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An example of sequence-specific formation of heteropseudo- [3]rotaxane in which two different crown-ethers were threaded with a directional (asymmetric) thread was reported by schalley
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Instead, examples have been reported in which two different wheels were threaded with a symmetrical thread and consequently no isomerism was displayed
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An example of sequence-specific formation of heteropseudo- [3]rotaxane in which two different crown-ethers were threaded with a directional (asymmetric) thread was reported by Schalley: Jiang, W.; Winkler, H. D. F.; Schalley, C. A. J. Am. Chem. Soc. 2008, 130, 13852. Instead, examples have been reported in which two different wheels were threaded with a symmetrical thread and consequently no isomerism was displayed:
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Orientational isomers of a cyclodextrin [3]rotaxane have been obtained by linking two cyclodextrin-pseudo[2]rotaxane units. Thus, all three possible diastereoisomers have been obtained in a statistical ratio. A single directional isomer of a cyclodextrin-based pseudo[3]rotaxane was obtained under kinetic control
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Orientational isomers of a cyclodextrin [3]rotaxane have been obtained by linking two cyclodextrin-pseudo[2]rotaxane units. Thus, all three possible diastereoisomers have been obtained in a statistical ratio: Cheetham, A. G.; Claridge, T. D. W.; Anderson, H. L. Org. Biomol. Chem. 2007, 5, 457. A single directional isomer of a cyclodextrin-based pseudo[3]rotaxane was obtained under kinetic control:
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For the first examples of calixarene-based molecular shuttles obtained by using the same approach
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For the first examples of calixarene-based molecular shuttles obtained by using the same approach, see: Pierro, T.; Gaeta, C.; Talotta, C.; Casapullo, A.; Neri, P. Submitted.
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See Supporting Information for further details. MacroModel-9.0/Maestro-4. 1 program: Mohamadi, F.; Richards, N. G.; Guida, W. C.; Liskamp, R.; Lipton, M.; Caufield, C.; Chang, G.; Hendrickson, T.; Still, W. C. J. Comput. Chem. 1990, 11, 440.
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