Family history of stroke is an independent risk factor for lacunar stroke subtype with asymptomatic lacunar infarcts at younger ages

Stroke

Volumn 42, Issue 5, 2011, Pages 1196-1200

  Knottnerus, Iris L H ^a,b,f   Gielen, Marij ^c,d   Lodder, Jan ^a,b   Rouhl, Rob P W ^a   Staals, Julie ^a   Vlietinck, Robert ^e   Van Oostenbrugge, Robert J ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f MEDISCH SPECTRUM TWENTE   (Netherlands)

Author keywords

epidemiology; family history; genetics; lacunar stroke; risk factors

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN INFARCTION; DISEASE CLASSIFICATION; FAMILY HISTORY; FEMALE; HUMAN; INTERVIEW; LACUNAR STROKE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUESTIONNAIRE; RISK FACTOR; STROKE;

AGE FACTORS; BRAIN INFARCTION; CASE-CONTROL STUDIES; FAMILY HEALTH; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PHENOTYPE; RISK FACTORS; STROKE;

EID: 79955393807     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.602383     Document Type: Article

References (28)

1. Bamford J, Sandercock P, Jones L, Warlow C. The natural history of lacunar infarction: the Oxfordshire community stroke project. Stroke. 1987;18:545-551. (Pubitemid 17080565)
2. Donnan GA, Norrving B, Bammer R, Bogousslavsky J. Classification of subcortical infarcts. In: Donnan GA, Norrving B, Bamford J, Bogousslavsky J, eds. Subcortical Stroke. New York: Oxford University Press Inc; 2002: 27-34.
3. Fisher CM. The arterial lesions underlying lacunes. Acta Neuropathol (Berl). 1968;12:1-15.
4. Boiten J, Lodder J, Kessels F. Two clinically distinct lacunar infarct entities? ahypothesis. Stroke. 1993;24:652-656. (Pubitemid 23134281)
5. de Jong G, Kessels F, Lodder J. Two types of lacunar infarcts: further arguments from a study on prognosis. Stroke. 2002;33:2072-2076. (Pubitemid 34840070)
6. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, Hartung HP. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20:637-642. (Pubitemid 30429021)
7. Wardlaw JM, Lewis SC, Keir SL, Dennis MS, Shenkin S. Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions. Stroke. 2006;37: 2633-2636. (Pubitemid 44454690)
8. Kiely DK, Wolf PA, Cupples LA, Beiser AS, Myers RH. Familial aggregation of stroke: the Framingham Study. Stroke. 1993;24: 1366-1371. (Pubitemid 23254641)
9. Liao D, Myers R, Hunt S, Shahar E, Paton C, Burke G, Province M, Heiss G. Familial history of stroke and stroke risk: the Family Heart Study. Stroke. 1997;28:1908-1912. (Pubitemid 27458994)
10. Flossmann E, Schulz UG, Rothwell PM. Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke. 2004;35:212-227. (Pubitemid 38057622)
11. Polychronopoulos P, Gioldasis G, Ellul J, Metallinos IC, Lekka NP, Paschalis C, Papapetropoulos T. Family history of stroke in stroke types and subtypes. J Neurol Sci. 2002;195:117-122. (Pubitemid 34202288)
12. Jood K, Ladenvall C, Rosengren A, Blomstrand C, Jern C. Family history in ischemic stroke before 70 years of age: the Sahlgrenska Academy study on ischemic stroke. Stroke. 2005;36:1383-1387. (Pubitemid 40967498)
13. Jerrard-Dunne P, Cloud G, Hassan A, Markus HS. Evaluating the genetic component of ischemic stroke subtypes: a family history study. Stroke. 2003;34:1364-1369. (Pubitemid 36693499)
14. Knottnerus IL, Govers-Riemslag JW, Hamulyak K, Rouhl RP, Staals J, Spronk HM, van Oerle R, van Raak EP, Lodder J, ten Cate H, van Oostenbrugge RJ. Endothelial activation in lacunar stroke subtypes. Stroke. 2010;41:1617-1622.
15. Staals J, van Oostenbrugge RJ, Knottnerus IL, Rouhl RP, Henskens LH, Lodder J. Brain microbleeds relate to higher ambulatory blood pressure levels in first-ever lacunar stroke patients. Stroke. 2009;40:3264-3268.
16. Rouhl RP, van Oostenbrugge RJ, Knottnerus IL, Staals JE, Lodder J. Virchow-Robin spaces relate to cerebral small vessel disease severity. J Neurol. 2008;255:692-696.
17. Lammie GA. Pathology of small vessel stroke. Br Med Bull. 2000;56: 296-306.
18. Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. 2003;34:806-812.
19. Hassan A, Lansbury A, Catto AJ, Guthrie A, Spencer J, Craven C, Grant PJ, Bamford JM. Angiotensin converting enzyme insertion/deletion ge-notype is associated with leukoaraiosis in lacunar syndromes. J Neurol Neurosurg Psychiatry. 2002;72:343-346.
20. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large-and small-artery disease but not other etiologic subtypes of ische-mic stroke. Stroke. 2000;31:1069-1075. (Pubitemid 30253527)
21. Jackson C, Sudlow C. Are lacunar strokes really different? a systematic review of differences in risk factor profiles between lacunar and non-lacunar infarcts. Stroke. 2005;36:891-901.
22. Schulz UG, Flossmann E, Rothwell PM. Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies. Stroke. 2004;35:819-824. (Pubitemid 38419784)
23. Flossmann E, Rothwell PM. Family history of stroke in patients with transient ischemic attack in relation to hypertension and other inter-mediate phenotypes. Stroke. 2005;36:830-835.
24. Lindgren A, Lovkvist H, Hallstrom B, Hoglund P, Jonsson AC, Kristof-fersson U, Luthman H, Petersen B, Norrving B. Prevalence of stroke and vascular risk factors among first-degree relatives of stroke patients and control subjects: a prospective consecutive study. Cerebrovasc Dis. 2005; 20:381-387. (Pubitemid 41551989)
25. Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, Wolf PA, Miller BL. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke. 1998;29:1177-1181. (Pubitemid 28265474)
26. Atwood LD, Wolf PA, Heard-Costa NL, Massaro JM, Beiser A, D'Agostino RB, DeCarli C. Genetic variation in white matter hyperin-tensity volume in the Framingham Study. Stroke. 2004;35:1609-1613. (Pubitemid 38823634)
27. Leistner S, Huebner N, Faulstich A, Ludwig D, Rees M, Marx P, Langer B, Nikolova A, Hartmann A, Koennecke HC. Increased prevalence of microangiopathic brain lesions among siblings of patients with lacunar stroke: a prospective multicenter study. Eur Neurol. 2008;59:143-147. (Pubitemid 351301257)
28. van Straaten EC, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D, Waldemar G, Erkinjuntti T, Mantyla R, Wahlund LO, Barkhof F. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS Study. Stroke. 2006;37:836-840. (Pubitemid 43731918)