Genetic control of susceptibility to infection with Candida albicans in mice

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Radovanovic, Irena ^a   Mullick, Alaka ^b   Gros, Philippe ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5; GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CANDIDA ALBICANS RESISTANCE GENE 3; CANDIDA ALBICANS RESISTANCE GENE 4; CANDIDIASIS; CHROMOSOME 11; CHROMOSOME 8; CODOMINANCE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC REGULATION; HAPLOTYPE MAP; INFECTION SENSITIVITY; MALE; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PHYLOGENY; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; ANIMAL; CHROMOSOME MAP; GENETIC PREDISPOSITION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAPLOTYPE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOUSE STRAIN; PHENOTYPE;

CANDIDA ALBICANS; MUS;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CHROMOSOME MAPPING; COMPLEMENT C5; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; LOD SCORE; MICE; MICE, INBRED STRAINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79955450697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018957     Document Type: Article

References (71)

1. Mathews HLW-JL, (2002) Host defense against oral, esophageal, and gastrointestinal candidiasis. CR, ed. Candida and candidiasis Washington, DC. ASM Press pp. 179-192.
2. Spellberg BJ, Filler SG, Edwards JE Jr, (2006) Current treatment strategies for disseminated candidiasis. Clin Infect Dis 42: 244-251.
3. Pappas PG, Rex JH, Lee J, Hamill RJ, Larsen RA, et al. (2003) A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis 37: 634-643.
4. Morgan J, (2005) Global trends in candidemia: review of reports from 1995-2005. Curr Infect Dis Rep 7: 429-439.
5. Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, et al. (2003) Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis 37: 1172-1177.
6. Pfaller MA, Diekema DJ, (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20: 133-163.
7. Shepherd MG, Poulter RT, Sullivan PA, (1985) Candida albicans: biology, genetics, and pathogenicity. Annu Rev Microbiol 39: 579-614.
8. Hector RF, Domer JE, Carrow EW, (1982) Immune responses to Candida albicans in genetically distinct mice. Infect Immun 38: 1020-1028.
9. Ashman RB, Bolitho EM, Papadimitriou JM, (1993) Patterns of resistance to Candida albicans in inbred mouse strains. Immunol Cell Biol 71 (Pt 3): 221-225.
10. Lanza F, (1998) Clinical manifestation of myeloperoxidase deficiency. J Mol Med 76: 676-681.
11. Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, et al. (2009) Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 361: 1760-1767.
12. Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, et al. (2010) Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. The Journal of experimental medicine 207: 291-297.
13. Glocker EO, Hennigs A, Nabavi M, Schaffer AA, Woellner C, et al. (2009) A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 361: 1727-1735.
14. Ashman RB, (2008) Protective and pathologic immune responses against Candida albicans infection. Front Biosci 13: 3334-3351.
15. Ashman RB, Fulurija A, Papadimitriou JM, (1996) Strain-dependent differences in host response to Candida albicans infection in mice are related to organ susceptibility and infectious load. Infect Immun 64: 1866-1869.
16. Ashman RB, Papadimitriou JM, Fulurija A, Drysdale KE, Farah CS, et al. (2003) Role of complement C5 and T lymphocytes in pathogenesis of disseminated and mucosal candidiasis in susceptible DBA/2 mice. Microb Pathog 34: 103-113.
17. Tuite A, Elias M, Picard S, Mullick A, Gros P, (2005) Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice. Genes Immun 6: 672-682.
18. Rhodes JC, Wicker LS, Urba WJ, (1980) Genetic control of susceptibility to Cryptococcus neoformans in mice. Infect Immun 29: 494-499.
19. Brummer E, Stevens DA, (1994) Anticryptococcal activity of macrophages: role of mouse strain, C5, contact, phagocytosis, and L-arginine. Cell Immunol 157: 1-10.
20. Mullick A, Elias M, Picard S, Bourget L, Jovcevski O, et al. (2004) Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun 72: 5868-5876.
21. Mullick A, Leon Z, Min-Oo G, Berghout J, Lo R, et al. (2006) Cardiac failure in C5-deficient A/J mice after Candida albicans infection. Infect Immun 74: 4439-4451.
22. Tuite A, Mullick A, Gros P, (2004) Genetic analysis of innate immunity in resistance to Candida albicans. Genes Immun 5: 576-587.
23. Lambris JD, Ricklin D, Geisbrecht BV, (2008) Complement evasion by human pathogens. Nat Rev Microbiol 6: 132-142.
24. Zipfel PF, (2009) Complement and immune defense: from innate immunity to human diseases. Immunol Lett 126: 1-7.
25. Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, et al. (2009) Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun 77: 3679-3685.
26. Ashman RB, (1998) A gene (Carg1) that regulates tissue resistance to Candida albicans maps to chromosome 14 of the mouse. Microb Pathog 25: 333-335.
27. Ashman RB, Fulurija A, Papadimitriou JM, (1998) A second Candida albicans resistance gene (Carg2) regulates tissue damage, but not fungal clearance, in sub-lethal murine systemic infection. Microb Pathog 25: 349-352.
28. Wetsel RA, Fleischer DT, Haviland DL, (1990) Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5′-exon. J Biol Chem 265: 2435-2440.
29. Kang HM, Zaitlen NA, Wade CM, Kirby A, Heckerman D, et al. (2008) Efficient control of population structure in model organism association mapping. Genetics 178: 1709-1723.
30. Cheverud JM, (2001) A simple correction for multiple comparisons in interval mapping genome scans. Heredity 87: 52-58.
31. Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, et al. (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448: 1050-1053.
32. MacCallum DM, Castillo L, Brown AJ, Gow NA, Odds FC, (2009) Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS One 4: e6420.
33. Romani L, Puccetti P, Mencacci A, Cenci E, Spaccapelo R, et al. (1994) Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol 152: 3514-3521.
34. Vazquez-Torres A, Jones-Carson J, Wagner RD, Warner T, Balish E, (1999) Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect Immun 67: 670-674.
35. Balish E, Wagner RD, Vazquez-Torres A, Pierson C, Warner T, (1998) Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178: 478-487.
36. Ashman RB, Fulurija A, Papadimitriou JM, (1997) Evidence that two independent host genes influence the severity of tissue damage and susceptibility to acute pyelonephritis in murine systemic candidiasis. Microb Pathog 22: 187-192.
37. Kitsios GD, Tangri N, Castaldi PJ, Ioannidis JP, (2010) Laboratory mouse models for the human genome-wide associations. PLoS One 5: e13782.
38. Kirby A, Kang HM, Wade CM, Cotsapas C, Kostem E, et al. (2010) Fine mapping in 94 inbred mouse strains using a high-density haplotype resource. Genetics 185: 1081-1095.
39. Su WL, Sieberts SK, Kleinhanz RR, Lux K, Millstein J, et al. (2010) Assessing the prospects of genome-wide association studies performed in inbred mice. Mamm Genome 21: 143-152.
40. McClurg P, Pletcher MT, Wiltshire T, Su AI, (2006) Comparative analysis of haplotype association mapping algorithms. BMC Bioinformatics 7: 61.
41. Manenti G, Galvan A, Pettinicchio A, Trincucci G, Spada E, et al. (2009) Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci. PLoS Genet 5: e1000331.
42. Cenci E, Mencacci A, Del Sero G, d'Ostiani CF, Mosci P, et al. (1998) IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection. J Immunol 161: 3543-3550.
43. Kullberg BJ, van 't Wout JW, Hoogstraten C, van Furth R, (1993) Recombinant interferon-gamma enhances resistance to acute disseminated Candida albicans infection in mice. J Infect Dis 168: 436-443.
44. Djeu JY, Blanchard DK, Halkias D, Friedman H, (1986) Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol 137: 2980-2984.
45. Marodi L, Schreiber S, Anderson DC, MacDermott RP, Korchak HM, et al. (1993) Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors. J Clin Invest 91: 2596-2601.
46. Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, et al. (1981) Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med 71: 59-66.
47. Schroder K, Hertzog PJ, Ravasi T, Hume DA, (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189.
48. Brierley MM, Fish EN, (2005) Stats: multifaceted regulators of transcription. J Interferon Cytokine Res 25: 733-744.
49. Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, et al. (2007) Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods 4: 651-657.
50. Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, et al. (2010) Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 142: 613-624.
51. Duan B, Davis R, Sadat EL, Collins J, Sternweis PC, et al. (2010) Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol 185: 335-344.
52. Watson PA, Krupinski J, Kempinski AM, Frankenfield CD, (1994) Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem 269: 28893-28898.
53. Ernst PB, Garrison JC, Thompson LF, (2010) Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol 185: 1993-1998.
54. Hertz AL, Bender AT, Smith KC, Gilchrist M, Amieux PS, et al. (2009) Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A 106: 21978-21983.
55. Peters-Golden M, (2009) Putting on the brakes: cyclic AMP as a multipronged controller of macrophage function. Sci Signal 2: pe37.
56. Buhl AM, Avdi N, Worthen GS, Johnson GL, (1994) Mapping of the C5a receptor signal transduction network in human neutrophils. Proc Natl Acad Sci U S A 91: 9190-9194.
57. Choubey D, Panchanathan R, (2008) Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett 119: 32-41.
58. Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, et al. (2010) Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS Genet 6: e1001016.
59. Tan J, Qiao W, Wang J, Xu F, Li Y, et al. (2008) IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. J Virol 82: 4275-4283.
60. Bange FC, Vogel U, Flohr T, Kiekenbeck M, Denecke B, et al. (1994) IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. J Biol Chem 269: 1091-1098.
61. Zhang L, Tang Y, Tie Y, Tian C, Wang J, et al. (2007) The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Cell Signal 19: 932-944.
62. Wang X, Johansen LM, Tae HJ, Taparowsky EJ, (1996) IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. Biochem Biophys Res Commun 229: 316-322.
63. Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, et al. (2009) The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 460: 405-409.
64. Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32: 681-691.
65. Eyerich K, Foerster S, Rombold S, Seidl HP, Behrendt H, et al. (2008) Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. J Invest Dermatol 128: 2640-2645.
66. Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, et al. (2010) Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. The Journal of experimental medicine 207: 299-308.
67. Zeller R, (2001) Fixation, embedding, and sectioning of tissues, embryos, and single cells. 11 Current protocols in molecular biology/edited by Frederick M Ausubel,et al. Chapter 14: Unit 14.
68. Fortin A, Diez E, Rochefort D, Laroche L, Malo D, et al. (2001) Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics 74: 21-35.
69. Haley CS, Knott SA, (1992) A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324.
70. Lander ES, Botstein D, (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
71. Broman KW, Wu H, Sen S, Churchill GA, (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890.