Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure

European Journal of Heart Failure

Volumn 13, Issue 5, 2011, Pages 475-481

  Wijeysundera, Harindra C ^a,b   Parmar, Gurpreet ^a   Rongen, Gerard A ^c   Floras, John S ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c NONE   (Netherlands)

Author keywords

Angiotensin receptor blocker; Candesartan; Sympathetic nervous system; Total body norepinephrine spillover

Indexed keywords

ADENOSINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN; NITROPRUSSIDE SODIUM; NORADRENALIN; PLACEBO;

ADULT; ARTERIAL PRESSURE; ARTICLE; BRACHIAL ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; FOREARM BLOOD FLOW; HEART EJECTION FRACTION; HEART FAILURE; HEART RATE; HUMAN; NERVE POTENTIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYMPATHETIC REFLEX; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADENOSINE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BRACHIAL ARTERY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HEART FAILURE; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; NOREPINEPHRINE; REFLEX; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; TETRAZOLES; VASODILATOR AGENTS;

EID: 79955410040     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfr005     Document Type: Article

References (24)

1. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD. Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 1995;26:1257-1263.
2. Floras JS. Sympathetic activation in human heart failure: diverse mechanisms, therapeutic opportunities. Acta Physiol Scand 2003;177:391-398. (Pubitemid 36337643)
3. Floras JS. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll Cardiol 2009;54:375-385.
4. Cox DA, Vita JA, Treasure CB, Fish RD, Selwyn AP, Ganz P. Reflex increase in blood pressure during the intracoronary administration of adenosine in man. J Clin Invest 1989;84:592-596. (Pubitemid 19196992)
5. Edlund A, Berglund B, Kaijser L, Patrono C, Sollevi A, van DD, Wennmalm A. Release of adenosine and prostacyclin from ischemic human hearts. Adv Prostaglandin Thromboxane Leukot Res 1983;11:365-370.
6. Gamboa A, Ertl AC, Costa F, Farley G, Manier ML, Hachey DL, Diedrich A, Biaggioni I. Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans. Circulation 2003;108:2631-2635. (Pubitemid 37466803)
7. Katholi RE, Hageman GR,WhitlowPL,WoodsWT.Hemodynamic and afferent renal nerve responses to intrarenal adenosine in the dog. Hypertension 1983;5:I149-I154.
8. Thames MD, Kinugawa T, Dibner-Dunlap ME. Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine. Circulation 1993;87:1698-1704. (Pubitemid 23133114)
9. Rongen GA, Brooks SC, Ando S, Abramson BL, Floras JS. Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine. J Clin Invest 1998;101:769-776. (Pubitemid 28096073)
10. Rongen GA, Lenders JW, Lambrou J, Willemsen JJ, Van Belle H, Thien T, Smits P. Presynaptic inhibition of norepinephrine release from sympathetic nerve endings by endogenous adenosine. Hypertension 1996;27:933-938. (Pubitemid 26113842)
11. Notarius CF, Atchison DJ, Floras JS. Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise. Am J Physiol Heart Circ Physiol 2001; 280:H969-H976.
12. Funaya H, Kitakaze M, Node K, Minamino T, Komamura K, Hori M. Plasma adenosine levels increase in patients with chronic heart failure. Circulation 1997;95: 1363-1365. (Pubitemid 27142790)
13. Rongen GA, Brooks SC, Ando S, Notarius CF, Floras JS. Caffeine abstinence augments the systolic blood pressure response to adenosine in humans. Am J Cardiol 1998;81:1382-1385. (Pubitemid 28268685)
14. Notarius CF, Atchison DJ, Rongen GA, Floras JS. Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol Heart Circ Physiol 2001;281:H1312-H1318.
15. Riksen NP, van Ginneken EE, van den Broek PH, Smits P, Rongen GA. In vivo evidence against a role for adenosine in the exercise pressor reflex in humans. J Appl Physiol 2005;99:522-527. (Pubitemid 41061144)
16. Rongen GA, Floras JS, Lenders JW, Thien T, Smits P. Cardiovascular pharmacology of purines. Clin Sci (Lond) 1997;92:13-24. (Pubitemid 27033006)
17. Roig E, Perez-Villa F, Morales M, Jimenez W, Orus J, Heras M, Sanz G. Clinical implications of increased plasma angiotensin II despite ACE inhibitor therapy in patients with congestive heart failure. Eur Heart J 2000;21:53-57. (Pubitemid 30042669)
18. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, Esler MD. Cardiac sympathetic nerve function in congestive heart failure. Circulation 1996;93:1667-1676. (Pubitemid 26131343)
19. Esler M, Jennings G, Korner P, Blombery P, Sacharias N, Leonard P. Measurement of total and organ-specific norepinephrine kinetics in humans. Am J Physiol 1984; 247:E21-E28. (Pubitemid 14096121)
20. Clemson B, Gaul L, Gubin SS, Campsey DM, McConville J, Nussberger J, Zelis R. Prejunctional angiotensin II receptors. Facilitation of norepinephrine release in the human forearm. J Clin Invest 1994;93:684-691.
21. McMurray JJ, Ostergren J, Swedberg K, Granger CB, Held P, Michelson EL, Olofsson B, Yusuf S, Pfeffer MA. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensinconverting- enzyme inhibitors: the CHARM-Added trial. Lancet 2003;362:767-771. (Pubitemid 37093916)
22. Despas F, Detis N, Dumonteil N, Labrunee M, Bellon B, Franchitto N, Galinier M, Senard JM, Pathak A. Excessive sympathetic activation in heart failure with chronic renal failure: role of chemoreflex activation. J Hypertens 2009;27:1849-1854.
23. Azevedo ER, Kubo T, Mak S, Al-Hesayen A, Schofield A, Allan R, Kelly S, Newton GE, Floras JS, Parker JD. Nonselective versus selective beta-adrenergic receptor blockade in congestive heart failure: differential effects on sympathetic activity. Circulation 2001;104:2194-2199. (Pubitemid 33043299)
24. Massie BM, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, Weatherley BD, Cleland JG, Givertz MM, Voors A, DeLucca P, Mansoor GA, Salerno CM, Bloomfield DM, Dittrich HC. Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. N Engl J Med 2010;363:1419-1428.