Endogenous vascular endothelial growth factor and angiopoietin-2 expression in critical limb ischemia

International Angiology

Volumn 30, Issue 1, 2011, Pages 25-34

  Brandao D ^a,b   Costa, C ^b,c,d   Canedo, A ^a   Vaz, G ^a   Pignatelli, D ^b,e,f  

^a Vila Nova de Gaia/Espinho Hospital Center   (Portugal)

^b University of Porto   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d iSEX Association for the Advanced Study of Human Sexuality   (Portugal)

^e HOSPITAL DE SÃO JOÃO   (Portugal)

^f UNIVERSITY OF PORTO   (Portugal)

Author keywords

Angiopoietin 2; Diabetes mellitus; Peripheral vascular disease; Vascular endothelial growth factor A

Indexed keywords

ANGIOPOIETIN 2; VASCULOTROPIN;

ADULT; AGED; AMPUTATION; ANGIOGENESIS; ARTICLE; CRITICAL LIMB ISCHEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIMB ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MUSCLE BIOPSY; MUSCLE CELL; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PROTEIN EXPRESSION; SKIN BIOPSY;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; AMPUTATION; ANGIOPOIETIN-1; BIOPSY; CAPILLARIES; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LOWER EXTREMITY; MALE; MIDDLE AGED; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; PORTUGAL; SKIN; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955437650     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Norgren I, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG et al. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Eur J Vasc Endovasc Surg 2007;33:S1-75.
2. Management of Peripheral Arterial Disease. TransAtlantic Inter-Society Consensus (TASC) Working Group. J Vasc Surg 2000;31:S1-S296.
3. Barandon L, Leroux L, Dufourcq P, Plagnol P, Deville C, Duplaa C et al. Gene therapy for chronic peripheral arterial disease: what role for the vascular surgeon? Ann Vasc Surg 2004;18:758-65.
4. Baumgartner I, Pieczek A, Manor O, Blair R, Kearney M, Walsh K et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998;97:1114-23. (Pubitemid 28152883)
5. Emanueli C, Madeddu P. Changing the logic of therapeutic angiogenesis for ischemic disease. Trends Mol Med 2005;11:207-16. (Pubitemid 40692310)
6. Rajagopalan S, Mohler III ER, Lederman RJ, Mendelsohn FO, Saucedo JF, Goldman CK et al. Regional angiogenesis with Vascular Endotelial Growth Factor in peripheral arterial disease. Circulation 2003;108:1933-8.
7. Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB et al. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study):a randomized trial. Lancet 2002;359:2053-8.
8. Kusumanto YH, van Weel V, Mulder NH, Smit AJ, van den Dungen JJ, Hooymans JM et al. Treatment with intramuscular vascular endotelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia:a double-blind trial. Hum Gene Ther 2006;17:683-91. (Pubitemid 43970708)
9. Ferrara N. Vascular Endotelial Growth Factor:basic science and clinical progress. Endocr Rev 2004;25:581-611. (Pubitemid 39099316)
10. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997;277:55-60.
11. Jones PF. Not just angiogenesis - wider roles for angiopoietins. J Pathol 2003;201:515-27. (Pubitemid 38256400)
12. Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF Science 1999;284:1994-8.
13. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SW, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000;407:242-8.
14. Lobov IB, Brooks PC, Lang RA. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci USA 2002;99:11205-10. (Pubitemid 34920903)
15. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
16. Carmeliet P. Angiogenesis in health and disease. Nature Medicine 2003;9:653-60. (Pubitemid 36749213)
17. Takeshita S, Tsurumi Y, Couffinahl T, Asahara T, Bauters C, Symes J et al. Gene transfer of naked DNA encoding for three isoforms os Vascular Endotelial Growth Factor stimulates collateral development in vivo. Lab Invest 1996;75:487-501.
18. Palmer-Kazen U, Wariaro D, Luo F, Wahlberg E. Vascular endothelial cell growth factor and fibroblast growth factor 2 expression in patients with critical limb ischemia. J Vasc Surg 2004;39:621-8. (Pubitemid 38298634)
19. Tuomisto TT, Rissanen TT, Vajanto I, Korkeela A, Rutanen J, Ylä-Herttuala S. HIF-VEGF-VEGFR-2, TNF-α and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array. Atherosclerosis 2004;174:111-20.
20. Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M et al. Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. Am J Pathol 2002;160:1393-403. (Pubitemid 34411643)
21. Detmar M, Brown L F, Berse B, et al. Hypoxia regulates the expression of Vascular Endothelial Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatolol 1997;108:263-8. (Pubitemid 27116221)
22. Detmar M, Brown LF, Claffey KP, Jackman RW, Elicker BM, Dvorak HF et al. Overexpression of Vascular Permeability Factor/ Vascular Endotelial Growth Factor and its receptors in psoriasis. J Exp Med 1994;180:1141-6. (Pubitemid 24256627)
23. Kishimoto J, Ehama R, Ge Y, Kobayashi T, Nishiyama T, Detmar M et al. In vivo detection of human Vascular Endothelial Growth Factor promoter activity in transgenic mouse skin. Am J Pathol 2000;157:103-10.
24. Choksy S, Pockley AG, Wajeh YE, Chan P. VEGF and VEGF receptor expression in human chronic limb ischemia. Euro J Vasc Endovasc Surg 2004;28:660-9. (Pubitemid 39462661)
25. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992;72:369-417.
26. Cherwek DH, Hopkins MB, Thompson MJ, Annex BH, Taylor DA. Fiber type-specific differential expression of angiogenic factors in response to chronic hindlimb ischemia. Am J Physiol Heart Circ Physiol 2000;279:H932-8.
27. Kern DS, Semmler JG, Enoka RM. Long-term activity in upper- and lower-limb muscles of humans. J Appl Physiol 2001;91:2224-32. (Pubitemid 33015077)
28. Annex BH, Torgan CE, Lin P, Taylor DA, Thompson MA, Peters KG. Induction and maintenance of increased VEGF protein by chronic motor stimulation in skeletal muscle. Am J Physiol Heart Circ Physiol 1998;274:H860-7
29. th edition. Churchill Livingstone;2004. p 1531-44.
30. Mandriota SJ, Pepper MS. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 1998;83:852-9. (Pubitemid 28489082)
31. Mandriota SJ, Pyke C, Di Sanza C, Quinodoz P, Pittet B, Pepper MS. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol 2000;156:2077-9.
32. Cao Y, Hong A, Schulten H, Post MJ. Update on therapeutic neovascularization. Cardiovasc Res 2005;65:639-48.
33. Shyu KG, Chang H, Wang BW, Kuan P. Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischemia. Am J Med 2003;114:85-92. (Pubitemid 36183588)
34. Reiss Y, Droste J, Heil M, Tribulova S, Schmidt MHH, Schaper W et al Angiopoietin-2 Impairs Revascularization After Limb Ischemia. Circulation Research. 2007;101:88-96 (Pubitemid 47094627)
35. Fagrell B, Intaglietta M. Microcirculation:its significance in clinical and molecular medicine. J Intern Med 1997, 24:349-62. (Pubitemid 27244659)
36. Heil M, Eitenmüller I, Schmitz-Rixen T, Schaper W. Arteriogenesis versus angiogenesis:similarities and differences. J Cell Mol Med 2006;10:45-55.