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Volumn 34, Issue 1, 2011, Pages 69-77

Multifactorial intervention in Type 2 diabetes: The promise of incretin-based therapies

Author keywords

Blood pressure; Cardiovascular; Diabetes; GLP 1; Lipids; Steatosis

Indexed keywords

C REACTIVE PROTEIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INCRETIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

EID: 79955397107     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/bf03346698     Document Type: Short Survey
Times cited : (20)

References (68)
  • 1
    • 35649020800 scopus 로고    scopus 로고
    • The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976-2004
    • Gregg EW, Cheng YJ, Narayan KM, Thompson TJ, Williamson DF. The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976-2004. Prev Med 2007, 45: 348-52.
    • (2007) Prev Med , vol.45 , pp. 348-352
    • Gregg, E.W.1    Cheng, Y.J.2    Narayan, K.M.3    Thompson, T.J.4    Williamson, D.F.5
  • 2
    • 0345482583 scopus 로고
    • National Institutes of Health: Diabetes in America, ed. 2. Washington, DC: National Institutes of Health
    • National Institutes of Health: Diabetes in America, ed. 2. Washington, DC: National Institutes of Health; 1995. NIH Publication No. 95-1468.
    • (1995) NIH Publication No. 95-1468
  • 3
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285: 2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 4
    • 65949124036 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • American Diabetes Association; European Association for Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009, 32: 193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 5
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • The UK Prospective Diabetes Study (UKPDS) Group
    • The UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352: 837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 6
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995, 28: 103-17.
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 9
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • VADT Investigators
    • Duckworth W, Abraira C, Moritz T, et al; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360: 129-39.
    • (2009) N Engl J Med , vol.360 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 10
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group
    • Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP,Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008, 358: 2545-59.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 11
    • 34247195559 scopus 로고    scopus 로고
    • Pharmacotherapy for the treatment of patients with type 2 diabetes mellitus: Rationale and specific agents
    • DOI 10.1038/sj.clpt.6100156, PII 6100156
    • Cefalu WT. Pharmacotherapy for the treatment of patients with type 2 diabetes mellitus: rationale and specific agents. Clin Pharmacol Ther 2007, 81: 636-49. (Pubitemid 46625117)
    • (2007) Clinical Pharmacology and Therapeutics , vol.81 , Issue.5 , pp. 636-649
    • Cefalu, W.T.1    Waldman, S.2    Ryder, S.3
  • 12
    • 48749089599 scopus 로고    scopus 로고
    • Emerging incretin based therapies for type 2 diabetes: Incretin mimetics and DPP-4 inhibitors
    • Stonehouse A, Okerson T, Kendall D, Maggs D. Emerging incretin based therapies for type 2 diabetes: incretin mimetics and DPP-4 inhibitors. Curr Diabetes Rev 2008, 4: 101-9.
    • (2008) Curr Diabetes Rev , vol.4 , pp. 101-109
    • Stonehouse, A.1    Okerson, T.2    Kendall, D.3    Maggs, D.4
  • 13
    • 67650604595 scopus 로고    scopus 로고
    • The role of the gut microbiota in energy metabolism and metabolic disease
    • Cani PD, Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 2009, 15, 1546-58.
    • (2009) Curr Pharm Des , vol.15 , pp. 1546-1558
    • Cani, P.D.1    Delzenne, N.M.2
  • 14
    • 0028817815 scopus 로고
    • UKPDS 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
    • UKPDS Group
    • UKPDS Group. UKPDS 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995, 44: 1249-58.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 15
    • 0035489475 scopus 로고    scopus 로고
    • Postchallenge hyperglycemia in a national sample of U.S. adults with type 2 diabetes
    • Erlinger TP, Brancati FL. Postchallenge hyperglycemia in a national sample of U.S. adults with type 2 diabetes. Diabetes Care 2001, 24: 1734-8. (Pubitemid 33716474)
    • (2001) Diabetes Care , vol.24 , Issue.10 , pp. 1734-1738
    • Erlinger, T.P.1    Brancati, F.L.2
  • 17
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-hke peptide 1
    • Holst JJ. The physiology of glucagon-hke peptide 1. Physiol Rev 2007, 87: 1409-39.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 18
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG, et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986, 63: 492-8. (Pubitemid 16035703)
    • (1986) Journal of Clinical Endocrinology and Metabolism , vol.63 , Issue.2 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 19
    • 0014811685 scopus 로고
    • Further purification of a polypeptide demonstrating enterogastrone activity
    • Brown JC, Mutt V, Pederson RA. Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol 1970, 209: 57-64.
    • (1970) J Physiol , vol.209 , pp. 57-64
    • Brown, J.C.1    Mutt, V.2    Pederson, R.A.3
  • 20
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995, 80: 952-7.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 21
    • 33751506355 scopus 로고    scopus 로고
    • The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects
    • Vilsbøll T, Agersø H, Lauritsen T, al. The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects. Regul Pept 2006, 137: 168-72.
    • (2006) Regul Pept , vol.137 , pp. 168-172
    • Vilsbøll, T.1    Agersø, H.2    Lauritsen, T.3
  • 22
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006, 3: 153-65.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 23
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Göke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995, 7: 2294-300.
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-2300
    • Göke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 24
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998, 101: 515-20. (Pubitemid 28084232)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 25
    • 0031465745 scopus 로고    scopus 로고
    • Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: Glucagon-like peptide-1 and insulin interactions
    • DOI 10.1677/jme.0.0190241
    • Wang Y, Kole HK, Montrose-Rafizadeh C, Perfetti R, Bernier M, Egan JM. Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions. J Mol Endocrinol 1997, 19: 241-8. (Pubitemid 28023159)
    • (1997) Journal of Molecular Endocrinology , vol.19 , Issue.3 , pp. 241-248
    • Wang, Y.1    Kole, H.K.2    Montrose-Rafizadeh, C.3    Perfetti, R.4    Bernier, M.5    Egan, J.M.6
  • 26
    • 0032714917 scopus 로고    scopus 로고
    • Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats
    • Barragan JM, Eng J, Rodriguez R, Blazquez E. Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats. Am J Physiol 1999, 277: 784-91.
    • (1999) Am J Physiol , vol.277 , pp. 784-791
    • Barragan, J.M.1    Eng, J.2    Rodriguez, R.3    Blazquez, E.4
  • 27
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • DOI 10.1161/CIRCULATIONAHA.107.739938, PII 0000301720080506000007
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117: 2340-50. (Pubitemid 351653542)
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.-S.4    Drucker, D.J.5    Husain, M.6
  • 28
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • DOI 10.2337/diabetes.54.1.146
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54: 146-51. (Pubitemid 40105106)
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 29
    • 71449111050 scopus 로고    scopus 로고
    • Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells
    • Carraro-Lacroix LR, Malnic G, Girardi AC. Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. Am J Physiol Renal Physiol 2009, 297: F1647-55.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Carraro-Lacroix, L.R.1    Malnic, G.2    Girardi, A.C.3
  • 30
    • 48449104756 scopus 로고    scopus 로고
    • Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
    • Ferdaoussi M, Abdelli S, Yang JY, et al. Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes 2008, 57: 1205-15.
    • (2008) Diabetes , vol.57 , pp. 1205-1215
    • Ferdaoussi, M.1    Abdelli, S.2    Yang, J.Y.3
  • 31
    • 77953148018 scopus 로고    scopus 로고
    • Exendin-4 prevents c-jun N-terminal protein kinase activation by tumor necrosis factor (TNF)-α and inhibits TNFα-induced apoptosis in insulin-secreting cells
    • Natalicchio A, De Stefano F, Orlando MR, et al. Exendin-4 prevents c-jun N-terminal protein kinase activation by tumor necrosis factor (TNF)-α and inhibits TNFα-induced apoptosis in insulin-secreting cells. Endocrinology 2010, 151: 2019-29.
    • (2010) Endocrinology , vol.151 , pp. 2019-2029
    • Natalicchio, A.1    De Stefano, F.2    Orlando, M.R.3
  • 32
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2
    • DOI 10.2337/diacare.28.5.1092
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005, 28: 1092-100. (Pubitemid 40616618)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 34
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • for the DURATION-1 Study Group
    • Drucker DJ, Buse JB, Taylor K, et al; for the DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008, 372: 1240-50.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 35
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • for the LEAD-3 (Mono) Study Group
    • Garber A, Henry R, Ratner R, et al; for the LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009, 373: 473-81.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 36
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
    • for the Sitagliptin Study 024 Group
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP; for the Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2007, 9: 194-205.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 37
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • for the Sitagliptin Study 019 Group
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P; for the Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2006, 28: 1556-68.
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 38
    • 65549123794 scopus 로고    scopus 로고
    • Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial
    • for the CV181-039 Investigators
    • Jadzinsky M, Pfützner A, Paz-Pacheco E, Xu Z, Allen E, Chen R, for the CV181-039 Investigators. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. Diabetes Obes Metab 2009, 11: 611-22.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 611-622
    • Jadzinsky, M.1    Pfützner, A.2    Paz-Pacheco, E.3    Xu, Z.4    Allen, E.5    Chen, R.6
  • 39
    • 68949212458 scopus 로고    scopus 로고
    • Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial
    • for the CV181-040 Investigators
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R; for the CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial. Int J Clin Pract 2009, 63: 1395-406.
    • (2009) Int J Clin Pract , vol.63 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 40
    • 33847687205 scopus 로고    scopus 로고
    • Vildagliptin in drug-naive patients with type 2 diabetes: A 24-week, double-blind, randomized, placebo-controlled, multiple-dose study
    • Dejager S, Razac S, Foley JE, Schweizer A. Vildagliptin in drug-naive patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res 2007, 39: 218-23.
    • (2007) Horm Metab Res , vol.39 , pp. 218-223
    • Dejager, S.1    Razac, S.2    Foley, J.E.3    Schweizer, A.4
  • 41
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: A randomized, placebo-controlled study
    • DOI 10.1111/j.1463-1326.2006.00684.x, Future Treatments: A Focus on Dipeptidyl Peptidase-IV Inhibitors
    • Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab 2007, 9: 166-74. (Pubitemid 46206560)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.2 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3    Rochotte, E.4    Dejager, S.5
  • 42
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004, 110: 955-61. (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 43
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagonlike peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004, 109: 962-5. (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 45
    • 58949084130 scopus 로고    scopus 로고
    • Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
    • Timmers L, Henriques JP, de Kleijn DP, et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol 2009, 53: 501-10.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 501-510
    • Timmers, L.1    Henriques, J.P.2    De Kleijn, D.P.3
  • 46
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1 R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf MH, Momen MA, Ban K, et al. GLP-1 R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009, 58: 975-83.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3
  • 47
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice
    • Sauvé M, Ban K, Momen MA, Zhou YQ, Henkelman RM, Husain M, Drucker DJ. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice. Diabetes 2010, 59: 1063-73.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauvé, M.1    Ban, K.2    Momen, M.A.3    Zhou, Y.Q.4    Henkelman, R.M.5    Husain, M.6    Drucker, D.J.7
  • 48
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read PA, Khan FZ, Heck PM, Hoole SP, Dutka DP. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging 2010, 3: 195-201.
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3    Hoole, S.P.4    Dutka, D.P.5
  • 49
    • 77958184434 scopus 로고    scopus 로고
    • Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition
    • Bunck MC, Diamant M, Eliasson B, et al. Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care 2010, 33: 1734-7.
    • (2010) Diabetes Care , vol.33 , pp. 1734-1737
    • Bunck, M.C.1    Diamant, M.2    Eliasson, B.3
  • 50
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes
    • Courrèges JP, Vilsbøll T, Zdravkovic M, et al. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes. Diabet Med 2008, 25: 1129-31.
    • (2008) Diabet Med , vol.25 , pp. 1129-1131
    • Courrèges, J.P.1    Vilsbøll, T.2    Zdravkovic, M.3
  • 51
    • 77952316298 scopus 로고    scopus 로고
    • Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients
    • Derosa G, Maffioli P, Salvadeo SA, et al. Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients. Metabolism 2010, 59: 887-95.
    • (2010) Metabolism , vol.59 , pp. 887-895
    • Derosa, G.1    Maffioli, P.2    Salvadeo, S.A.3
  • 52
    • 77955020170 scopus 로고    scopus 로고
    • Effects of one year treatment of vildagliptin added to pioglitazone or glimepiride in poorly controlled type 2 diabetic patients
    • Derosa G, Maffioli P, Ferrari I, et al. Effects of one year treatment of vildagliptin added to pioglitazone or glimepiride in poorly controlled type 2 diabetic patients. Horm Metab Res 2010, 42: 663-9.
    • (2010) Horm Metab Res , vol.42 , pp. 663-669
    • Derosa, G.1    Maffioli, P.2    Ferrari, I.3
  • 53
    • 0027495779 scopus 로고
    • GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery
    • Richter G, Feddersen O, Wagner U, et al. GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery. Am J Physiol 1993, 265: L374-81.
    • (1993) Am J Physiol , vol.265
    • Richter, G.1    Feddersen, O.2    Wagner, U.3
  • 55
    • 8544258807 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    • Nyström T, Gutniak MK, Zhang Q, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004, 287: E1209-15.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Nyström, T.1    Gutniak, M.K.2    Zhang, Q.3
  • 56
    • 36148932551 scopus 로고    scopus 로고
    • Beneficial effects of GLP-1 on endothelial function in humans: Dampening by glyburide but not by glimepiride
    • Basu A, Charkoudian N, Schrage W et al. Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride. Am J Physiol Endocrinol Metab 2007, 293: E1289-95.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Basu, A.1    Charkoudian, N.2    Schrage, W.3
  • 58
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto TJ, Milton DR, Ridge TD, et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008, 30: 1448-60.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 59
    • 73349102524 scopus 로고    scopus 로고
    • The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: An overview of the LEAD 1-5 studies
    • Blonde L, Russell-Jones D. The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies. Diabetes Obes Metab 2009, 11 (Suppl 3): 26-34.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 3 , pp. 26-34
    • Blonde, L.1    Russell-Jones, D.2
  • 61
    • 65549100498 scopus 로고    scopus 로고
    • Long-term treatment with exenatide improved postprandial glycaemic control and was associated with a shift from small to large HDL and LDL particles
    • abstract
    • Kapitza C, Nauck MA, Kim D, Trautmann M, Johns D, Festa A. Long-term treatment with exenatide improved postprandial glycaemic control and was associated with a shift from small to large HDL and LDL particles. Diabetologia 2006, 49 (Suppl 1): 140-1 (abstract).
    • (2006) Diabetologia , vol.49 , Issue.SUPPL. 1 , pp. 140-141
    • Kapitza, C.1    Nauck, M.A.2    Kim, D.3    Trautmann, M.4    Johns, D.5    Festa, A.6
  • 62
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • LEAD-4 Study Investigators
    • Zinman B, Gerich J, Buse JB, et al; LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009, 32: 1224-30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 63
    • 30944469157 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and metabolic syndrome: What we know and what we don't know
    • Akbar DH, Kawther AH. Non-alcoholic fatty liver disease and metabolic syndrome: what we know and what we don't know. Med Sci Monit 2006, 12: RA23-6.
    • (2006) Med Sci Monit , vol.12
    • Akbar, D.H.1    Kawther, A.H.2
  • 64
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • DOI 10.1002/hep.21006
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006, 43: 173-81. (Pubitemid 43733604)
    • (2006) Hepatology , vol.43 , Issue.1 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.4    Anania, F.A.5
  • 65
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta NA, Mells J, Dunham RM, et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010, 51: 1584-92.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3
  • 67
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle J, Nauck MA, Matthews DR, et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab 2009, 11: 1163-72.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1163-1172
    • Jendle, J.1    Nauck, M.A.2    Matthews, D.R.3
  • 68
    • 77956051448 scopus 로고    scopus 로고
    • Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet
    • Lond
    • Souza-Mello V, Gregório BM, Cardoso-de-Lemos FS, de Carvalho L, Aguila MB, Mandarim-de-Lacerda CA. Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet. Clin Sci (Lond) 2010, 119: 239-50.
    • (2010) Clin Sci , vol.119 , pp. 239-250
    • Souza-Mello, V.1    Gregório, B.M.2    Cardoso-De-Lemos, F.S.3    De Carvalho, L.4    Aguila, M.B.5    Mandarim-De-Lacerda, C.A.6


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