A novel respiratory model of infection with monkeypox virus in cynomolgus macaques

Journal of Virology

Volumn 85, Issue 10, 2011, Pages 4898-4909

  Goff, Arthur J ^a   Chapman, Jennifer ^a   Foster, Chad ^b   Wlazlowski, Carly ^a   Shamblin, Joshua ^a   Lin, Kenny ^a   Kreiselmeier, Norman ^c   Mucker, Eric ^a   Paragas, Jason ^d   Lawler, James ^d   Hensley, Lisa ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b US Army Medical Department Center & School   (United States)

^c TRIPLER ARMY MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRONCHOPNEUMONIA; CLINICAL FEATURE; DISEASE MODEL; ESOPHAGUS ULCER; FEVER; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CYSTITIS; LUNG EDEMA; LUNG HEMORRHAGE; LYMPHADENOPATHY; MACACA; MONKEYPOX VIRUS; MORTALITY; MOUTH ULCER; NONHUMAN; PERITONITIS; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RASH; RESPIRATORY TRACT INFECTION; STOMACH ULCER; TESTIS DISEASE; TESTIS HEMORRHAGE; VIRUS LOAD;

ANIMALS; DISEASE MODELS, ANIMAL; MACACA FASCICULARIS; MONKEYPOX; MONKEYPOX VIRUS; RESPIRATORY TRACT INFECTIONS;

ANIMALIA; MACACA; MONKEYPOX VIRUS; PRIMATES; VARIOLA; VARIOLA VIRUS;

EID: 79955414001     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02525-10     Document Type: Article

References (18)

1. Bras, G. 1952. The morbid anatomy of smallpox. Doc. Med. Geogr. Trop. 4:303-351.
2. Centers for Disease Control and Prevention. 2003. Update: multistate outbreak of monkeypox-Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb. Mortal. Wkly. Rep. 52:642-646.
3. Councilman, M., G. B. Magrath, and W. R. Brinckerhoff. 1904. The pathological anatomy and histology of variola. J. Med. Res. 11:12-135.
4. Federal Register. 2002. New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible, final rule. Fed. Regist. 67:37988-37998.
5. Fenner, F., W. R., R. Wittek, and K. R. Dumbell. 1989. The Orthopoxviruses. Academic Press, San Diego, CA.
6. Huggins, J., et al. 2009. Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimi-crob. Agents Chemother. 53:2620-2625.
7. Hutin, Y. J., et al. 2001. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg. Infect. Dis. 7:434-438.
8. Jahrling, P. B., et al. 2004. Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox. Proc. Natl. Acad. Sci. U. S. A. 101:15196-15200.
9. Jordan, R., et al. 2009. ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrob. Agents Chemother. 53:1817-1822.
10. Kulesh, D. A., et al. 2004. Smallpox and pan-orthopox virus detection by real-time 3'-minor groove binder TaqMan assays on the Roche LightCycler and the Cepheid Smart Cycler platforms. J. Clin. Microbiol. 42:601-609.
11. Lillie, R. 1930. Smallpox and vaccinia: the pathologic histology. Arch. Pathol. 10:241-291.
12. Martin, D. B. 2002. The cause of death in smallpox: an examination of the pathology record. Mil. Med. 167:546-551.
13. Meyer, H., et al. 2002. Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001. J. Clin. Microbiol. 40:2919-2921.
14. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
15. Prophet, E. B., B. Mills, J. B. Arrington, and L. H. Sobin. 1992. Laboratory methods for histotechnology. Armed Forces Institute of Pathology, Washington, DC.
16. Rimoin, A. W., et al. 2007. Endemic human monkeypox, Democratic Republic of Congo, 2001-2004. Emerg. Infect. Dis. 13:934-937.
17. Rimoin, A. W., et al. 2010. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc. Natl. Acad. Sci. U. S. A. 107:16262-16267.
18. Zaucha, G. M., P. B. Jahrling, T. W. Geisbert, J. R. Swearengen, and L. Hensley. 2001. The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis). Lab Invest. 81:1581-1600.