. Antimalarial drug toxicity. RJ Taylor NJ White, Drug Safety 2004 27 25 61 14720085
16. Drug-induced hepatotoxicity. WM Lee, N Engl J Med 2003 349 474 485 10.1056/NEJMra021844 12890847 (Pubitemid 36910027)
17. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats. K Minami T Saito M Narahara H Tomita H Kato H Sugiyama M Katoh M Nakajima T Yokoi, Toxicol Sci 2005 87 296 305 10.1093/toxsci/kfi235 15976192 (Pubitemid 41222682)
18. Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. S Noel S Sharma R Shanker SK Rath, Toxicology 2007 239 96 107 10.1016/j.tox.2007.06.098 17686563 (Pubitemid 47284616)
19. Identification of differentially expressed genes after acute exposure to bulaquine (CDRI 80/53) in mice liver. S Noel S Sharma R Shankar SK Rath, Basic Clin Pharmacol Toxicol 2008 103 522 529 10.1111/j.1742-7843.2008.00279.x 18684221
20. Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development. EA Blomme Y Yang JF Waring, Toxicol Lett 2009 186 22 31 10.1016/j.toxlet.2008.09.017 18996174
21. WHO Malaria Factsheet. http://www.who.int/mediacentre/factsheets/fs094/en
22. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. EJ Freireich EA Gehan DP Rall LH Schmidt HE Skipper, Cancer Chemother Rep 1966 50 219 244 4957125
23. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa N Ohishi K Yagi, Anal Biochem 1979 95 351 358 10.1016/0003-2697(79)90738-3 36810 (Pubitemid 9194347)
24. Tissue sulfhydryl groups. GL ELLMAN, Arch Biochem Biophys 1959 82 70 77 10.1016/0003-9861(59)90090-6 13650640
25. A modified spectrophotometric assay of superoxide dismutase. P Kakkar B Das PN Viswanathan, Indian J Biochem Biophys 1984 21 130 132 6490072 (Pubitemid 15207169)
26. Colorimetric assay of catalase. AK Sinha, Anal Biochem 1972 47 389 394 10.1016/0003-2697(72)90132-7 4556490
27. Glutathione peroxidase. A Wendel, Enzymatic Basis of Detoxication Academic Press, New York, Jakoby WB, 1980 333 348
28. Website describing the distribution of probes in microarray slides used in the experiments. http://www.microarrays.ca
29. TM4: a free, open-source system for microarray data management and analysis. AI Saeed V Sharov J White J Li W Liang N Bhagabati, Biotechniques 2003 34 374 378 12613259 (Pubitemid 36184095)
30. Gene Expression Omnibus Database. http://www.ncbi.nlm.nih.gov/geo/query/ acc.cgi?token=vjopbqokouiiqny&acc=GSE17392
31. Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction. V Luu-The N Paquet E Calvo J Cumps, Biotechniques 2005 38 287 293 10.2144/05382RR05 15727135 (Pubitemid 40216386)
32. A new mathematical model for relative quantification in real-time RT-PCR. MW Pfaffl, Nucleic Acids Res 2001 29 45 10.1093/nar/29.9.e45 11328886
33. Post-analysis follow-up and validation of microarray experiments. RF Chuaqui RF Bonner CJ Best JW Gillespie MJ Flaig SM Hewitt JL Phillips DB Krizman MA Tangrea M Ahram WM Linehan V Knezevic MR Emmert-Buck, Nat Genet 2002 32 Suppl 509 514 12454646 (Pubitemid 35435154)
34. GenMAPP-Pathway analysis tool. http://www.genmapp.org
35. A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase. C Cerini P Kerjan M Astier D Gratecos M Mirande M Semeriva, EMBO J 1991 10 4267 4277 1756734 (Pubitemid 21905459)
36. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. P Sampath B Mazumder V Seshadri CA Gerber L Chavatte M Kinter SM Ting JD Dignam S Kim DM Driscoll PL Fox, Cell 2004 119 195 208 10.1016/j.cell.2004.09.030 15479637 (Pubitemid 39360902)
37. Deficiency of ceruloplasmin in patients with hepatolenticular degeneration (Wilson's disease). IH Scheinberg D Gitlin, Science 1952 116 484 485 10.1126/science.116.3018.484 12994898
38. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. RW Johnstone RH See SF Sells J Wang S Muthukkumar C Englert DA Haber JD Licht SP Sugrue T Roberts VM Rangnekar Y Shi, Mol Cell Biol 1996 16 6945 6956 8943350 (Pubitemid 26389754)
39. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. JD Woronicz X Gao Z Cao M Rothe DV Goeddel, Science 1997 278 866 869 10.1126/science.278.5339.866 9346485 (Pubitemid 27467924)
40. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. P Berger S Bonneick S Willi M Wymann U Suter, Hum Mol Genet 2002 11 1569 1579 10.1093/hmg/11.13.1569 12045210 (Pubitemid 34679257)