Correlation of meta 1 expression with culture stage, cell morphology and infectivity in Leishmania (Leishmania) amazonensis promastigotes

Memorias do Instituto Oswaldo Cruz

Volumn 106, Issue 2, 2011, Pages 190-193

  dos Santos, Marcos Gonzaga ^a   da Silva, Maria Fernanda Laranjeira ^a   Zampieri, Ricardo Andrade ^a   Lafraia, Rafaella Marino ^b   Floeter Winter, Lucile Maria ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Meta 1 expression; Metacyclic morphology; Phosphatidylserine exposure

Indexed keywords

HEXAPODA; LEISHMANIA AMAZONENSIS; MAMMALIA; PROTOZOA;

EID: 79955423676     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/s0074-02762011000200012     Document Type: Article

References (16)

1. Bates PA, Tetley L 1993. Leishmania mexicana: induction of meta-cyclogenesis by cultivation of promastigotes at acidic pH. Exp Parasitol 76: 412-423.
2. Berberich C, Marín M, Ramírez JR, Muskus C, Vélez ID 1998. The metacyclic stage-expressed meta 1 gene is conserved between Old and New World Leishmania species. Mem Inst Oswaldo Cruz 93: 819-821.
3. Beverley SM 2003. Protozomics: trypanosomatid parasite genetics comes of age. Nat Rev Genet 4: 11-19.
4. Coulson RM, Smith DF 1990. Isolation of genes showing increased or unique expression in the infective promastigotes of Leishmania major. Mol Biochem Parasitol 40: 63-75.
5. Cunningham AC 2002. Parasitic adaptive mechanisms in infection by Leishmania. Exp Mol Pathol 72: 132-141.
6. da Silva ER, Castilho TM, Pioker FC, Tomich de Paula Silva CH,Floeter-Winter LM 2002. Genomic organisation and transcription characterisation of the gene encoding Leishmania (Leishma-nia) amazonensis arginase and its protein structure prediction. Int J Parasitol 32: 727-737.
7. Descoteaux A, Turco SJ 1999. Glycoconjugates in Leishmania infec-tivity. Biochim Biophys Acta 1455: 341-352.
8. Franke ED, McGreevy PB, Katz SP, Sacks DL 1985. Growth cycle-dependent generation of complement-resistant Leishmania pro-mastigotes. J Immunol 134: 2713-2718.
9. Nourbakhsh F, Uliana SR, Smith DF 1996. Characterisation and expression of a stage-regulated gene of Leishmania major. Mol Bio-chem Parasitol 76: 201-213.
10. Rogers M, Kropf P, Choi BS, Dillon R, Podinovskaia M, Bates P, Mül-ler I 2009. Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host mac-rophages to promote parasite survival. PLoS Pathog 5: e1000555.
11. Sacks DL, Hieny S, Sher A 1985. Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J Immunol 135: 564-569.
12. Sacks DL, Perkins PV 1984. Identification of an infective stage of Leishmania promastigotes. Science 223: 1417-1419.
13. Uliana SR, Goyal N, Freymüller E, Smith DF 1999. Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene. Exp Parasitol 92: 183-191.
14. van Zandbergen G, Bollinger A, Wenzel A, Kamhawi S, Voll R, Klinger M, Müller A, Hölscher C, Herrmann M, Sacks D, Sol-bach W, Laskay T 2006. Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc Natl Acad Sci USA 103: 13837-13842.
15. Wanderley JL, Moreira ME, Benjamin A, Bonomo AC, Barcinski MA 2006. Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts. J Immunol 176: 1834-1839.
16. Wanderley JL, Pinto da Silva LH, Deolindo P, Soong L, Borges VM, Prates DB, de Souza AP, Barral A, Balanco JM, do Nascimento MT, Saraiva EM, Barcinski MA 2009. Cooperation between apoptotic and viable metacyclics enhances the pathogenesis of Leishmaniasis. PLoS One 4: e5733.